A pediatric case of acute meningitis due to Streptococcus pneumoniae serotype 33D

Streptococcus pneumoniae is a leading cause of bacterial meningitis in children. It is also responsible for bacteremia, sepsis, pneumonia, sinusitis and acute otitis media in young children worldwide. The serotypes included in the 7-valent conjugated pneumococcal vaccine (PCV7)--1, 5, 6A, 6B, 14, 19F, 23F--are those most commonly responsible for invasive pneumococcal disease (IPD) globally. Unvaccinated children are at greater risk for meningitis. The rate of non-vaccine serotypes as causes of invasive disease has increased. Although the incidence rate of IPD is highest in children aged <2 years, the rare, non-vaccine serotypes of S. pneumoniae may be responsible for acute meningitis in older, unvaccinated children. In this report, we present a pediatric case of meningitis due to S. pneumoniae serotype 33D, which has not been previously identified as a cause of IPD in those countries where PCV7 is routinely administered, including Turkey.

___

1. Hamrick SE, Hansmann G. Patent ductus arteriosus of the preterm infant. Pediatrics 2010; 125: 1020-1030.

2. Echtler K, Stark K, Lorenz M, et al. Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med 2010; 16: 75-82.

3. Clyman R, Chemtob S. Vessel remodeling in the newborn: platelets fill the gap. Nat Med 2010; 16: 33-35.

4. Shah NA, Hills NK, Waleh N, et al. Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment. J Pediatr 2011; 158: 919-923.

5. Alyamac Dizdar E, Ozdemir R, Sari FN, et al. Low platelet count is associated with ductus arteriosus patency in preterm newborns. Early Hum Dev 2012; 88: 813-816.

6. Sallmon H, Weber SC, Hüning B, et al. Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus. Pediatrics 2012; 130: e623-e630.

7. Fujioka K, Morioka I, Miwa A, et al. Does thrombocytopenia contribute to patent ductus arteriosus? Nat Med 2011; 17: 29-30.

8. Dani C, Poggi C, Fontanelli G. Relationship between platelet count and volume and spontaneous and pharmacological closure of ductus arteriosus in preterm infants. Am J Perinatol 2013; 30: 359-364.

9. Antoniades HN. PDGF: A multifunctional growth factor. Baillieres Clin Endocrinol Metab 1991; 5: 595-613.

10. Bowen-Pope DF, Raines EW. History of discovery: platelet-derived growth factor. Arterioscler Thromb Vasc Biol 2011; 31: 2397-2401.

11. Hoch RV, Soriano P. Roles of PDGF in animal development. Development 2003; 130: 4769-4784.

12. Heldin CH, Ostman A, Rönnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta 1998; 1378: F79-F113.

13. Baumgartner HR, Hosang M. Platelets, platelet-derived growth factor and arteriosclerosis. Experientia 1988; 44: 109-112.

14. Li C, Li J, Li Y, et al. Crosstalk between platelets and the immune system: old systems with new discoveries. Adv Hematol 2012; 2012: 384685.

15. Coceani F, Baragatti B. Mechanisms for ductus arteriosus closure. Semin Perinatol 2012; 36: 92-97.

16. Bökenkamp R, DeRuiter MC, van Munsteren C, Gittenberger-de Groot AC. Insights into the pathogenesis and genetic background of patency of the ductus arteriosus. Neonatology 2010; 98: 6-17.

17. Clyman RI. Mechanisms regulating the ductus arteriosus. Biol Neonate 2006; 89: 330-335.

18. Engür MA, Engür D. Platelet-rich plasma for patent ductus arteriosus: an orthopaedic surgeon's perspective. Cardiol Young 2014; 24: 385-387.

19. Lin F, Zhu J, Tonnesen MG, et al. Fibronectin peptides that bind PDGF-BB enhance survival of cells and tissue under stress. J Invest Dermatol 2014; 134: 1119-1127.

20. Weber SC, Gratopp A, Akanbi S, et al. Isolation and culture of fibroblasts, vascular smooth muscle, and endothelial cells from the fetal rat ductus arteriosus. Pediatr Res 2011; 70: 236-241.

