Hülya YIKILKAN, Cenk AYPAK, Süleyman GÖRPELİOĞLU, Murat DİCLE, Özde ÖNDER

Parathyroid hormone and optimal vitamin D status in postmenopausal women

Low serum vitamin D and calcium levels as well as high parathyroid hormone (PTH) levels are the most important risk factors in osteoporosis. The aim of our study was to estimate the optimal vitamin D status needed to prevent a rise in PTH concentrations in postmenopausal women. Materials and methods: A total of 197 postmenopausal women who were at the menopausal period for at least 1 year and who had body mass indexes (BMIs) 70 years). Results: The mean age of patients was 60.8 ± 10.9 years. Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were lower than 10 ng/mL in 94 patients (47.7%) and lower than 20 ng/mL in 167 (84.8%) patients. The mean vitamin D level was lowest in group 2 (51-60 years), but the difference was not statistically significant (P = 0.57). PTH levels were higher than 75 pg/dL in 52 patients, and 65.4% of those patients (n = 34) had vitamin D insufficiency (

Anahtar Kelimeler:

Key words: Osteoporosis, menopause, vitamin D, parathyroid hormone

Parathyroid hormone and optimal vitamin D status in postmenopausal women

Keywords:

Key words: Osteoporosis, menopause, vitamin D, parathyroid hormone,

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Delmas PD, Fraser M. Strong bones in later life: luxury or necessity? Bull World Health Organ 1999; 77: 416–422.
Odabaşı E, Turan M, Tekbaş F, Kutlu M. Evaluation of osteoporotic fractures in a group of Turkish women. Turkish J Med Sci 2009; 39: 21–28.
Rodriguez-Martinez MA, Garcia-Cohen EC. Role of Ca(2+) and vitamin D in the prevention and treatment of osteoporosis. Pharmacol Ther 2002; 93: 37–49.
Turhan NÖ, Bolkan F, Duvan Cİ, Ardıçoğlu Y. The effect of isoflavones on bone mass and bone remodelling markers in postmenopausal women. Turk J Med Sci 2008; 38: 145–152.
Riggs BL, Khosla S, Melton U. A unitary model for involutional osteoporosis: estrogen deficiency causes both types I and II osteoporosis in post-menopausal women and osteoporosis in post-menopausal women and contributes to bone 1055 in aging men. J Bone Miner Res 1998; 13: 763–773.
Johnston CC, Slemenda CW. Changes in skeletal tissue during the aging process. Nutr Rev 1992; 50: 385–387.
Lowe NM, Ellahi B, Bano Q, Bangash SA, Mitra SR, Zaman M. Dietary calcium intake, vitamin D status, and bone health in postmenopausal women in rural Pakistan. J Health Popul Nutr 2011; 29: 465–470.
Heaney RP. Calcium intake requirement and bone mass in the elderly. J Lab Clin Med 1982; 100: 309–312.
Nordin BE, Need AG, Morris HA, Horowitz M. New approaches to the problems of osteoporosis. Clin Orthop Relat Res 1985; 200: 181–197.
Mawer EB, Davies M. Vitamin D nutrition and bone disease in adults. Rev Endocrin Metabol Disord 2001; 2: 153–164.
Pfeifer M, Begerow B, Minne HW, Schlotthauer T, Pospeschill M, Scholz M, Lazarescu AD, Pollähne W. Vitamin D status, trunk muscle strength, body sway, falls, and fractures among 237 postmenopausal women with osteoporosis. Experiment Clin Endocrin Diabet 2001; 109: 87–92.
Ozkurt B, Ozkurt ZN, Altay M, Aktekin CN, Cağlayan O, Tabak Y. The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. Joint Diseases and Related Surgery 2009; 20: 78–84.
Bandeira F, Griz L, Dreyer P, Eufrazino C, Bandeira C, Freese E. Vitamin D deficiency: a global perspective. Arq Bras Endocrinol Metab 2006; 50: 640–646.
