Murat AYDIN, Cemile KOCA, Sema UYSAL, Yüksel TOTAN, Ramazan YAĞCI, Ferah ARMUTCU, Zübeyde CÜCEN, M. Ramazan YİĞİTOĞLU

137136

Serum nitric oxide, asymmetric dimethylarginine, and plasma homocysteine levels in active Behçet's disease

Behçet's disease is a relapsing vasculitis characterized by endothelial dysfunction. This study was conducted to determine the levels of nitric oxide (NO) and 2 related parameters, asymmetric dimethylarginine (ADMA) and homocysteine levels, in relation to the pathogenesis of Behçet's disease. Materials and methods: A total of 49 Behçet's patients, comprising 26 patients with the active disease and 23 patients with the inactive disease, and a healthy control group of 24 individuals participated in this study. International Study Group Diagnostic Criteria were followed in the diagnosis of Behçet's disease; patients who had at least 2 signs were considered as having the active disease. Results: Serum NO and plasma homocysteine levels were found to be significantly higher in patients with active Behçet's disease compared to patients with inactive Behçet's disease and healthy controls. In active and inactive Behçet's patients, serum ADMA levels were significantly higher than those of healthy controls. No statistically significant difference was found between patients with inactive Behçet's and healthy controls with respect to serum homocysteine levels. Conclusion: The increased serum levels of ADMA presumably cause endothelial dysfunction because of a deficiency in NO production, which also appears to be involved in the vasculitis of Behçet's disease.
Anahtar Kelimeler:

Key words: Nitric oxide, asymmetric dimethylarginine, homocysteine, Behçet's disease

Serum nitric oxide, asymmetric dimethylarginine, and plasma homocysteine levels in active Behçet’s disease

Behçet's disease is a relapsing vasculitis characterized by endothelial dysfunction. This study was conducted to determine the levels of nitric oxide (NO) and 2 related parameters, asymmetric dimethylarginine (ADMA) and homocysteine levels, in relation to the pathogenesis of Behçet's disease. Materials and methods: A total of 49 Behçet's patients, comprising 26 patients with the active disease and 23 patients with the inactive disease, and a healthy control group of 24 individuals participated in this study. International Study Group Diagnostic Criteria were followed in the diagnosis of Behçet's disease; patients who had at least 2 signs were considered as having the active disease. Results: Serum NO and plasma homocysteine levels were found to be significantly higher in patients with active Behçet's disease compared to patients with inactive Behçet's disease and healthy controls. In active and inactive Behçet's patients, serum ADMA levels were significantly higher than those of healthy controls. No statistically significant difference was found between patients with inactive Behçet's and healthy controls with respect to serum homocysteine levels. Conclusion: The increased serum levels of ADMA presumably cause endothelial dysfunction because of a deficiency in NO production, which also appears to be involved in the vasculitis of Behçet's disease.
Keywords:

asymmetric dimethylarginine, homocysteine, Behçet's disease, Nitric oxide,

PDF
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Arşiv
Sayıdaki Diğer Makaleler

The effect of palonosetron on postoperative nausea and vomiting in supratentorial craniotomy patients

Halit MADENOĞLU, Cihan AKDEMİR, Recep AKSU, Cihangir BİÇER, Ayşe ÜLGEY, Adem BOYACI

2-[18f]-Fluoro–2-deoxy-d-glucose positron emission tomography in the evaluation of breast lesions and axillary involvement: a comparison with mammography and histopathological diagnosis

Oğuz HANÇERLİOĞULLARI, Nuri ARSLAN, Semih GÖRGÜLÜ, Mehmet Fatih CAN, Hanife Aslı Ayan EKE, Semra İNCE, Erkan ÖZTÜRK, Ramazan YILDIZ, Mehmet Ali ÖZGÜVEN

Genotyping of Giardia intestinalis isolated from people living in Sivas, Turkey

Serpil DEĞERLİ, Naci DEĞERLİ, Ali ÇELİKSÖZ, Semra ÖZÇELİK

Histopathological effects of S. xylosus peptidoglycan in comparison to E. coli lipopolysaccharide in the urinary tract of mice

Harith Jabbar Fahad AL-MATHKHURY, May Talib FLAIH, Hiba Khalil TAWFIQ

The impact of attention training on children with low vision: a randomized trial

Bilge Başakci ÇALIK, Ali KİTİŞ, Uğur CAVLAK, Attila OĞUZHANOĞLU

Effects of androgen on expression of OMgp of the HIBD neonatal rat brain

Manling LIU, Zhankui LI

Serum nitric oxide, asymmetric dimethylarginine, and plasma homocysteine levels in active Behçet's disease

Murat AYDIN, Cemile KOCA, Sema UYSAL, Yüksel TOTAN, Ramazan YAĞCI, Ferah ARMUTCU, Zübeyde CÜCEN, M. Ramazan YİĞİTOĞLU

Comparison of three volumetric techniques for estimating thyroid gland volume

Ümit Erkan VURDEM, Niyazi ACER, Tolga ERTEKİN, Ahmet SAVRANLAR, Ömer TOPUZ, Mustafa KEÇELİ

Comparison of the outcomes of the TOT technique using a hand-made TOT material and a commercial one

Ahmet Tunç ÖZDEMİR, Serkan ALTINOVA, Hacı İbrahim ÇİMEN, Ege Can ŞEREFOĞLU, Hasbey Hakan KOYUNCU, Mesut GÜRDAL

Results of robotic radical prostatectomy in the hands of surgeons without previous laparoscopic radical prostatectomy experience

Abdullah Erdem CANDA, Ali Fuat ATMACA, Ziya AKBULUT, Erem ASİL, Metin KILIÇ, Abidin Egemen İŞGÖREN, Mevlana Derya BALBAY