Kürşat DİKMEN, Asiye Uğraş DİKMEN, Hasan BOSTANCI, Ahmet KARAMERCAN, Abdullah Münci YAĞCI, Murat AKIN, Bülent AYTAÇ

The effect of pneumoperitoneum on intravascular fibrinolytic activity in rats

Öz Background/aim: Venous stasis during pneumoperitoneum in laparoscopic surgery is closely related to fibrin synthesis and deposition. The etiologic factors underlying fibrinolysis or hypercoagulability are not clearly defined. This study aimed to determine the effects of pneumoperitoneum time and pressure on coagulation cascade and the fibrinolytic pathway. Materials and methods: After the pneumoperitoneum model was established in rats, PAI-1, tPA, TAFI, D-dimer, and fibrinogen activities were evaluated in different time periods under different pressures in groups including 6 rats. Group 1 did not undergo any procedure. Group 2 received 8 mmHg of pressure for 30 min, Group III 8 mmHg for 60 min, Group IV 12 mmHg for 30 min, and Group V 12 mmHg for 60 min. Results: D-dimer levels had a tendency to decrease with increasing intraabdominal pressures. In both low and high pressure groups, fibrinogen had a tendency to increase with exposure time. There was no statistically significant difference among the study groups in terms of fibrinogen, D-dimer, and PAI-1. The levels of TAFI were significantly decreased with increasing pressure regardless of the exposure time. Conclusion: Pneumoperitoneum of the coagulation system can be changed by duration of time and pressure.

Anahtar Kelimeler:

Pneumoperitoneum, fibrinolysis, hypercoagulability

Tam Metin

Kaynak Göster

Bibtex	`@ { tbtkmedical575952, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2016}, volume = {46}, pages = {1528 - 1533}, doi = {}, title = {The effect of pneumoperitoneum on intravascular fibrinolytic activity in rats}, key = {cite}, author = {Dikmen, Kürşat and Dikmen, Asiye Uğraş and Bostancı, Hasan and Karamercan, Ahmet and Yağcı, Abdullah Münci and Akın, Murat and Aytaç, Bülent} }`
APA	Dikmen, K , Dikmen, A , Bostancı, H , Karamercan, A , Yağcı, A , Akın, M , Aytaç, B . (2016). The effect of pneumoperitoneum on intravascular fibrinolytic activity in rats . Turkish Journal of Medical Sciences , 46 (5) , 1528-1533 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45675/575952
MLA	Dikmen, K , Dikmen, A , Bostancı, H , Karamercan, A , Yağcı, A , Akın, M , Aytaç, B . "The effect of pneumoperitoneum on intravascular fibrinolytic activity in rats" . Turkish Journal of Medical Sciences 46 (2016 ): 1528-1533 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45675/575952>
Chicago	Dikmen, K , Dikmen, A , Bostancı, H , Karamercan, A , Yağcı, A , Akın, M , Aytaç, B . "The effect of pneumoperitoneum on intravascular fibrinolytic activity in rats". Turkish Journal of Medical Sciences 46 (2016 ): 1528-1533
RIS	TY - JOUR T1 - The effect of pneumoperitoneum on intravascular fibrinolytic activity in rats AU - Kürşat Dikmen , Asiye Uğraş Dikmen , Hasan Bostancı , Ahmet Karamercan , Abdullah Münci Yağcı , Murat Akın , Bülent Aytaç Y1 - 2016 PY - 2016 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1528 EP - 1533 VL - 46 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote	%0 Turkish Journal of Medical Sciences The effect of pneumoperitoneum on intravascular fibrinolytic activity in rats %A Kürşat Dikmen , Asiye Uğraş Dikmen , Hasan Bostancı , Ahmet Karamercan , Abdullah Münci Yağcı , Murat Akın , Bülent Aytaç %T The effect of pneumoperitoneum on intravascular fibrinolytic activity in rats %D 2016 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 46 %N 5 %R %U
ISNAD	Dikmen, Kürşat , Dikmen, Asiye Uğraş , Bostancı, Hasan , Karamercan, Ahmet , Yağcı, Abdullah Münci , Akın, Murat , Aytaç, Bülent . "The effect of pneumoperitoneum on intravascular fibrinolytic activity in rats". Turkish Journal of Medical Sciences 46 / 5 (Ekim 2016): 1528-1533 .
AMA	Dikmen K , Dikmen A , Bostancı H , Karamercan A , Yağcı A , Akın M , Aytaç B . The effect of pneumoperitoneum on intravascular fibrinolytic activity in rats. Turkish Journal of Medical Sciences. 2016; 46(5): 1528-1533.
Vancouver	Dikmen K , Dikmen A , Bostancı H , Karamercan A , Yağcı A , Akın M , Aytaç B . The effect of pneumoperitoneum on intravascular fibrinolytic activity in rats. Turkish Journal of Medical Sciences. 2016; 46(5): 1528-1533.
IEEE	K. Dikmen , A. Dikmen , H. Bostancı , A. Karamercan , A. Yağcı , M. Akın ve B. Aytaç , "The effect of pneumoperitoneum on intravascular fibrinolytic activity in rats", Turkish Journal of Medical Sciences, c. 46, sayı. 5, ss. 1528-1533, Eki. 2016