Hand functions in systemic lupus erythematosus: a comparative study with rheumatoid arthritis patients and healthy subjects

Hand functions in systemic lupus erythematosus: a comparative study with rheumatoid arthritis patients and healthy subjects

Background/aim: Systemic lupus erythematosus (SLE) frequently affects the small joints of the hand and may result in difficulty inactivities of daily living. There are very few studies evaluating the problems encountered in the hands in patients with SLE. The aim ofthis study is to evaluate hand functions in patients with SLE and compare them with rheumatoid arthritis (RA) patients and healthysubjects.Materials and methods: A total 46 female patients meeting the SLE classification criteria were recruited. Similarly, 51 female RA patientsand 46 healthy female subjects served as the control groups. To assess the upper extremity disability level, the Disability Arm Shoulderand Hand Questionnaire (DASH) was used. Some functional performances such as hand grip and pinch strength were evaluated usinga dynamometer and the Nine Hole Peg Test (NHPT), respectively.Results: Hand functions were found to be impaired in both SLE and RA patients when compared to healthy controls. In addition,patients with SLE showed better performance in the NHPT, hand grip, and pinch strength than RA patients (P < 0.05). However, thepatient-reported disability level was similar in both patient groups (P > 0.05).Conclusion: Similar to patients with RA, hand functions are significantly impaired in patients with SLE in daily activities.

___

  • Grainne M, Lisnevskaia L, Isenberg D. Systemic lupus erythematosus and other autoimmune rheumatic diseases: challenges to treatment. Lancet 2013; 382: 809-818.
  • Fernández A, Quintana G, Matteson EL, Restrepo JF, Rondón F, Sánchez Á, Iglesias A. Lupus arthropathy: historical evolution from deforming arthritis to rhupus. Clin Rheumatol 2004; 23: 523-526.
  • World Health Organization. International Classification of Functioning, Disability and Health: ICF. Geneva, Switzerland: World Health Organization; 2001. 4. Dray GJ. The hand in systemic lupus erythematosus. Hand Clinics 1989; 5: 145-155.
  • Birgitha A, Burckhardt CS, Segesten K. Quality of life of women with systemic lupus erythematosus or rheumatoid arthritis: domains of importance and dissatisfaction. Qual Life Res 1999; 8: 411-416.
  • Hall AM, Copsey B, Williams M, Srikesavan C, Lamb SE. The mediating effect of changes in hand impairments on hand function in patients with rheumatoid arthritis: exploring the mechanisms of an effective exercise programme. Arthritis Care Res 2017; 69: 982-988.
  • Dhanhani AMA, Gignac MA, Su J, Fortin PR. Work disability in systemic lupus erythematosus. Arthritis Care Res 2009; 61: 378-385.
  • Drenkard C, Bao G, Dennis G, Kan HJ, Jhingran PM, Molta CT, Lim SS. Burden of systemic lupus erythematosus on employment and work productivity: data from a large cohort in the southeastern United States. Arthritis Care Res 2014; 66: 878-887.
  • Johnsson PM, Sandqvist G, Bengtsson A, Nived O. Hand function and performance of daily activities in systemic lupus erythematosus. Arthritis Care Res 2008; 59: 1432-1438.
  • Johnsson PM, Sandqvist G, Nilsson JÅ, Bengtsson AA, Sturfelt G, Nived O. Hand function and performance of daily activities in systemic lupus erythematosus: a clinical study. Lupus 2015;24: 827-834.
  • Petri M, Orbai AM, Alarcón GS, Merrill JT, Fortin PR, Bruce IN, Isenberg D, Wallace DJ, Nived O, Sturfelt G et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012; 64: 2677-2686.
  • Neogi T, Aletaha D, Silman AJ, Naden RL, Felson DT, Aggarwal R, Bingham CO 3rd, Birnbaum NS, Burmester GR, Bykerk VP et al. The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: Phase 2 methodological report. Arthritis Rheum 2010; 62: 2582-2591.
  • Mathiowetz V, Weber K, Volland G, Kashman N. Reliability and validity of grip and pinch strength evaluations. J Hand Surg 1984; 9: 222-226.
  • Grice KO, Vogel KA, Le V, Mitchell A, Muniz S, Vollmer MA. Adult norms for a commercially available Nine Hole Peg Test for finger dexterity. Am J Occup Ther 2003; 57: 570-573.
  • Düger T, Yakut E, Öksüz Ç, Yörükan S, Bilgütay BS, Ayhan Ç. Kol, omuz ve el sorunları (Disabilities of the Arm, Shoulder and Hand-DASH) anketi Türkçe uyarlamasının güvenirliği ve geçerliği. Türk Fizyoterapi ve Rehabilitasyon Dergisi 2006; 17: 99-107 (in Turkish).
  • Bilberg A, Bremell T, Mannerkorpi K. Disability of the Arm, Shoulder and Hand questionnaire in Swedish patients with rheumatoid arthritis: a validity study. J Rehabil Med 2012; 44: 7-11.
  • Aisen AM, Gabrielsen TO, McCune WJ. MR imaging of systemic lupus erythematosus involving the brain. Am J Neuroradiol 1985; 6: 197-201.
  • Piga M, Gabba A, Congia M, Figus F, Cauli A, Mathieu A. Predictors of musculoskeletal flares and Jaccoud’s arthropathy in patients with systemic lupus erythematosus: a 5-year prospective study. Semin Arthritis Rheum 2016; 46: 217-224.
  • Mancuso CA, Perna M, Sargent AB, Salmon JE. Perceptions and measurements of physical activity in patients with systemic lupus erythematosus. Lupus 2011; 20: 231-242.
  • Jakes RW, Bae SC, Louthrenoo W, Mok CC, Navarra SV, Kwon N. Systematic review of the epidemiology of systemic lupus erythematosus in the Asia-Pacific region: prevalence, incidence, clinical features, and mortality. Arthritis Care Res (Hoboken) 2012; 64: 159-168.