Neuropharmacological effects of methanolic extracts of Rubus fruticosus L.

To investigate methanol extracts of various parts of Rubus fruticosus L. (Rosaceae) for various neuropharmacological activities, such as anxiolytic, muscle relaxant, antidepressant, and sedative activities. Materials and methods: The extracts were administered to albino mice orally at doses of 100, 300, and 500 mg/kg. The antidepressant activity was determined by using the forced swimming test, while line crossing in a special box was used for assessment of locomotor activity. Results: All extracts were found to be anxiolytic in nature, while no muscle relaxing activity or sedative effect was observed. The order of central nervous system (CNS) depressant effect for various parts of R. fruticosus was fruit > root > leaves > stem. Conclusion: Our results indicate that methanolic extract of various parts of R. fruticosus possess anxiolytic and CNS depressant effects but do not possess significant sedative or muscle relaxing potential.

Neuropharmacological effects of methanolic extracts of Rubus fruticosus L.

To investigate methanol extracts of various parts of Rubus fruticosus L. (Rosaceae) for various neuropharmacological activities, such as anxiolytic, muscle relaxant, antidepressant, and sedative activities. Materials and methods: The extracts were administered to albino mice orally at doses of 100, 300, and 500 mg/kg. The antidepressant activity was determined by using the forced swimming test, while line crossing in a special box was used for assessment of locomotor activity. Results: All extracts were found to be anxiolytic in nature, while no muscle relaxing activity or sedative effect was observed. The order of central nervous system (CNS) depressant effect for various parts of R. fruticosus was fruit > root > leaves > stem. Conclusion: Our results indicate that methanolic extract of various parts of R. fruticosus possess anxiolytic and CNS depressant effects but do not possess significant sedative or muscle relaxing potential.

