Görkem KARAKAŞ UĞURLU, Mustafa UĞURLU, Serdar Süleyman CAN, Semra ULUSOY KAYMAK, Ali ÇAYKÖYLÜ, Şükran ERTEN

Effect of familial Mediterranean fever on sexual and reproductive health in women

Background/aim: The aim of this study was to investigate the relationship between familial Mediterranean fever and female sexual dysfunction and premenstrual syndrome. Materials and methods: This study included 36 patients with familial Mediterranean fever and 33 healthy volunteers. Familial Mediterranean fever was diagnosed according to the Tel Hashomer criteria and familial Mediterranean fever mutations were identified in all of the patients. The patients and healthy volunteers were compared in terms of anxiety, depression, sexual dysfunction, and premenstrual syndrome, and a model was created that describes the relationships among these variables. Results: We found statistically significant differences between the groups in terms of anxiety, premenstrual syndrome, and Golombok Rust Inventory of Sexual Satisfaction frequency and vaginismus subscale scores. There was no difference in depression scores between the groups. Conclusion: Familial Mediterranean fever is a rheumatic disease that predisposes patients to sexual dysfunction and premenstrual syndrome, which emerges as direct and indirect psychological factors.

PDF

___

1. Kollainis I, Ritis K, Moutsopoulos H. Familial Mediterranean fever associated pyrin mutations in Greece. Ann Rheum Dis 2003; 62: 479-481.
2. La Regina M, Nucera G, Diaco M, Procopio A, Gasbarrini G, Notarnicola C, Kone-Paut I, Touitou I, Manna R. Familial Mediterranean fever is no longer a rare disease in Italy. Eur J Hum Genet 2003; 11: 50-56.
3. Makay B, Emiroğlu N, Ünsal E. Depression and anxiety in children and adolescents with familial Mediterranean fever. Clin Rheumatol 2010; 29: 375-379.
4. Mijatovic V, Hompes PG, Wouters MG. Familial Mediterranean fever and its implications for fertility and pregnancy. Eur J Obstet Gyn R B 2003; 108: 171-176.
5. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-5®). Arlington, VA, USA: APA; 2013.
6. Raina R, Pahlajani G, Khan S, Gupta S, Agarwal A, Zippe CD. Female sexual dysfunction: classification, pathophysiology, and management. Fertil Steril 2007; 88: 1273-1284.
7. Dotters-Katz S, Kuller J, Price T. The impact of familial Mediterranean fever on womens health. Obstet Gynecol Surv 2012; 67: 357-364.
8. Rapkin A. A review of treatment of premenstrual syndrome & premenstrual dysphoric disorder. Psychoneuroendocrinology 2003; 28: 39-53.
9. Frank E, Severino S. Premenstrual dysphoric disorder: facts and meanings. J Pract Psychiatry Behav Health 1995; 1: 20-28.
10. Wittchen HU, Becker E, Lieb R, Krause P. Prevalence, incidence and stability of premenstrual dysphoric disorder in the community. Psychol Med 2002; 32: 119-132.
11. Campbell E, Peterkin D, OGrady K, Sanson-Fisher R. Premenstrual symptoms in general practice patients. Prevalence and treatment. J Reprod Med 1997; 42: 637-646.
12. Ugurlu GK, Erten S, Ugurlu M, Caykoylu A, Altunoğlu A. Sexual dysfunction in female patients with primary Sjögrens syndrome and effects of depression: cross-sectional study. Sex Disabil 2014; 32: 197-204.
13. de Moura Cal SFL, Alonso LC, de Almeida AG, Santiago MB, Miranda-Scippa Â. Association between premenstrual dysphoric disorder and systemic lupus erythematosus: exacerbation of major depression symptoms? Open Journal of Rheumatology and Autoimmune Diseases 2013; 3: 209-215.
14. Lara LADS, Silva ACJDS, Romão APMS, Junqueira FRR. Abordagem das disfunções sexuais femininas. Rev Bras Ginecol Obstet 2008; 30: 312-321 (in Portuguese).
15. Perdriger A, Solano C, Gossec L. Why should rheumatologists evaluate the impact of rheumatoid arthritis on sexuality? Joint Bone Spine 2010; 77: 493-495.
16. Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, Migdal A, Padeh S, Pras M. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 1997; 40: 1879-1885.
17. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961; 4: 561-571.
18. Hisli N. Beck Depresyon Envanterinin üniversite öğrencileri için geçerliği, güvenirliği. Psikoloji Dergisi 1989; 7: 3-13 (in Turkish).
19. Ulusoy M, Sahin N, Erkmen H. Turkish version of the Beck Anxiety Inventory: psychometric properties. J Cogn Psychother 1998; 12: 163-172.
