Eray ATALAY, Gül GÜRSOY, Fatih GÜNGÖR, Seyit Murat BAYRAM, Aslı ARAZ GÜNGÖR

The relationship of mean platelet volume with microalbuminuriain type 2 diabetic patients

Background/aim: Activation and size of platelets have been suggested to be involved in the pathogenesis of vascular complications in diabetes mellitus. The purpose of the present study was to investigate the association of mean platelet volume with microalbuminuria in type 2 diabetic patients. Materials and methods: Mean platelet volume levels were investigated in healthy participants and type 2 diabetic patients with and without microalbuminuria. After their mean platelet volume values were compared, correlation of mean platelet volume with sex, duration of diabetes, microalbuminuria, fasting blood glucose, hemoglobin A1c, creatinine clearance, and body mass index was examined. Results: Mean platelet volume levels were higher in all diabetic patients than those in controls. Mean platelet volume levels were highest in diabetics with microalbuminuria. The mean platelet volume levels had a positive correlation with microalbuminuria. Conclusion: Mean platelet volume values of diabetic patients were higher than those of nondiabetics, the highest levels being in diabetics with microalbuminuria. Our results suggest that microalbuminuria might be related with mean platelet volume in diabetic patients.

PDF

___

1. Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J 2001; 22: 15611571.
2. Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 , production and megakaryocyte nuclear DNA concentration. Thrombosis Research 1983; 21: 443460.
3. Ayhan S, Öztürk S, Erdem A, Özlü MF, Memioğlu T, Özyaşar M, Yazıcı M. Hematological parameters and coronary collateral circulation in patients with stable coronary artery disease. Exp Clin Cardiol 2013; 18: e12e15.
4. Ekici B, Erkan AF, Alhan A, Sayın I, Aylı M, Töre HF. Is mean platelet volume associated with the angiographic severity of coronary artery disease? Cardiol Pol 2013; 71: 832838.
5. Ghahremanfard F, Asgari N, Ghorbani R, Samaei A, Ghomi H, Tamadon M. The relationship between mean platelet volume and severity of acute ischemic brain stroke. Neurosciences (Riyadh) 2013; 18: 147151.
6. Verdioa M, Camaro C, Barbieri L, Schaffer A, Marino P, Bellomo G, Suryapranata H, De Luca G. Mean platelet volume and the risk of periprocedural myocardial infarction in patients undergoing coronary angioplasty. Atherosclerosis 2013; 228: 136141.
7. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, Mohler ER, Reilly MP, Berger JS. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010; 8: 148 156.
8. De Luca G, Santiagostino M, Secco GG, Cassetti E, Giuliani L, Franchi E, Coppo L, Iori S, Venegoni L, Rondano E et al. Mean platelet volume and the extent of coronary artery disease: results from a large prospective study. Arteriosclerosis 2009; 206: 292297.
9. Kalay N, Doğdu O, Koç F, Yarlıoğlues M, Ardıc I, Akpek M, Cicek D, Oguzhan A, Ergin A, Kaya MG. Hematologic parameters and angiographic progression of coronary atherosclerosis. Angiology 2012; 63: 213217.
10. Ntaios G, Gürer O, Faouzi M, Aubert C, Michael P. Mean platelet volume in the early phase of acute ischemic stroke is not associated with severity or functional outcome. Cerebrovasc Dis 2010; 29: 484489.
11. DErasmo E, Aliberti G, Celi FS, Romagnoli E, Vecci E, Mazzuoli GF. Platelet count, mean platelet volume and their relation to prognosis in cerebral infarction. J Intern Med 1990; 227: 1114.
12. OMalley T, Langhorne P, Elton RA, Stewart C. Platelet size in stroke patients. Stroke 1995; 26: 995999.
13. Kodiatte TA, Manikyam UK, Rao SB, Jadish TM, Reddy M, Lingaiah HK, Lakshmaiah V. Mean platelet volume in type 2 diabetes mellitus. J Lab Physicians 2012; 4: 59.
14. Jindal S, Gupta S, Gupta R, Kakar A, Singh HV, Gupta K, Singh S. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology 2011; 16: 8689.
15. Demirtunç R, Duman D, Başar M, Bilgi M, Teomete M, Garip T. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabetes Complications 2009; 23: 8994.
16. Bavbek N, Kargılı A, Kaftan O, Karakurt F, Koşar A, Akçay A. Elevated concentrations of soluble adhesion molecules and large platelets in diabetic patients: are they markers of vascular disease and diabetic nephropathy? Clin Appl Thromb Hemost 2007; 13: 391397.
17. Colwell JA. Vascular thrombosis in type II diabetes mellitus. Diabetes 1993; 42: 811.
18. Busby DE, Bakris GL. Comparison of commonly used assays for the detection of microalbuminuria. J Clin Hypertens 2004; 6: 812.
