Prevalence and risk factors of restless leg syndrome in a single hemodialysis unit

Restless legs syndrome (RLS) is characterized by symptoms of spontaneous, continuous leg movements associated with unpleasant paresthesias. RLS is common among dialysis patients, with a reported incidence of 6.6 to 6.8 percent. This study is an attempt to find out the prevalence of RLS in our hemodialysis patients. We compared several demographic and clinical characteristics of RLS patients identified by the International Restless Legs Syndrome Study Group (IRLSSG) criteria with those of individuals without RLS. Materials and methods: We studied 76 patients with end-stage renal disease (ESRD) on hemodialysis (34 females and 42 males, mean age: 52.28 ± 18.13, range: 18-83 years). RLS patients' diagnoses were confirmed using the IRLSSG criteria. RLS is diagnosed when a patient answered positively to all of the 4 questions. Hemoglobin, ferritin, iron, iron binding capacity, PTH, and Kt/V ratio values were measured. Results: We found an RLS frequency of 14.5% in our sample. There was no significant difference in terms of serum iron, ferritin, creatinine, iPTH, hemoglobin, and Kt/V between groups of hemodialysis patients with and without RLS (P = 0.89, 0.87, and 0.37, respectively). Conclusion: The 14.5% prevalence of RLS in hemodialysis patients was lower than that has been reported previously. The variability in RLS prevalence rates among hemodialysis patients may result from some racial, regional, socioeconomic, or ethnic differences. These findings need to be confirmed in larger studies.

Prevalence and risk factors of restless leg syndrome in a single hemodialysis unit

Restless legs syndrome (RLS) is characterized by symptoms of spontaneous, continuous leg movements associated with unpleasant paresthesias. RLS is common among dialysis patients, with a reported incidence of 6.6 to 6.8 percent. This study is an attempt to find out the prevalence of RLS in our hemodialysis patients. We compared several demographic and clinical characteristics of RLS patients identified by the International Restless Legs Syndrome Study Group (IRLSSG) criteria with those of individuals without RLS. Materials and methods: We studied 76 patients with end-stage renal disease (ESRD) on hemodialysis (34 females and 42 males, mean age: 52.28 ± 18.13, range: 18-83 years). RLS patients' diagnoses were confirmed using the IRLSSG criteria. RLS is diagnosed when a patient answered positively to all of the 4 questions. Hemoglobin, ferritin, iron, iron binding capacity, PTH, and Kt/V ratio values were measured. Results: We found an RLS frequency of 14.5% in our sample. There was no significant difference in terms of serum iron, ferritin, creatinine, iPTH, hemoglobin, and Kt/V between groups of hemodialysis patients with and without RLS (P = 0.89, 0.87, and 0.37, respectively). Conclusion: The 14.5% prevalence of RLS in hemodialysis patients was lower than that has been reported previously. The variability in RLS prevalence rates among hemodialysis patients may result from some racial, regional, socioeconomic, or ethnic differences. These findings need to be confirmed in larger studies.

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  • Yuksel S, Colbay M, Yaman M, Uslan I, Acarturk G, Karaman O. Evaluation of diagnostic criteria of restless leg syndrome in hemodialysis patients. Eur J Gen Med. 2007; 4: 145-8.
  • Nikić PM, Andrić BR, Stojanović-Stanojević M, Dordević V, Petrović D, Stojimirović BB. Restless legs syndrome prevalence in patients on chronic hemodialysis in central Serbia. Vojnosanit Pregl. 2007; 64: 129-34.
  • Mucsi I, Molnar MZ, Ambrus C, Szeifert L, Kovacs AZ, Zoller R et al. Restless legs syndrome, insomnia and quality of life in patients on maintenance dialysis. Nephrol Dial Transplant. 2005; 20: 571-7.
  • Gigli GL, Adorati M, Dolso P, Piani A, Valente M, Brotini S et al. Restless legs syndrome in end-stage renal disease. Sleep Med. 2004; 5: 309-15.
  • Bhowmik D, Bhatia M, Tiwari S, Mahajan S, Gupta S, Agarwal SK et al. Low prevalence of restless legs syndrome in patients with advanced chronic renal failure in the Indian population: a case controlled study. Ren Fail. 2004; 26: 69-72.
  • Bhowmik D, Bhatia M, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Restless legs syndrome in hemodialysis patients in India: a case controlled study. Sleep Med. 2003; 4: 143-6.
  • Goffredo Filho GS, Gorini CC, Purysko AS, Silva HC, Elias IE. Restless legs syndrome in patients on chronic hemodialysis in a Brazilian city: frequency, biochemical findings and comorbidities. Arq Neuropsiquiatr. 2003; 3B: 723-7.
  • Sloand JA, Shelly MA, Feigin A, Bernstein P, Monk RD. A. double-blind, placebo-controlled trial of intravenous iron dextran therapy in patients with ESRD and restless legs syndrome. Am J Kidney Dis. 2004; 43: 663-70.
  • Earley CJ, Connor JR, Beard JL, Malecki EA, Epstein DK, Allen RP. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology 2000; 54: 1698– 700.
  • Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ. MRI measurement of brain iron in patients with restless legs syndrome. Neurology 2001; 56: 263–5.
  • Berger K, von Eckardstein A, Trenkwalder C, Rothdach A, Junker R, Weiland SK. Iron metabolism and the risk of restless legs syndrome in an elderly general population: the MEMO- Study. J Neurol. 2002; 249: 1195– 9.
  • Miranda M, Araya F, Castillo JL, Durán C, González F, Arís L. Restless legs syndrome: a clinical study in adult general population and in uremic patients. Rev Med Chil. 2001; 129: 179-86.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

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Transthoracic lung and mediastinal biopsies obtained with the Tru-Cut technique: 10 years’ experience

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