Cemalettin ALBAYI, Turgut İMİR, Kemal ÇEBER, Ayşegül YÜCEL

10598

The in Vitro Effect of Plasmodium berghei Antigen Lysate on Natural Killer (NK) Cell Cytotoxic Activity

Plasmodium berghei is the rodent equivalent of Plasmodium falciparum which causes cerebral malaria in humans. However, P. berghei does not cause cerebral malaria in BALB/c mice, instead it leads to parasitemia, fever and some degree of liver damage. Although different aspects of immunological response have been intensively investigated in malaria; this the first time the in vitro effect of P. berghei antigen lysate on murine NK cytotoxic activity was studied. It was observed that this parasite antigen lysate suppresed the cytolytic activity of NK cells in a dose-dependent manner. Because the suppression of NK cell activity in a dose-dependent manner by P. berghei antigen lysate is not in harmony with the fact that BALB/c mice is resistant to cerebral malaria caused by this parasite in other rodents, we concluded thet NK cell activity may not play a major role in this resistance.

Anahtar Kelimeler:

Natural killer (NK) cell, cytotoxicity, Plasmodium berghei.

The in Vitro Effect of Plasmodium berghei Antigen Lysate on Natural Killer (NK) Cell Cytotoxic Activity

Plasmodium berghei is the rodent equivalent of Plasmodium falciparum which causes cerebral malaria in humans. However, P. berghei does not cause cerebral malaria in BALB/c mice, instead it leads to parasitemia, fever and some degree of liver damage. Although different aspects of immunological response have been intensively investigated in malaria; this the first time the in vitro effect of P. berghei antigen lysate on murine NK cytotoxic activity was studied. It was observed that this parasite antigen lysate suppresed the cytolytic activity of NK cells in a dose-dependent manner. Because the suppression of NK cell activity in a dose-dependent manner by P. berghei antigen lysate is not in harmony with the fact that BALB/c mice is resistant to cerebral malaria caused by this parasite in other rodents, we concluded thet NK cell activity may not play a major role in this resistance.

Keywords:

Natural killer (NK) cell, cytotoxicity, Plasmodium berghei.,

Turkish Journal of Medical Sciences-Cover

ISSN: 1300-0144
Yayın Aralığı: 6
Yayıncı: TÜBİTAK

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