Reid IR, Ames R, Evans MC, Sharpe S, Gamble G, France JT, Lim TM, Cundy TF. Determinants of total body and regional one mineral density in normal postmenopausal women—a key role for fat mass. J Clin Endocrinol Metab 1992; 75: 45–51.
Sosa Henriquez M, Gomez de Tejada Romero MJ. Evidenced based medicine and drugs approved for the treatment of osteoporosis. Role of calcium and vitamin D. Rev Clin Esp 2009; 209: 25–36.
Atik OS. Osteoporotic fracture risk assessment. Joint Dis Rel Surg 2008; 19: 100.
Boonen S, Rizzoli R, Meunier PJ, Stone M, Nuki G, Syversen U, Lehtonen-Veromaa M, Lips P, Johnell O, Reginster JY. The need for clinical guidance in the use of calcium and vitamin D in the management of osteoporosis: a consensus report. Osteoporos Int 2004; 15: 511–519.
Atli T, Gullu S, Uysal AR, Erdogan G. The prevalence of vitamin D deficiency and effects of ultraviolet light on vitamin D levels in elderly Turkish population. Arch Gerontol Geriatr 2005; 40: 53–60.
Kutsal YG, Özgüçlü E, Karahan S. Effect of wearing style on vitamin D and bone mineral density in postmenopausal osteoporotic women. Turk J Osteoporosis 2011; 17: 85–88.
Kaya T, Ulutaş Ö, Çavuşoğlu AÇ, Aslanca D, Karatepe AG, Günaydın R, Karaca B. Serum levels of (25) 0H vitamin-D and hyperparathyroidism in healthy postmenopausal women. Rheumatism 2007; 22: 20–23.
Malabanan AO, Holick MF. Vitamin D and bone health in postmenopausal women. J Womens Health 2003; 12: 151–156.
Thomas MK, Lloyd-Jones DM, Thadhani RI, Shaw AC, Deraska DJ, Kitch BT, Vamvakas EC, Dick IM, Prince RL, Finkelstein JS. Hypovitaminosis D in medical inpatients. N Engl J Med 1998; 338: 777–783.
Vieth R, Ladak Y, Walfish PG. Age-related changes in the 25-hydroxylvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinol Metab 2003; 88: 185–191.
Aloia JF, Talwar SA, Pollack S, Feuerman M, Yeh JK. Optimal vitamin D status and serum parathyroid hormone concentrations in African American women. Am J Clin Nutr 2006; 84: 602–609.
Shakinba M, Tefagh S, Nafei Z. The optimal dose of vitamin D in growing girls during academic years: a randomized trial. Turk J Med Sci 2011; 41: 33–37.
Souberbielle JC, Cormier C, Kindermans C, Gao P, Cantor T, Forette F, Baulieu EE. Vitamin D status and redefining serum parathyroid hormone reference range in the elderly. J Clin Endocrinol Metab 2001; 86: 3086–3090.
Steingrimsdottir L, Gunnarsson O, Indridason O, Franzson L, Sigurdsson G. Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. JAMA 2005; 294: 2336–2341.
Yan L, Prentice A, Zhang H, Wang X, Stirling D, Golden M. Vitamin D status and parathyroid hormone concentrations in Chinese women and men from north-east of the People’s Republic of China. Eur J Clin Nutr 2000; 54: 68–72.
Gomez-Alonso C, Naves-Diaz ML, Fernandez-Martin JL, Diaz-Lopez JB, Fernandez-Coto MT, Cannata-Andia JB. Vitamin D status and secondary hyperparathyroidism: the importance of 25-hydroxyvitamin D cut-off levels. Kidney Int Suppl 2003; 85: 44–48.
Bischoff-Ferrari H, Dietrich T, Orav E, Dawson-Hughes B. Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med 2004; 116: 634–639.
Karadağ AS, Ertuğrul DT, Tutal E, Akın KO. The role of anemia and vitamin D levels in acute and chronic telogen effluvium. Turk J Med Sci 2011; 41: 827–833.
Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int 2005; 16: 713–716.