Octreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma

Öz Background/aim: Insulin-like growth factor (IGF)-I is a differentiation and growth factor. Antifibrotic action of octreotide has been reported in pulmonary fibrosis. The present study aimed to research the prophylactic and therapeutic potential of octreotide on a bleomycin (BLM)-induced experimental scleroderma model. Materials and methods: Sixty Balb/c female mice were divided into 6 groups. Daily subcutaneous BLM (100 μg) was injected for 3 weeks in groups II and III and for 6 weeks in groups V and VI. Octreotide (100 μg/kg per day) was injected subcutaneously for the first 3 weeks in group III (prophylactic) and the second 3 weeks in group VI (therapeutic). Mice in groups I, II, and III were sacrificed at the end of the third week, while mice in groups IV, V, and VI were sacrificed at the end of the sixth week. Results: Repeated BLM applications increased dermal inflammatory cell counts and dermal thickness, and led to dermal fibrosis at both the third and sixth weeks. Moreover, mRNA expressions of TGF-ß1 and IGF binding protein (IGFBP)-3 and -5 were higher in the BLMinjected sham groups. On the other hand, IGFBP-3 and -5 mRNA expressions were significantly decreased in both the prophylactic and therapeutic octreotide groups. Similarly, octreotide decreased dermal inflammatory infiltrations and dermal thickness. Conclusion: Octreotide has antifibrotic actions on experimentally induced dermal fibrosis. It can be suggested that IGF-I plays pathogenic roles, and octreotide is a candidate for research in the treatment of scleroderma.

Kaynak Göster

Bibtex @ { tbtkmedical576748, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2018}, volume = {48}, pages = {886 - 891}, doi = {}, title = {Octreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma}, key = {cite}, author = {Orhan, SİBEL OYUCU and Tektemur, AHMET and Gözel, NEVZAT and Özercan, İBRAHİM HANİFİ and Yolbaş, Servet and Yıldırım, AHMET and Önalan, EBRU and Koca, Süleyman Serdar} }
APA Orhan, S , Tektemur, A , Gözel, N , Özercan, İ , Yolbaş, S , Yıldırım, A , Önalan, E , Koca, S . (2018). Octreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma . Turkish Journal of Medical Sciences , 48 (4) , 886-891 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45702/576748
MLA Orhan, S , Tektemur, A , Gözel, N , Özercan, İ , Yolbaş, S , Yıldırım, A , Önalan, E , Koca, S . "Octreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma" . Turkish Journal of Medical Sciences 48 (2018 ): 886-891 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45702/576748>
Chicago Orhan, S , Tektemur, A , Gözel, N , Özercan, İ , Yolbaş, S , Yıldırım, A , Önalan, E , Koca, S . "Octreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma". Turkish Journal of Medical Sciences 48 (2018 ): 886-891
RIS TY - JOUR T1 - Octreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma AU - SİBEL OYUCU Orhan , AHMET Tektemur , NEVZAT Gözel , İBRAHİM HANİFİ Özercan , Servet Yolbaş , AHMET Yıldırım , EBRU Önalan , Süleyman Serdar Koca Y1 - 2018 PY - 2018 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 886 EP - 891 VL - 48 IS - 4 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Octreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma %A SİBEL OYUCU Orhan , AHMET Tektemur , NEVZAT Gözel , İBRAHİM HANİFİ Özercan , Servet Yolbaş , AHMET Yıldırım , EBRU Önalan , Süleyman Serdar Koca %T Octreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma %D 2018 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 48 %N 4 %R %U
ISNAD Orhan, SİBEL OYUCU , Tektemur, AHMET , Gözel, NEVZAT , Özercan, İBRAHİM HANİFİ , Yolbaş, Servet , Yıldırım, AHMET , Önalan, EBRU , Koca, Süleyman Serdar . "Octreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma". Turkish Journal of Medical Sciences 48 / 4 (Ağustos 2018): 886-891 .
AMA Orhan S , Tektemur A , Gözel N , Özercan İ , Yolbaş S , Yıldırım A , Önalan E , Koca S . Octreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma. Turkish Journal of Medical Sciences. 2018; 48(4): 886-891.
Vancouver Orhan S , Tektemur A , Gözel N , Özercan İ , Yolbaş S , Yıldırım A , Önalan E , Koca S . Octreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma. Turkish Journal of Medical Sciences. 2018; 48(4): 886-891.
IEEE S. Orhan , A. Tektemur , N. Gözel , İ. Özercan , S. Yolbaş , A. Yıldırım , E. Önalan ve S. Koca , "Octreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma", Turkish Journal of Medical Sciences, c. 48, sayı. 4, ss. 886-891, Ağu. 2018

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