A case with atrophic autoimmune thyroiditis-related hypothyroidism causing multisystem involvement in early childhood

Kurnaz E, Savaş-Erdeve Ş, Keskin M, Doğan V, Çetinkaya S, Aycan Z. A case with atrophic autoimmune thyroiditis-related hypothyroidism causing multisystem involvement in early childhood. Turk J Pediatr 2016; 58: 446-451. The most common reason of acquired hypothyroidism is autoimmune (Hashimoto) thyroiditis. Autoimmune thyroiditis can be atrophic or goitrogenic. Atrophic autoimmune thyroiditis (ATT) related acquired hypothyroidism causes interruption of growth, obesity, and bone age retardation in early ages while goitrogenic thyroiditis has a higher incidence rate and mostly presents with diffuse goiter. We discuss the effects of hypothyroidism on various systems through a case found to have pericardial effusion during the echocardiography performed after cardiac murmur was detected and later diagnosed with ATT related hypothyroidism

___

1. LaFranchi SH. Thyroiditis. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, Behrman RE (eds). Nelson Textbook of Pediatrics (19th ed). Philadelphia: Elsevier Saunders; 2011: 1879-1881.

2. Matsuura N, Konishi J, Yuri K, et al. Comparison of atrophic and goitrous auto-immune thyroiditis in children: clinical, laboratory and TSH-receptor antibody studies. Eur J Pediatr 1990; 149: 529-533.

3. Tronconi GM, Caiulo S, Di Frenna M, et al. Rare cases of autoimmune hypothyroidism in young children. J Pediatr Endocrinol Metab 2013; 26: 963-966.

4. Powell BR, Buist NR, Stenzel P. An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy. J Pediatr 1982; 100: 731-737.

5. Savage MO, Mirakian R, Wozniak ER, et al. Specific autoantibodies to gut epithelium in two infants with severe protracted diarrhoea. J Pediatr Gastroenterol Nutr 1985; 4: 187-195.

6. Ostergaard GZ, Jacobsen BB. Atrophic, autoimmune thyroiditis in infancy. A case report. Horm Res 1989; 31: 190-192.

7. Kaino Y, Otoh Y, Tokuda K, et al. Acquired hypothyroidism in a very young infant with Omenn’s syndrome. J Pediatr 2000; 136: 111-113.

8. Joergensen JV, Oerbeck B, Jebsen P, et al. Severe hypothyroidism due to atrophic thyroiditis from second year of life influenced developmental outcome. Acta Paediatr 2005; 94: 1049-1054.

9. Foley TP Jr, Abbassi V, Copeland KC, Draznin MB. Brief report: hypothyroidism caused by chronic autoimmune thyroiditis in very young infants. N Engl J Med 1994; 330: 466-468.

10. Tronconi GM, Caiulo S, Di Frenna M, et al. Rare cases of autoimmune hypothyroidism in young children. J Pediatr Endocrinol Metab 2013; 26: 963-966.

11. Chandanwale SS, Gore CR, Bamanikar SA, et al. Cytomorphologic spectrum of Hashimoto’s thyroiditis and its clinical correlation: a retrospective study of 52 patients. Cytojournal 2014; 29; 11: 9.

12. Levy PY, Corey R, Berger P, et al. Etiologic diagnosis of 204 pericardial effusions. Medicine (Baltimore) 2003; 82: 385-391.

13. Mittnacht J, Schmidt F, Ebinger F, Bettendorf M. Unusual clinical presentation of primary hypothyroidism in a very young infant caused by autoimmune thyroiditis: case report and update of the literature. Eur J Pediatr 2007; 166: 881-883.

14. Sanda S, Newfield RS. A child with pericardial effusion and cardiac tamponade due to previously unrecognized hypothyroidism. J Natl Med Assoc 2007; 99: 1411- 1413.

15. Hayford JT, Schieken RM, Thompson RG. Cardiac function in primary hypothyroidism. Am J Dis Child 1980; 134: 556-559.

16. Dharaskar P, Tullu MS, Lahiri KR, et al. Case report. Kocher-Debre-Semelaigne syndrome with pericardial effusion. Indian J Med Sci 2007; 61: 527-530.

17. Tullu MS, Udgirkar VS, Muranjan MN, et al. KocherDebre- Semelaigne syndrome: hypothyroidism with muscle pseudohypertrophy. Indian J Pediatr 2003; 70: 671-673.

