Funda TEKKEŞİN, Arzu OKUR, Betül Emine DERİNKUYU, Nalan AKYÜREK, Aynur OĞUZ, Ceyda KARADENİZ, FARUK GÜÇLÜ PINARLI

Multisystem langerhans cell histiocytosis with thymic involvement diagnosed with anterior mediastinal mass in a 2-month-old boy

Tekkeşin F, Okur A, Derinkuyu BE, Akyürek N, Oğuz A, Karadeniz C, Pınarlı FG. Multisystem langerhans cell histiocytosis with thymic involvement diagnosed with anterior mediastinal mass in a 2 month-old boy. Turk J Pediatr 2016; 58: 424-428.Thymus gland involvement in Langerhans cell histiocytosis (LCH) is usually part of multi-system disease and may be more common than previously recognized. However, thymic involvement causing an anterior mediastinal mass is an extremely rare presentation of multisystem LCH. Here we report a 2-month-old-boy admitted to hospital with a giant anterior mediastinal mass with multisystem LCH involving the thymus, lungs, liver and skin. The differential diagnosis of mediastinal mass in children should also include LCH, especially multisystem disease. LCH should also be kept in mind in the differential diagnosis of skin lesions in infants, even if spontaneous regression occurs.

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