Kenan AYDOĞAN, Hayriye SARICAOĞLU, Emel BÜLBÜL BAŞKAN, Serkan YAZİCİ, Şükran TUNALI, Berrin GÜNAY

The efficacy of narrowband UVB treatment in pediatric vitiligo: a retrospective analysis of 26 cases

Background/aim: Narrowband UVB (Nb UVB) treatment is commonly used for the management of psoriasis and atopic dermatitis, and is less often used for vitiligo in children. The aim of this study was to evaluate the efficacy and short-term safety of Nb UVB phototherapy in children diagnosed with vitiligo retrospectively Materials and methods: A total of 26 patients younger than 18 years with the diagnosis of vitiligo and managed with Nb UVB phototherapy as documented in archive records were evaluated. Clinical response was assessed according to repigmentation of the lesions: good response when there was more than 75% repigmentation, moderate response when there was 25% 74% repigmentation, poor response when repigmentation was less than 24%, and unresponsive when there was no pigmentation and new lesions occurred. Results: A total of 26 patients received Nb UVB treatment; 14 were girls and 12 were boys. The age at onset of the disease varied between 2 and 18 years, with a mean age of onset of 10.07 ± 4.53 years. Repigmentation rate of >75% was detected in 45.4% of cases. Conclusion: Nb UVB phototherapy seems to be a well-tolerated effective and safe treatment option in children, especially those unresponsive to topical treatment and those with widespread lesions. However, long-term risks such as photocarcinogenesis and photoaging should kept in mind.

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1. Halder RM. Childhood vitiligo. Clin Dermatol 1997; 15: 899- 906.
2. Ersoy-Evans S, Altaykan A, Şahin S, Kölemen F. Phototherapy in childhood. Pediatr Dermatol 2008; 25: 599-605.
3. Sen BB, Rifaioglu EN, Ekiz O, Sen T, Celik E, Dogramaci AC. Narrow-band ultraviolet B phototherapy in childhood. Cutan Ocul Toxicol 2014; 33: 189-191.
4. Tan E, Lim D, Rademaker M. Narrowband UVB phototherapy in children: a New Zealand experience. Australas J Dermatol 2010; 51: 268-273.
5. Ezzedine K, Lim HW, Suzuki T, Katayama I, Hamzavi I, Lan CC, Goh BK, Anbar T, Silva de Castro C, Lee AY, et al. Vitiligo Global Issue Consensus Conference Panelists. Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference. Pigment Cell Melanoma Res 2012; 25: E1-13.
6. Brazzelli V, Prestinari F, Castello M, Bellani E, Roveda E, Barbagallo T, Borroni G. Useful treatment of vitiligo in 10 children with UVB narrowband (311 nm). Pediatr Dermatol 2005; 22: 257-261.
7. Lerner AB. Vitiligo. J Invest Dermatol 1959; 32: 285.
8. Gawkrodger DJ, Ormerod AD, Shaw L, Mauri-Sole I, Whitton ME, Watts MJ, Anstey AV, Ingham J, Young K; Therapy Guidelines and Audit Subcommittee et al. Guideline for the diagnosis and management of vitiligo. Br J Dermatol 2008; 159: 1051-1076.
9. Drake LA, Dinehart SM, Farmer ER, Goltz RW, Graham GF, Hordinsky MK, Lewis CW, Pariser DM, Skouge JW, Turner ML et al. Guidelines of care for vitiligo. J Am Acad Dermatol 1996; 35: 620-626.
10. Halder RM. Topical PUVA therapy for vitiligo. Dermatol Nursing 1991; 3: 178-180.
11. Westerhof W, Nieuweboer-Krobotova L. Treatment of vitiligo with UVB radiation versus topical psoralen plus UVA. Arch Dermatol 1997; 133: 1525-1528.
12. Njoo MD, Bos JD, Westerhof W. Treatment of generalized vitiligo in children with narrowband (TL-01) UVB radiation therapy. J Am Acad Dermatol 2000; 42: 245-253.
13. Kanwar AJ, Dogra S. Narrowband UVB for the treatment of generalized vitiligo in children. Clin Exp Dermatol 2005: 30; 332-336.
14. Percivalle S, Piccino R, Caccialanza M, Forti S. Narrowband UVB phototherapy in vitiligo: evaluation of results in 53 patients. G Ital Dermatol Venereol 2008; 143: 9-14.