21. Seppä H, Grotendorst G, Seppä S, Schiffmann E, Martin GR. Platelet-derived growth factor in chemotactic for fibroblasts. J Cell Biol 1982; 92: 584-588.

22. Heldin P, Asplund T, Ytterberg D, Thelin S, Laurent TC. Characterization of the molecular mechanism involved in the activation of hyaluronan synthetase by platelet-derived growth factor in human mesothelial cells. Biochem J 1992; 283: 165-170.

23. McNamara PJ, Sehgal A. Towards rational management of the patent ductus arteriosus: the need for disease staging. Arch Dis Child Fetal Neonatal Ed 2007; 92: F424-F427.

13. Centers for Disease Control and Prevention. Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among children aged 6-18 years with immunocompromising conditions: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 2013; 62: 521-524.

14. Kaplan SL, Barson WJ, Lin PL, et al. Early trends for invasive pneumococcal infections in children after the introduction of the 13-valent pneumococcal conjugate vaccine. Pediatr Infect Dis J 2013; 32: 203-207
Turkish Journal of Pediatrics-Cover
  • ISSN: 0041-4301
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1958
  • Yayıncı: Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü
Sayıdaki Diğer Makaleler

Sapropterin dihydrochloride treatment in Turkish hyperphenylalaninemic patients under age four

Ali DURSUN, Hülya GÖKMEN-ÖZEL, Ayşegül TOKATLI, Özlem ÜNAL, Didem YÜCEL, Burcu HİŞMİ, R. Köksal ÖZGÜL, H Serap SİVRİ, Turgay COŞKUN

A giant hydatid cyst atypically located in the left ventricle

Recep Oktay PEKER, Timuçin SABUNCU, Ulaş KUMBASAR, MURAT GÜVENER, METİN DEMİRCİN, İlhan PAŞAOĞLU

An easily missed diagnosis: 17-alpha-hydroxylase/17,20-lyase deficiency

Feyza DARENDELİLER, Alev YILMAZ, Firdevs BAŞ, Şükran POYRAZOĞLU, Sevinç EMRE, Ilmay BİLGE, Nurçin SAKA, Banu KÜÇÜKEMRE-AYDIN, Özlem ÖĞRENDİL-YANAR, Rüveyde BUNDAK

A pediatric case of acute meningitis due to Streptococcus pneumoniae serotype 33D

Ayşe KAMAN, Türkan AYDIN-TEKE, Fatma Nur ÖZ, GÜLSÜM İCLAL BAYHAN, ÖZGE METİN AKCAN, ZEYNEP GÖKÇE GAYRETLİ AYDIN, Gönül TANIR

Intralobar pulmonary sequestration associated with congenital broncho-esophageal fistula

Erkan DİKMEN, Rıza DOĞAN, Sevgen ÖNDER

The prognostic role of prenatal MRI volumetric assessment in fetuses with isolated ventriculomegaly

Handan GÜLERYÜZ, Naciye Sinem GEZER, İbrahim Egemen ERTAŞ, Didem YEŞİLIRMAK, Atalay EKİN, Cenk GEZER, Ali KOÇYİĞİT, Muzaffer BİLGİN

Prevalence of and risk factors for otitis media with effusion in primary school children: case control study in Erzurum, Turkey

Cüneyt KUCUR, Ozan KUDUBAN, İsa ÖZBAY, Eda ŞİMŞEK

Conventional and advanced MR imaging in infantile Refsum disease

Göknur HALİLOĞLU, Kader KARLI-OĞUZ, Merall TOPÇU, Ronald James WANDERS, Mustafa KILIÇ, Turgay COŞKUN

Platelets and platelet-derived growth factor in closure of the ductus arteriosus

Defne ENGÜR, MÜNEVVER KAYNAK TÜRKMEN, MURAT DEVECİ, ÇİĞDEM YENİSEY

Blue-colored sweating: four infants with apocrine chromhidrosis

Neslihan ÖNENLİ-MUNGAN, Ahmet YÖNTEM, Mehmet KARAKAŞ, Bircan HIZLI-KARABACAK, Deniz KÖR