Ersin ÇİMENTEPE, Mehmet Erol YILDIRIM, İlkay Bekir İNCEBAY, Ayşe ÇARLIOĞLU, Ömer Faruk KARATAŞ, Doğan ÜNAL

The effects of thyroid hormones on uroflowmetry parameters in asymptomatic women

To investigate whether there is any association between uroflowmetry parameters and blood levels of thyroid hormones in asymptomatic women. Materials and methods: Included in the study were 110 consecutive female patients with no urinary complaints who had thyroid function tests performed in an endocrinology clinic. Uroflowmetric measurements were performed for each patient in a sitting position. The patients were divided into 3 groups, hypo-, hyper-, and euthyroidism, and were investigated for statistical difference among them regarding maximum flow rate (Qmax), average flow rate (Qave), voided volume (VV), and voiding time (VT). Results: The mean Qmax and Qave values of hypo-, eu-, and hyperthyroid groups were 25.3 ± 9.1 and 14.9 ± 5.8, 28.6 ± 9.6 and 16.2 ± 6.4, and 21.5 ± 8.7, and 13.2 ± 5.6, respectively. In the evaluation of all groups, a statistically significant difference was found regarding Qmax (P = 0.004) and Qave (P = 0.024). When the groups were evaluated between each other, Qmax (p = 0.003) and Qave (P = 0.027) were significantly different between hyper- and euthyroid groups, with no statistically significant differences in other groups regarding the uroflowmetry parameters (P > 0.05). Conclusion: It has been found that Qmax and Qave were significantly lower in the hyperthyroid group as compared with the euthyroid group. According to these findings, it may be thought that hyperthyroidism negatively affects uroflowmetry parameters. To reach a definitive judgment, more investigations supported by urodynamic studies are necessary.

Anahtar Kelimeler:

Key words: uroflowmetry, thyroid hormone, urination

The effects of thyroid hormones on uroflowmetry parameters in asymptomatic women

Keywords:

Key words: uroflowmetry, thyroid hormone, urination,

PDF

___

Hergenç G, Onat A, Albayrak S, Karabulut A, Türkmen S, Sarı İ et al. TSH levels in Turkish adults: prevalences and associations with serum lipids, coronary heart disease, and metabolic syndrome. Turk J Med Sci 2005; 35: 297–304.
Hızlı Ş, Arslan N, Abacı A, Büyükgebiz B. Subclinical hypothyroidism in obese Turkish adolescents: the relationship with anthropometry and fatty liver. Turk J Med Sci 2010; 40: 287–92.
Çetinkaya K, İngeç M, Çetinkaya S, Kaplan İ. Iodine deficiency in pregnancy and in women of reproductive age in Erzurum, Turkey. Turk J Med Sci 2012; 42: 675–80.
Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002; 87: 489–99.
Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F et al. The spectrum of thyroid disease in a community: the Whickham survey. Clinical Endocrinology 1977; 7: 481–93.
Flynn RWV, MacDonald TM, Morris AD, Jung RT, Leese GP. The thyroid epidemiology, audit and research study: thyroid dysfunction in the general population. J Clin Endocrinol Metab 2004; 89: 3879–84.
De Groat WC. Integrative control of the lower urinary tract: preclinical perspective. Br J Pharmacol 2006; 147 Suppl 2: S25–40.
Silva JE, Bianco SD. Thyroid-adrenergic interactions: physiological and clinical implications. Thyroid 2008; 18: 157–65.
Unsal A, Cimentepe E. Voiding position does not affect uroflowmetric parameters and post-void residual urine volume in healthy volunteers. Scand J Urol Nephrol 2004; 38: 469–71.
Burggraaf J, Tulen JH, Lalezari S, Schoemaker RC, De Meyer PH, Meinders AE et al. Sympathovagal imbalance in hyperthyroidism. Am J Physiol Endocrinol Metab 2001; 281: E190–5.
Hess ME, Barasha B, Winters S, Levin RM. Effect of thyroxine on urinary bladder receptor densities and contractility. Pharmacology 1993; 46: 248–53.
Ho CH, Chang TC, Guo YJ, Chen SC, Yu HJ, Huang KH. Lower urinary tract symptoms and urinary flow rates in female patients with hyperthyroidism. Urology 2011; 77: 50–4.
Andersen LF, Agner T, Walter S, Hansen JM. Micturition pattern in hypothyroidism and hyperthyroidism. Urology 1987; 29: 223–4.
Nathan AW, Havard CW. Paralytic ileus and urinary retention due to hypothyroidism. Br Med J 1982; 14: 477.
Martinez JM, Guardia J, Valaseca J, Bacardi R, Tornos J. Myxoedema and retention of urine. Br Med J 1972; 2: 549–50.