Megadose Methylprednisolone for Childhood Idiopathic Trombocytopenic Purpura (ITP)

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder. Decreased platelet survival is the main pathogenesis, which is related to platelet antibodies (APA). The levels of these antibodies are correlated with relapse and remission which was shown for the first time by our group. Although APA levels decrease in remission they do not disappear as we have shown. Among the several appraches to ITP treatment, oral megadose methylprednisolone is found to be the cheapest and most effective one. For oral MDMP treatment, admission of the patients is not required and there is some evidence that chronic ITP could be prevented by this approach.

Anahtar Kelimeler:

Mega dose methylprednisolone, idiopathic trombocytopenic purpura

Megadose Methylprednisolone for Childhood Idiopathic Trombocytopenic Purpura (ITP)

Keywords:

Mega dose methylprednisolone, idiopathic trombocytopenic purpura,

PDF

___

Branehög I.Platelet kinetics in idiopathic thrombcoytopenic purpura (ITP) before and at different times after splenectomy. Br J Haematol 29:413-418,1975.
Harrington WJ, Minnich V, Hollings wath JW et al. Demonstration of a thrombocytopenia factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med 38:1-9,1951.
Özsoylu fi, Irken G, Karabent A. High-dose intravenous methylprednisolone for acute childhood idiopathic thrombocytopenic purpura. Eur J Haematol 42:431-435, 1989.
Schwartz AD. A method for demonstrating shortened platelet survival recovery from asprin effect. J Pediatr 84:350, 1974.
McClure PD. Idiopathic thromboyctopenic purpura in children. Should corticosteroid be given. Am J dis Child 131:357- 359,1977.
Zuelzer WW, Lusher JM. Childhood idiopathic thrombocytopenic purpura. To treat or not to treat. Am J Dis Child 131:360- 362,1977.
Imbach P, Wagner HP, Berithold W et al. Intravenous immunoglobulin versus corticosteroid in acute immune thrombcytopenic purpura in childhood. Lancet 2:464-468,1985.
Ryan ME, Webster ML: Adverse effects of intravenous immunglobulin therapy. Clin Pediatr 35: 23-28,1996.
Brecher G, Cronkite EP. Morphology and enumeration of human blood platelets. J Appl Physiol 3:365-377,1951.
Özsoylu fi, Ertürk G. Oral megadose methylprednisolone for childhood acute idiopathic thrombocytopenic purpura. Blood 77:1856-1857,1991
Özsoylu fi, Saylı T, Ertürk G. Oral megadose methylprednisolone versus intravenous immunglobulin for acute childhood acute idiopathic thrombocytopenic purpura. Pediatr Hematol Oncol 10:317-321,1993.
Özsoylu fi. Bolus methylprednisolone therapy in chronic idiopathic thrombocytopenic purpura in children. Acta Haematol 72:359,1984.
Özsoylu fi. High dose intravenous methylprednisolone for chronic idiopathic thrombocytopenic purpura. Acta Haematol 81:112- 113,1989.
Akoğlu T, Paydafl ?, Bayık M et al. Megadose methylprednisolone pulse therapy in adult idiopathic thrombocytopenic purpura in adults. Lancet 337:56,1991.
Manoharan A. Treatment of refractory idiopathic thrombocytopenic purpura in adults. Br J Haematol 79:143, 1991.
Özsoylu fi. Nose drops and the common cold. Eur J Pediatr 144:294,1985.
Bernini JC, Carillo JM, Buchanon GR. High-dose intravenous methylprednisolone therapy for patient with Diamond –Blackfan anemia refractory to conventional doses of prednisone. J Pediatr 127:654-659, 1995.
Öztürk G, Özsoylu fi. Megadose methylprednisolone for a corticosteroid induced diabetic patient with aplastic anemia. Turk J Med Sciences 21:74,1994.
Özsoylu fi, Coflkun T, Minassazi S. High dose intravenous glucocorticoid in the treatment of childhood acquired aplastic anemia. Scand J Haematol 33:309-316,1984.
Özsoylu fi. High dose intravenous cortcosteroids treatment for patients with Diamond-Blackfaan syndrome resistant or refracter to conventional treatment. Am J Pediat Hematol/Oncol 10:210- 217,1988.
Özsoylu fi. High dose intravenous methylprednisolone (HIVMP) in hematologic disorders. Hematology Reviews 4:197-207, 1990.
fiaylı TR, Özsoylu fi. Serum erythropoietin and granulocyte macrophage colony stimulating factor levels with megadose methylprednisolone. Turk J Pediatr 38:491-495,1996.
Tuncer AM, Özsoylu fi, Ersoy F et al. The effects of glucocorticoid on lymphocyte numbers. Immunology Today 12:207, 1991.