Utility of M30, an apoptotic serum marker, in liver diseases

The aim of this paper is to evaluate the role of apoptosis in some common liver diseases, and the utility of M30, an apoptotic serum marker, in the diagnosis of the severity of underlying hepatic injury. As is widely known, apoptosis is programmed cell death, and its deregulation results in an uncontrolled inflammatory process leading to upregulation of liver fibrogenesis. Both extrinsic and intrinsic pathways are crucial in apoptosis, and caspase cleavage of cytokeratin proteins occurs in both. Therefore, the measurement of caspase-cleaved cytokeratin fragments could be a novel method to assess the intensity of apoptotic cell numbers in epithelial tissue damage. M30 levels were found to increase not only in acute liver disorders, but also in some chronic liver injuries. We tried to summarize the recent studies focused on the role of apoptotic processes in liver diseases, mainly those that investigated the use of M30 in determining the severity of, or in predicting, ongoing liver injury.

Utility of M30, an apoptotic serum marker, in liver diseases

The aim of this paper is to evaluate the role of apoptosis in some common liver diseases, and the utility of M30, an apoptotic serum marker, in the diagnosis of the severity of underlying hepatic injury. As is widely known, apoptosis is programmed cell death, and its deregulation results in an uncontrolled inflammatory process leading to upregulation of liver fibrogenesis. Both extrinsic and intrinsic pathways are crucial in apoptosis, and caspase cleavage of cytokeratin proteins occurs in both. Therefore, the measurement of caspase-cleaved cytokeratin fragments could be a novel method to assess the intensity of apoptotic cell numbers in epithelial tissue damage. M30 levels were found to increase not only in acute liver disorders, but also in some chronic liver injuries. We tried to summarize the recent studies focused on the role of apoptotic processes in liver diseases, mainly those that investigated the use of M30 in determining the severity of, or in predicting, ongoing liver injury.

Kaynakça

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Kaynak Göster

Bibtex @araştırma makalesi { tbtkmedical148779, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2015}, volume = {45}, pages = {6 - 10}, doi = {10.3906/sag-1309-14}, title = {Utility of M30, an apoptotic serum marker, in liver diseases}, key = {cite}, author = {Altınbaş, Akif and Çoban, Şahin and Başar, Ömer and Yüksel, Osman} }
APA Altınbaş, A , Çoban, Ş , Başar, Ö , Yüksel, O . (2015). Utility of M30, an apoptotic serum marker, in liver diseases . Turkish Journal of Medical Sciences , 45 (1) , 6-10 . DOI: 10.3906/sag-1309-14
MLA Altınbaş, A , Çoban, Ş , Başar, Ö , Yüksel, O . "Utility of M30, an apoptotic serum marker, in liver diseases" . Turkish Journal of Medical Sciences 45 (2015 ): 6-10 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12385/148779>
Chicago Altınbaş, A , Çoban, Ş , Başar, Ö , Yüksel, O . "Utility of M30, an apoptotic serum marker, in liver diseases". Turkish Journal of Medical Sciences 45 (2015 ): 6-10
RIS TY - JOUR T1 - Utility of M30, an apoptotic serum marker, in liver diseases AU - Akif Altınbaş , Şahin Çoban , Ömer Başar , Osman Yüksel Y1 - 2015 PY - 2015 N1 - doi: 10.3906/sag-1309-14 DO - 10.3906/sag-1309-14 T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 6 EP - 10 VL - 45 IS - 1 SN - 1300-0144-1303-6165 M3 - doi: 10.3906/sag-1309-14 UR - https://doi.org/10.3906/sag-1309-14 Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Utility of M30, an apoptotic serum marker, in liver diseases %A Akif Altınbaş , Şahin Çoban , Ömer Başar , Osman Yüksel %T Utility of M30, an apoptotic serum marker, in liver diseases %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 1 %R doi: 10.3906/sag-1309-14 %U 10.3906/sag-1309-14
ISNAD Altınbaş, Akif , Çoban, Şahin , Başar, Ömer , Yüksel, Osman . "Utility of M30, an apoptotic serum marker, in liver diseases". Turkish Journal of Medical Sciences 45 / 1 (Mart 2015): 6-10 . https://doi.org/10.3906/sag-1309-14
AMA Altınbaş A , Çoban Ş , Başar Ö , Yüksel O . Utility of M30, an apoptotic serum marker, in liver diseases. Turkish Journal of Medical Sciences. 2015; 45(1): 6-10.
Vancouver Altınbaş A , Çoban Ş , Başar Ö , Yüksel O . Utility of M30, an apoptotic serum marker, in liver diseases. Turkish Journal of Medical Sciences. 2015; 45(1): 6-10.
IEEE A. Altınbaş , Ş. Çoban , Ö. Başar ve O. Yüksel , "Utility of M30, an apoptotic serum marker, in liver diseases", Turkish Journal of Medical Sciences, c. 45, sayı. 1, ss. 6-10, Mar. 2015, doi:10.3906/sag-1309-14

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