İbrahim ŞAHİN, Süleyman AYDIN, İsmail TEMEL, Nilüfer ÇELİK, Şeyma HASÇALIK, Önder ÇELİK

Polikistik over sendromlu kadınlarda serum nonesterifiye yağ asitleri, grelin ve homosistein düzeyleri

Amaç: Nonesterifiye yağ asitleri (NEFA), grelin ve homosistein serum düzeyleri ile polikistik over sendromlu (PCOS)kadınların metabolik ve hormonal özellikleri arasındaki ilişkileri araştırmak.Yöntem ve gereç: PCOS’lu 30 kadın ile benzer yaş ve vucut kitle indeksi (BMI) ne sahip sağlıklı 30 kadın çalışmaya dahiledildi. Açlık serum NEFA, grelin, homosistein, büyüme hormonu (GH), kardiyak troponin I, glukoz, insülin, lipitler vehomeostasis model assessment-insülin direnci (HOMA-IR) testleri çalışıldı.Bulgular: Kontrole kıyasla PCOS’lu kadınlarda serum NEFA, homosistein, insulin, HOMA-IR, kolesterol ve testosterondüzeyleri önemli oranda yüksek fakat grelin seviyesi düşük bulundu. Gruplar arasında troponin I ve GH düzeyleriyönünden fark bulunamadı. İnsülin-NEFA ve insülin-homosistein düzeyleri arasında istatiksel anlamlı ve pozitifkorelasyon saptanırken, grelin-insülin ve grelin-homosistein parametreleri arasında anlamlı bir korelasayon saptanmadı.Sonuç: Azalmış grelin, yüksek NEFA ve homosistein düzeyleri; açlık insülin düzeyleri ile NEFA ve homosistein düzeyleriarasındaki korelasyonlar PCOS patogenezinde önemli rol oynayabilir. Bu sonuçlar daha büyük prospektif ve kontrollüçalışmalar ile konfirme edilmelidir.

Anahtar Kelimeler:

NEFA, grelin, homosistein, insülin, PCOS

Serum nonesterified fatty acids, ghrelin, and homocysteine levels in women with polycystic ovary syndrome

To investigate the possible relationship of serum levels of nonesterified fatty acids (NEFA), ghrelin, and homocysteine levels to metabolic and hormonal features in women with polycystic ovary syndrome (PCOS). Materials and methods: Thirty women with PCOS and 30 healthy women with similar age and body mass index (BMI) were recruited. Fasting serum NEFA, ghrelin, homocysteine, growth hormone (GH), cardiac troponin I, glucose, insulin, lipids, and homeostasis model assessment of insulin resistance (HOMA-IR) were measured. Results: Serum NEFA, homocysteine, insulin, HOMA-IR, cholesterol, and testosterone levels were significantly higher but in contrast ghrelin level was significantly lower in women with PCOS compared to the controls. No significant differences were found in the troponin I and GH levels between the 2 groups. Significant positive correlations between insulin-NEFA and insulin-homocysteine levels were observed. There was no significant correlation between ghrelin-insulin and ghrelin-homocysteine levels. Conclusion: The decreased ghrelin, elevated NEFA and homocysteine levels, and the correlation of NEFA and homocysteine to fasting insulin level might play an important role in the pathogenesis of the PCOS. These findings need to be confirmed and larger prospective and controlled studies are necessary.

Keywords:

ghrelin, homocysteine, insulin, PCOS, NEFA,

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