___

  • Zabihullah Q, Rashid A, Akhtar N. Ethnobotanical survey of Kot Manzary Baba valley, Malakand Agency, Pakistan. Pak J Plant Sci 2006; 12: 115–122.
  • Sher H. Ethnoecological evaluation of some medicinal and aromatic plants of Kot Malakand Agency, Pakistan. Sci Res Essays 2011; 6: 2164–2173.
  • Ajaib M, Khan Z, Khan N, Wahab M. Ethnobotanical studies on useful shrubs of district Kotli, Azad Jammu and Kashmir, Pakistan. Pak J Bot 2010; 42: 1407–1415.
  • Ahmad S, Ali A, Beg H, Dasti AA, Shinwari ZK. Ethnobotanical studies on some medicinal plants of Booni Valley, District Chitral, and Pakistan. Pak J Weed Sci 2006; 12: 183–190.
  • Jan G, Khan MA, Gul F. Ethnomedicinal plants used against diarrhea and dysentery in Dir Kohistan valley (NWFP), Pakistan. Ethnobot Leaf 2008; 1: 84–85.
  • Shah GM, Khan MA. Common medicinal folk recipes of Siran valley, Mansehra, Pakistan. Ethnobot Leaf 2006; 1: 5–6.
  • Humayun M. Medicinal folk recipes, ethnobotanical studies of some useful shrubs and trees of District Buner NWFP Pakistan. J Ethnobot Leaf 2003; 7: 31–43.
  • Bown D. Encyclopaedia of Herbs and Their Uses. London, UK: Dorling Kindersley; 1995.
  • Phillips R, Foy N. Herbs. London: Pan Books Limited; 1990.
  • Riaz M, Ahmad M, Rahman N. Antimicrobial screening of fruit, leaves, root and stem of Rubus fruticosus L. J Med Plants Res 2011; 5: 5920–5924.
  • Chevallier A. The encyclopedia of medicinal plants. London, UK: Dorling Kindersley; 1996.
  • Chiej R. Encyclopaedia of Medicinal Plants. London, UK: MacDonald and Company Limited; 1984.
  • Ozarowski A, Jaroniewski W. Medicinal Plants and Their Practical Application. Warsaw, Poland: Institute Wyd Zw Zawod; 1989.
  • Borkowski B, Lutomski J, Skrzydlewska E, Zygmunt B. Rosliny Lecznicze w Fitoterapii. Poznan, Poland: Institute Roślin I Przetworów Ziel; 1994.
  • Simoni DE, Guarrera PM. Indagine etnobotanica nella Provincia di Teramo. Quaderni Botanica Ambientale Applicat 1994; 15: 3–10.
  • Enache G, Iancu M. Composition for treating digestive disorders of calves and piglets. Rom Ro 1981; 75: 752.
  • Marquina MA, Corao GM, Araujo L, Buitrago D, Sosa M. Hyaluronidase inhibitory activity form the polyphenols in the fruit of blackberry (Rubus fruticosus B.). Fitoterapia 2002; 73: 727–729.
  • Corao GM, Marquina M, Buitrago D, Araujo L, Sosa M, Araujo L, Buitrago YD.“Actividad antiviral de la mora Antiviral activity of blackberries( Rubus fruticosus B.) mediante electroforesis en geles”. (Rubus fruticosus B.) gel electrophoresis.Revista Latinoamericana de Química, Rev Lat Am Quím 30(1):17-23, 2002002; 30: 17–23.
  • Kazumasa S, Yuichi M, Kenji O, Susumu S. Deodorants for allyl methyl monosulfide and foods beverages and deodorant composition containing them. Jpn Kokai Tokkyo Koho Jp 2003; 335: 647.
  • Shepherd T, Robertson GW, Griffiths DW, Birch ANE. Epicuticular wax composition in relation to aphid infestation and resistance in red raspberry (Rubus idaeus L.). Phytochem 1999; 52: 1239–1254.
  • Gupta R, Al-Shafi S, Layden K, Haslam E. The metabolism of gallic acid and hexahydroxydiphenic acid in plants. Part 2. Esters of (S)-hexahydroxydiphenic acid with D-glucopyranose ( 4 C 1 ). J Chem Soc Perkin Trans 1982; 1: 2525–2534.
  • Ogawa K, Sakakibara H, Iwata R, Ishii T, Sato T, Goda T, Shimoi K, Kumazawa S. Anthocyanin composition and antioxidant activity of the Crowberry (Empetrum nigrum) and other berries. J Agric Food Chem 2008; 56: 4457–4462.
  • Mazur WM, Uehara M, Wahala K, Adlercreutz H. Phytooestrogen content of berries and plasma concentrations and urinary excretion of enterolactone after a single strawberrymeal in human subjects. Brit J Nutr 2000; 83: 381–387.
  • Hoed VV, Clercq ND, Echim C, Andjelkovic M, Leber E, Dewettinck K, Verhé R. Berry seeds: a source of specialty oils with high content of bioactives and nutritional value. J Food Lipids 2009; 16: 33–49.
  • Gudej J, Tomczyk M. Determination of flavonoids, tannins and ellagic acid in leaves from Rubus L. species. Arch Pharm Res 2004; 27: 1114–1119.
  • Marinova D, Ribarova F. HPLC determination of carotenoids in Bulgarian berries. J Food Comp Anal 2007; 20: 370–374.
  • Wyttenbach A, Furrer V, Schleppi P, Tobler L. Rare earth elements in soil and in soil-grown plants. Plant and Soil 1998; 199: 267–273.
  • Yadav AV, Kawale LA, Nade VS. Effect of Morus alba L. (mulberry) leaves on anxiety in mice. Ind J Pharmacol 2008;40: 32–
  • Zia-Ul-Haq M, Stanković M, Rizwan K, DeFeo V. Grewia asiatica L., a food plant with multiple uses. Molecules 2013; 18: 2663–2682.
  • Zia-Ul-Haq M, Ahmad S, Amarowicz R, DeFeo V. Antioxidant activity of the extracts of some cowpea (Vigna unguiculata (L.) Walp.) cultivars commonly consumed in Pakistan. Molecules 2013; 18: 2005–2017.
  • Zia-Ul-Haq M, Cavar S, Qayum M, Khan I, Ahmad S. Compositional studies and antioxidant potential of Acacia leucophloea Roxb. Acta Bot Croatica 2013; 72: 133–144.
  • Kennett GA, Dickinson SL and Curzon G. Central serotonergic responses and behavioral adaptation to repeated immobilization: the effect of corticosterone synthesis inhibitor metyrapone. Eur J Pharmacol 1985; 119: 143–152.
  • Kennett GA, Dickinson SL, Curzon G. Enhancement of some 5-HT depressant behavioral responses following repeated immobilization in rats. Brain Res 1985; 330: 253–263.
  • Turner RA, Hebborn P. Screening Methods in Pharmacology. New York, NY, USA: Academic Press; 1965.
  • Sanchez-Mateo CC, Prado B, Rabanal RM. Antidepressant effects of the methanol extract of several Hypericum species from the Canary Islands. J Ethnopharmacol 2002; 79: 119–127.
  • Kasture VS, Deshmukh VK, Chopde CT. Anxiolytic and anticonvulsive activity of Sesbania grandiflora leaves in experimental animals. Phytother Res 2002; 16: 455–460.
  • Debprasad C, Arunachalam G, Subhash C, Mandal RB, Mandal AB. CNS activities of the methanol extract of Mallotus peltatus (Geist) Muell Arg. leaf: an ethnomedicine of Onge. J Ethnopharmacol 2003; 85: 99–105.
  • Crestani F, Martin JR, Mohler H, Rudolph U. Mechanism of action of the hypnotic zolpidem in vivo. Brit J Pharmacol 2000; 131: 1251–1254.
  • Sakina MR, Dandiya PC. A psychopharmacological profile of Centella asiatica extract. Fitoterapia 1990; 61: 291–296.
  • Emamghoreishi M, Khasaki M, Aazam MF. Coriandrum sativum: evaluation of its anxiolytic effect in the elevated plusmaze. J Ethnopharmacol 2005; 96: 365–370.
  • Randolph RK, Roh-Schmidt H. Cytokine modulators and related methods of use. US Patent 2007; 11: 508343.
  • Subarnas A, Tadano T, Nakahata N, Arai Y, Kinemuchi H, Oshima Y, Kisara K, Ohizumi Y A possible mechanism of antidepressant activity of beta-amyrin palmitate isolated from Lobelia inflata leaves in the forced swimming test. Life Sci 1993; 52: 289–296.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Refeeding hypophosphatemia: a potentially fatal danger in the intensive care unit*