20. Halbreich U, Endicott J, Schacht S, Nee J. The diversity of premenstrual changes as reflected in the Premenstrual Assessment Form. Acta Psychiatr Scand 1982; 65: 46-65.
21. Dereboy C, Dereboy I, Yigitol F, Coskun A. Psychometric data for the Premenstrual Assessment Form: a cluster analytic study. Turk Psikiyatri Derg 1994; 5: 83-90.
22. Rust J, Golombok S. The Golombok‐Rust inventory of sexual satisfaction (GRISS). Br J Clin Psychol 1985; 24: 63-64.
23. Tuğrul C, Öztan N, Kabakçı E. Golombok-Rust cinsel doyum ölçeğinin standardizasyon çalışması. Türk Psikiyatri Derg 1993; 4: 83-89 (in Turkish).
24. Oktay E, Akıncı MM, Karaaslan A. Research on the interaction of statistics with the courses in business administration curriculum with using path analysis. Atatürk University Journal of Graduate School of Social Sciences 2012; 16: 513- 527 (in Turkish with English abstract).
25. Şimşek Ö. Yapısal Eşitlik Uygulamalarına Giriş. Ankara, Turkey: Ekinoks Yayınları; 2007.
26. Lleras C. Path analysis. In: Kempf-Leonard K, editor. Encyclopedia of Social Measurement. Vol. 3. Amsterdam, the Netherlands: Elsevier; 2005. pp. 25-30.
27. Suhr D. Step your way through path analysis. In: Western Users of SAS Software Conference Proceedings; San Francisco, CA, USA; 2008.
28. Marchesoni D, Mozzanega B, De Sandre P, Romagnolo C, Gambari PF, Maggino T. Gynaecological aspects of primary Sjogrens syndrome. Eur J Obstet Gynecol Reprod Biol 1995; 63: 49-53.
29. Abdel-Nasser AM, Ali EI. Determinants of sexual disability and dissatisfaction in female patients with rheumatoid arthritis. Clin Rheumatol 2006; 25: 822-830.
30. van Berlo WT, van de Wiel HB, Taal E, Rasker JJ, Weijmar Schultz WC, van Rijswijk MH. Sexual functioning of people with rheumatoid arthritis: a multicenter study. Clin Rheumatol 2007; 26: 30-38.
31. Parıldar H, Sakallıoğlu O. Secondary amenorrhea as the presenting symptom of familial Mediterranean fever. Türkiye Aile Hekimliği Dergisi 2014; 18: 113-114 (in Turkish with English abstract).
32. Shohat M, Halpern GJ. Familial Mediterranean fever - a review. Genet Med 2011; 13: 487-498.
33. Majeed HA, Al-Qudah AK, Qubain H, Shahin HM. The clinical patterns of myalgia in children with familial Mediterranean fever. Semin Arthritis Rheum 2000; 30: 138-143.
34. Sahin S, Yalcin I, Senel S, Ataseven H, Uslu A, Yildirim O, Semiz M. Assesment life quality of familial Mediterranean fever patients by short form-36 and its relationship with disease parameters. Eur Rev Med Pharmacol Sci 2013; 17: 958-963.
35. Cook AJ, Brawer PA, Vowles KE. The fear-avoidance model of chronic pain: validation and age analysis using structural equation modeling. Pain 2006; 121: 195-206.
36. Koné-Paut I, Hentgen V, Touitou I. Current data on familial Mediterranean fever. Joint Bone Spine 2011; 78: 111-114.
37. Granat M, Tur-Kaspa I, Zylber-Katz E, Schenker JG. Reduction of peritoneal adhesion formation by colchicine: a comparative study in the rat. Fertil Steril 1983; 40: 369-372.
38. Ehrenfeld M, Brzezinski A, Levy M, Eliakim M. Fertility and obstetric history in patients with familial Mediterranean fever on long-term colchicine therapy. Br J Obstet Gynaecol 1987; 94: 1186-1191.
39. Koka S, Petro TM, Reinhardt RA. Estrogen inhibits interleukin1β-induced interleukin-6 production by human osteoblast-like cells. J Interferon Cytokine Res 1998; 18: 479-483.
40. Ben-Chetrit E, Levy M. Reproductive system in familial Mediterranean fever: an overview. Ann Rheum Dis 2003; 62: 916-919.
41. Kuczmierczyk AR, Adams HE, Calhoun KS, Naor S, Giombetti R, Cattalani M, McCann P. Pain responsivity in women with premenstrual syndrome across the menstrual cycle. Percept Mot Skills 1986; 63: 387-393.
42. Gerrits MM, van Oppen P, van Marwijk HW, Penninx BW, van der Horst HE. Pain and the onset of depressive and anxiety disorders. Pain 2014; 155: 53-59.
43. Sigmon ST, Whitcomb-Smith SR, Rohan KJ, Kendrew JJ. The role of anxiety level, coping styles, and cycle phase in menstrual distress. J Anxiety Disord 2004; 18: 177-191.
44. Nillni YI, Rohan KJ, Mahon JN, Pineles SL, Zvolensky MJ. The role of anxiety sensitivity in the experience of menstrualrelated symptoms reported via daily diary. Psychiatry Res 2013; 210: 564-569.
45. Fonnesu C, Cerquaglia C, Giovinale M, Curigliano V, Verrecchia E, de Socio G, La Regina M, Gasbarrini G, Manna R. Familial Mediterranean fever: a review for clinical management. Joint Bone Spine 2009; 76: 227-233.