19. Bennett PH. The diagnosis of diabetes: new international classification and diagnostic criteria. Annu Rev Med 1983; 34: 295309.
20. Mancia G, De Backer G Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G. 2007 Guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25: 11051187.
21. Levey AS, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, Rossert J, De Zeeuw D, Hostter TH, Lameire N, Eknoyan G. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2005: 67: 20892100.
22. National Cholesterol Education Program. Detection, evaluation and treatment of high blood cholesterol in adults. Circulation 2002: 106: 31453421.
23. Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL 3rd, Klein R. Diabetic retinopathy. Position statement: Clinical practice recommendations 2003. Diabetes Care 2003; 26: S99S102.
24. Lauritzen T, Frost-Larsen K, Larsen HW, Deckert T. Two-year experience with continuous subcutaneous insulin infusion in relation to retinopathy and neuropathy. Diabetes 985; 34: 74 79.
25. Rose GA, Blackburn H. Cardiovascular Survey Methods. WHO Monogram Series, No. 56. Geneva, Switzerland: WHO; 1968.
26. Demirin H, Ozhan H, Ucgun T, Celer A, Bulur S, Cil H. Normal range of mean platelet volume in healthy subjects: insight from a large epidemiologic study. Thromb Res 2011; 128: 358360.
27. Hekimsoy Z, Payzin B, Örnek T, Kandoğan G. Mean platelet volume in type 2 diabetic patients. J Diabetes Complications 2004; 18: 173176.
28. Vinocour PD. Platelet abnormalities in diabetes mellitus. Diabetes 1992; 41: 2631.
29. Martyn CN, Matthews DM, Popp-Snijders C, Tucker J, Ewing DJ, Clarke BF. Effects of sorbinil treatment on erythrocytes and platelets of persons with diabetes. Diabetes Care 1986; 9: 3639.
30. Watanabe Y, Kawada M, Kobayashi B. Effect of insulin on murine megakaryocytopoiesis in a liquid culture system. Cell Struct Funct 1987; 12: 311316.
31. Guthikonda S, Alviar CL, Vaduganathan M, Arıkan M, Tellez A, DeLao T, Granada JF, Dong JF, Keiman NS, Lev EL. Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease. J Am Coll Cardiol 2008; 52: 743749.
32. Ünübol M, Ayhan M, Güney E. The relationship between mean platelet volume with microalbuminuria and glycemic control in patients with type II diabetes mellitus. Platelets 2012; 23: 475480.
33. Turgutalp K, Özhan O, Akbay E, Tombak A, Tiftik N, Özcan T, Yılmaz S, Helvacı İ, Kiykim A. Mean platelet volume and related factors in patients at different stages of diabetic nephropathy: a preliminary study. Appl Thromb Hemost 2014; 20: 190195.
34. Papanas N, Symonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T, Lakasas G. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004; 15: 475478.
35. Shah B, Sha D, Xie D, Mohler ER, Berger JS. The relationship between diabetes, metabolic syndrome and platelet activity as measured by mean platelet volume. Diabetes Care 2012; 35: 10741078.
36. Keskin S, Gürler M, Temeloğlu M, Çelebi A, Alicanoğlu R, Ekizoğlu I. Relation between mean platelet volume and risk factors for coronary heart disease. Turkiye Klinikleri J Med Sci 2006; 26: 380384.
37. Park Y, Schoene N, Haris W. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets 2002; 13: 301306.
38. Dindar S, Cinemre H, Sengül E, Annakaya AN. Mean platelet volume is associated with glycemic control and retinopathy in patients with type 2 diabetes mellitus. West Indian Med L 2013; 62: 519523.
39. Saigo K, Yasunaga M, Ryo R, Yamaguchi N. Mean platelet volume in diabetics. Rinsho Byori 1992; 40: 215217.
40. Sharpe PC, Thrink T. Mean platelet volume in diabetes mellitus. Q J Med 1993; 86: 739742.
41. Betteridge D, Zahavi J. Jones NAG, Shine B, Kakar VV, Galton DJ. Platelet function in diabetes mellitus in relationship to complications, glycosylated hemoglobin and serum lipoproteins. Eur J Clin Invest 1981; 11: 273277.
42. Tschoepe D, Roesen P, Esser J, Schwippert B, Nieuwenhuis HK, Kehrel B. Large platelets circulate in an activated state in diabetes mellitus. Semin Thromb Haemost 1991; 17: 433438.
43. Tschoepe D, Roesen P, Schwippert B, Gries FA. Platelets in diabetes: the role of hemostatic regulation in atherosclerosis. Semin Thromb Haemost 1993; 19: 122128.
44. Verdoia M, Schaffer A, Barbieri L, Cassetti E, Nardin M, Bellomo G, Marino P, Sinigaglia F, De Luca G; Novara Atherosclerosis Study (NAS) Group. Diabetes, glucose control and mean platelet volume: a single-centre cohort study. Diabetes Res Clin Pract 2014; 104: 288294.
