Özlem YAVUZ, Cahit BİLGİN, Beşir ERDOĞMUŞ, Peri Meram ARBAK, Ramazan MEMİŞOĞULLARI, Hamit Hakan ALP

Serum homacysteine levels in highway toll collectors and the relationship with intima-media thickness of the carotid artery

Amaç: Son zamanlarda hava kirliliği ve artmış intima-media kalınlığı (IMT) arasında bir ilişki olduğu rapor edilmiş, ancak etyolojisi tam olarak anlaşılamamıştır. Biz bu çalışmada önemli hava kirleticiler olan egsoz partiküllerine maruziyetin artmış homosistein (Hey) düzeyleriyle ilişkisi olup olmadığını ve artmış homosistein düzeylerinin artmış intima-media kalınlığı ile ilişkili olup olmadığını araştırdık. Yöntem ve Gereç: Altmışbeş erkek otoyol gişe memuru ve 43 sağlıklı erkek gönüllüde yüksek performanslı sıvı kromatografısi ile serum Hey düzeyleri ölçüldü. IMT ise Doppler Sonografi kullanılarak deneyimli bir radyolog tarafından ölçüldü. Bulgular: Otoyol gişe memurlarında serum Hey düzeyleri (14.5 ± 4.9 mmol/1, P < 0.005) ve IMT (0.757 ± 0.18 mm, P < 0.001) kontrollerden daha yüksekti (sırasıyla; 12.0 ± 2.8 mmol/1 ve 0.612 ±0.11 mm). Hem otoyol gişe memurları grubunda (r = 0.36; P < 0.005) ve hem de kontrol grubunda (r = 0.36; P < 0.05) Hey ve IMT arasında pozitif bir korelasyon bulundu. Sonuç: Egsoz partiküllerine maruziyet, sonuçta bir IMT artışına yol açabiîen Hey düzeyinde bir artıştan dolayı, oksidatif stres artışına neden olabilir. Ancak son karara varmadan önce hala daha ileri çalışmalara ihtiyaç vardır.

Otoyol gişe memurlarında serum homosistein düzeyleri ve karotis arterinde intima-media kalınlığı ile ilişkisi

Aim: A relationship between air pollution and increased intima-media thickness (IMT) has been recently reported, but its etiology is not yet well understood. We aimed to determine whether exposure to exhaust particles, which are important air pollutants, is associated with increased serum homocysteine (Hey) levels and whether elevated Hey levels are associated with increased IMT. Materials and Methods: Serum Hey levels were measured by fluorometric high performance liquid chromatography in 65 male highway toll collectors (HTCs) and 43 healthy male volunteers. IMT was measured with Doppler sonography by an experienced radiologist. Results: Serum Hey levels (14.5 ± 4.9 mmol/L, P < 0.005) and IMT (0.757 ±0.18 mm, P < 0.001) were higher in the HTC group than in controls (12.0 ± 2.8 mmol/L and 0.612 ± 0.11 mm, respectively). A positive correlation was found between Hey level and IMT both in the HTC group (r = 0.36; P < 0.005) and in the control group (r = 0.36; P < 0.05). Conclusions: Exposure to exhaust particles may cause an increase in oxidative stress because of an increase in serum Hey levels, which consequently may lead to an increase in IMT. Nevertheless, further studies on the subject are needed before drawing a firm conclusion.

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