Burak Veli ÜLGER, Ömer PARLAK, Samet YALÇIN, Ahmet KUŞDEMİR, Mehmet ÖZER, Ali Erkan UÇAR, Birol KORUKLUOĞLU, Seyyit Muhsin SARIKAYA, Bülent YALÇIN

Th e role of preoperative serum thyroglobulin and thyroid auto-antibody levels before histopathological diagnosis of thyroid cancers

Amaç: Unilateral tiroid nodül cerrahisi sırasında frozen section işlemi yapılamadığı durumlarda, kanser olması durumunda, hastaların yeniden ameliyat olması gerekebilmektedir. Bu nedenle, tiroid nodüllerinde preoperatif malignitenin tesbitinde, serum tiroid otoantikor seviyelerinin yeri araştırıldı. Yöntem ve gereç: Retrospektif olarak, tiroidektomi yapılmış olan hastaların preoperatif serum tiroglobulin (Tg), antitiroglobulin antikoru (anti-Tg) ve anti-tiroid peroksidaz antikoru (anti-TPO) düzeyleri ile tiroid kanserleri arasında bir ilişki olup olmadığını araştırıldı. Bulgular: İki yıl içinde preoperatif serum Tg, anti-Tg ve anti-TPO seviyeleri bakılmış ve tiroid cerrahisi yapılmış 287 hasta çalışmaya alındı. Hastaların sadece 54 (% 18,8)’ünde postoperatif histopatolojik tiroid malignitesi tanısı aldı. Postoperatif tiroid kanseri saptanan bu hastaların 16 (% 29,6) ‘inde serum Tg, anti-TPO ve/veya anti-Tg seviyeleri yüksek bulundu. Yüksek serum Tg düzeyi saptanma oranı benign grupta yüksekti (% 49,4 vs % 31,5 , P = 0,018).Sonuç: Malign tiroid hastalıklarını önceden tahmin etmede serum Tg, anti-TPO ve anti-Tg seviyelerinin ölçümü yardımcı bir yöntem değildir.

Tiroid kanserlerinin histopatolojik tanı öncesinde serum tiroglobülin ve tiroid oto-antikorları seviyelerinin rolü

Aim: If a frozen section pathological examination is not performed in unilateral thyroid nodule surgery and the postoperative pathological diagnosis is cancer, a second operation may be required. Th erefore, it was studied whether serum thyroid auto-antibody levels are useful or not in determining preoperative malignancy in patients with thyroid disorders. Materials and methods: It was investigated retrospectively whether there was a correlation between preoperative serum thyroglobulin (Tg), anti-thyroglobulin antibody (anti-Tg), and anti-thyroid peroxidase antibody (anti-TPO) levels and thyroid cancer in patients who had undergone thyroidectomy. Results: Two hundred and eighty-seven patients who had undergone thyroid surgery and whose preoperative serum levels of Tg, anti-Tg, and anti-TPO had been recorded were included in this study. Only 54 (18.8%) of the patients had a malignant diagnosis in the postoperative histopathological examination. Sixteen of the patients who had a postoperative malignant thyroid disease diagnosis (29.6%) had high serum Tg, anti-TPO, and/or anti-Tg levels. Th e rate of high serum Tg levels was signifi cant in patients with a benign pathology (49.4% vs. 31.5%, P = 0.018). Conclusion: It appears that preoperative measurement of serum Tg, anti-TPO, and anti-Tg levels is not a useful method to predict malign thyroid diseases.

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