45. Vinocour PD, Lopes-Virella MF, Laimins M, Colwell JA, Effect of insulin treatment in streptozocin induced diabetic rats on in vitro platelet function and plasma Von Willebrand factor activity and factor VIII related antigen. J Lab Clin Med 1985; 106: 319325.
46. Vinocour PD, Kinlough-Rathbone RL, Mustard JF. Pathways responsible for platelet hypersensitivity in rats with diabetes. II. Spontaneous diabetes in BB Wistar rats. J Lab Clin Med 1986; 107: 154158.
47. Tschoepe D, Ostermann H, Huebinger A, Ziegler D, Wiefels K, Gries FA. Elevated platelet activation in type 1 diabetics with chronic complications under long-term near normoglycemic control. Haemostasis 1990; 20: 9398.
48. Vernekar PV, Vaidya KL. Comparison of mean platelet volume in type 2 diabetics on insulin therapy and on oral hypoglycaemic agents. J Clin Diagn Res 2013; 7: 28392840.
49. Dolasık I, Senar SY, Celebi K, Aydın ZM, Korkmaz U, Cantürk Z. The effect of metformin on mean platelet volume in diabetic patients. Platelets 2012; 24: 118121.
50. Zdrojewski Z, Lizakowski S, Raszeja-Specht A, Skibowska A, Rutkowski B. Influence of spontaneous thrombocyte aggregation on progression of glomerular disease. Nephron 2002; 92: 3642.
51. Yarlioglues M, Kaya MG, Ardic I, Dogdu O, Kasapkara H, Gunter E, Akpek M, Kalay N, Doğan A, Ozdoğru I et al. Relationship between mean platelet volume levels and subclinical target organ damage in newly diagnosed hypertensive patients. Blood Pres 2011; 20: 9297.
52. Coban E, Özdoğan M, Yazıcıoğlu G, Akcit F. The mean platelet volume in patients with obesity. Int J Clin Pract 2006; 59: 981 982.
53. Coban E, Yılmaz A, Sarı R. The effect of weight loss on the mean platelet volume in obese patients. Platelets 2007; 18: 212216.
54. Muscari A, De Pascalis S, Cenni A, Ludovico C, Castaldini N, Antonelli S, Bianchi G, Magalotti D, Zolli M. Determinants of mean platelet volume in an elderly population: relevance of body fat, blood glucose and ischemic electrocardiographic changes. Thromb Haemost 2008; 99: 10791084.
55. Sivri N, Tekin G, Yatla K, Aksoy Y, Senen K, Yetkin E. Statins decrease mean platelet volume irrespective of cholesterol lowering effect. Kardiol Pol 2013; 71: 10421047.
56. Coban E, Adanır H, Bilgin D. The association of mean platelet volume levels in hypertensive retinopathy. Platelets 2008; 19: 115118.
57. Bulur S, Önder HI, Aslantaş Y, Ekinozu I, Kılıç AÇ, Yalçın S, Bulur S, Özhan H. Relation between indices of end-organ damage and mean platelet volume in hypertensive patients. Blood Coagul Fibrinolysis 2012; 23: 367369.
58. Celik T, Yuksel UC, Iyisoy A, Kursaklioglu H, Ozcan O, Kilic S, Ozmen N, Isik E. Effects of nebivolol on platelet activation in hypertensive patients: a comparative study with metoprolol. Int J Cardiol 2007; 116: 206211.
59. Demirtunç R, Duman D, Başar M. Effect of doxazocin and amlodipine on mean platelet volume and serum serotonin level in patients with metabolic syndrome: a randomised, controlled study. Clin Drug Investig 2007; 27: 435441.
60. Nufuez A, Gomez A, Zalba LR, Monton M, Jimenez A, Velasco S, Lopez-Blaya A, Uriarte C, Casado S, Lopez-Farre A. Losartan inhibits in vitro platelet activation: comparison with candesartan and valsartan. J Renin Angiotensin Aldosterone Syst 2000; 1: 175179.
61. Zhong ZL, Han M, Chen S. Risk factors associated with retinal neovascularisation of diabetic retinopathy in type 2 diabetes mellitus. Int J Ophthalmol 2011; 4: 182185.
62. Tuzcu AE, Arıca S, ilhan N, Dağlıoğlu M, Coşkun M, Ilhan O, Üstün I. Relationship between mean platelet volume and retinopathy in patients with type 2 diabetes. Graefes Arch Clin Exp Ophthalmol 2014; 252: 237240.
63. Xiao W, Huang Y, Dong J, Zhang X, Hu J. Relationship between platelet volume indices with macrovascular and peripheral neuropathy complications in type 2 diabetic patients. J Diabetes 2014; 6: 298303.
64. Papanas N, Mavridis G, Karavageli E, Symeonidis G, Maltezoa E. Peripheral neuropathy is associated with increased mean platelet volume in type 2 diabetic patients. Platelets 2005; 16: 498499.
65. Martin JF, Bath PMW, Burr ML. Influence of platelet size on outcome after myocardial infarction. Lancet 1991; 338: 1409 1411.
66. Hendra TJ, Oswald GA, Yudkin YS. Increased mean platelet volume after acute myocardial infarction relates to diabetes and to cardiac failure. Diabetes Res Clin Pr 1988; 5: 6369.
67. Lalouschek W, Lang W, Müler M; Vienna Stroke Study Group. Current strategies of secondary prevention after a cerebrovascular event: the Vienna stroke registry. Stroke 2001; 32: 28602866.