18. Tullu MS, Bavdekar SB. Kocher-Debre-Semelaigne syndrome. In: Gupta S, editor. Recent Advances in pediatrics, Special Volume on Pediatric Endocrinology. Jaypee Brothers: New Delhi; 2004: 159-162.

19. Sarlis NJ, Brucker-Davis F, Doppman JL, Skarulis MC. MRI-demonstrable regression of a pituitary mass in a case of primary hypothyroidism after a week of acute thyroid hormone therapy. J Clin Endocrinol Metab 1997; 82: 808-811.

20. Simşek E, Simşek T, Savaş-Erdeve S, et al. Pituitary hyperplasia mimicking pituitary macroadenoma in two adolescent patients with long-standing primary hypothyroidism: case reports and review of literature. Turk J Pediatr 2009; 51: 624-630.

21. Ishiguro M, Yamamoto H, Masuda M, et al. Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene. Biochem J 2010; 427: 161-169.
Turkish Journal of Pediatrics-Cover
  • ISSN: 0041-4301
  • Yayın Aralığı: 6
  • Başlangıç: 1958
  • Yayıncı: Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü
Sayıdaki Diğer Makaleler

Anti-cyclic citrullinated peptide antibodies are not frequently observed in children with type 1 diabetes mellitus: a single- center study

Melek YILDIZ, Özlem NALBANTOĞLU, Nilüfer ÇELİK, Figen İŞLETEN, Birsen TUĞLU, Behzat ÖZKAN, Korcan DEMİR, Hüseyin Anıl KORKMAZ

Pediatric langerhans cell histiocytosis: single center experience over a 17-year period

Serra KAMER, Selcen KUNDAK, Ragıp ORTAÇ, Yöntem YAMAN, Bengü DEMİRAĞ, Canan VERGİN, Yeşim OYMAK, Gülcihan ÖZEK, Dilek İNCE, Ayşe ERBAY

Clarithromycin resistance and 23S rRNA gene point mutations of Helicobacter pylori infection in children

YELİZ ÇAĞAN APPAK, Hörü GAZi, SEMİN AYHAN, BEYHAN CENGİZ ÖZYURT, Semra KURUTEPE, Erhun KASIRGA

The first childhood case with coexisting Hashimoto thyroiditis, vitiligo and autoimmune hepatitis

Şenay SAVAŞ-ERDEVE, Semra ÇETİNKAYA, Ferda ÖZBAY-HOŞNUT, Erdal KURNAZ, Melikşah KESKİN, Zehra AYCAN¹

Two newborn babies with generalized arterial calcification of infancy, two new mutations

Hacer YAPICIOĞLU YILDIZDAŞ, Nazan ÖZBARLAS, SEVCAN ERDEM, MEHMET BERTAN YILMAZ, Ferda ÖZLÜ, Selim BÜYÜKKURT, Süreyya SOYUPAK, Utku GÜLLÜ, KADRİ KARAER

Genotypic and phenotypic features of the cystinosis patients from the South Eastern part of Turkey

HALİSE NESLİHAN ÖNENLİ MUNGAN, BERNA ŞEKER YILMAZ, Ali Kemal TOPALOĞLU, Bilgin YÜKSEL, Ali ANARAT, Gülay CEYLANER, Aytül NOYAN, DENİZ KOR, Aysun KARABAY-BAYAZIT, NURCAN CENGİZ, Sevgi YAVUZ

Local hypertrichosis: A rare complication of a temporary henna tattoo

Nebahat Demet AKPOLAT, Arzu ARAS

Multisystem langerhans cell histiocytosis with thymic involvement diagnosed with anterior mediastinal mass in a 2-month-old boy

Funda TEKKEŞİN, Arzu OKUR, Betül Emine DERİNKUYU, Nalan AKYÜREK, Aynur OĞUZ, Ceyda KARADENİZ, FARUK GÜÇLÜ PINARLI

An unusual manifestation: Papillary thyroid carcinoma in a patient with ataxia-telengiectasia

GÜZİDE AKSU, ŞÜKRAN DARCAN, SAMİM ÖZEN, Damla GÖKŞEN, NESLİHAN KARACA, Ezgi ULUSOY, NECİL KÜTÜKÇÜLER, YEŞİM ERTAN

Oxygen therapy via high flow nasal cannula in pediatric intensive care unit

Arzu OTO, Seher ERDOĞAN, MEHMET BOŞNAK