Kürşat GÜNDOĞAN, Murat SUNGUR, Süleyman BALDANE, Ramazan COŞKUN, Muhammet GÜVEN

Diastolic function of the right ventricle is impaired in experimental type 2 diabetic rat models

Ya MIAO, Wei ZHANG, Yuan ZHONG, Ming ZHONG, Xiao MA

Comparison of cutaneous mastocytosis with onset in children and adults

Serap GÜNEŞ BİLGİLİ, Ayşe Serap KARADAĞ, Zennure TAKCI, Ömer ÇALKA, Mustafa KÖSEM

The McGrath series 5 video laryngoscope versus the Macintosh laryngoscope: a randomized trial in obstetric patients

Semih ARICI, Serkan KARAMAN, Serkan DOĞRU, Tuğba KARAMAN

Leiomyoma of the esophagus: open versus thoracoscopic enucleation

Sedat ZİYADE, Hüseyin KADIOĞLU, Şenel YEDİYILDIZ, Nur BÜYÜKPINARBAŞILI, Ömer SOYSAL

Neuropharmacological effects of methanolic extracts of Rubus fruticosus L.

Muhammad RIAZ, Muhammad ZIA-UL-HAQ, Najm UR-RAHMAN, Mansoor AHMAD

Effects of intraabdominal pressure on mean platelet volume during laparoscopic cholecystectomy

Rüçhan Bahadır CELEP, Şahin KAHRAMANCA, Mustafa ÖZSOY, Cem AZILI, Süleyman ÇETİNKÜNAR, Ahmet Oğuz HASDEMİR, Hakan GÜZEL, Gülay ÖZGEHAN, İbrahim ÇOLHAN, Tevfik Hadi KÜÇÜKPINAR

An unusual case of sclerosing angiomatoid nodular transformation: radiological and histopathological analyses

Melike Ruşen METİN, Şehnaz EVRİMLER, Nurdan ÇAY, Hüseyin ÇETİN

Prevalence of blaIMP and blaVIM gene carriage in metallo-β lactamase-producing burn isolates of Pseudomonas aeruginosa in Tehran

Fereshteh EFTEKHAR, Fatemeh SALIMI

Prevalence of blAbstractP and blaVIM gene carriage in metallo-b-lactamase-producing burn isolates of Pseudomonas aeruginosa in Tehran

Fatemeh SALIMI, Fereshteh EFTEKHAR