Hatice Elif PEŞTERELİ, Okan ERDOĞAN, Bahar KILIÇARSLAN, Taner ÇOLAK, Şeyda KARAVELİ, Mustafa AKAYDIN, Evren TERCAN

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Immunohistochemical Expression of C-Erb-B2, Steroid Receptors and Cathepsin-D in Breast Carcinomas: A Clinicopathologic Trial

Aim: We investigated the role of c-erb-B2, hormone receptors and cathepsin D in breast carcinoma progression and their correlation with each other. Methods: Forty-six breast carcinoma patients, operated on in the deparment of surgery and diagnosed in the pathology department, were classified according to their histopathological characteristics; the results of immunostaining with estrogen and progesterone receptors, c-erb-B2 and cathepsin-D were correlated with the stage and the disease-free survival of the patients. Results: Nuclear positivity was observed in 23 (50 %) cases for estrogen receptor and in 16 (34.8 %) cases for progesterone receptor. There was membranous staining with c-erb-B2 in 37 (80.4 %) cases and cytoplasmic staining with cathepsin-D in 44 (95.6 %) cases. Cathepsin-D positivity was significantly related to the axillary lymph node metastases (p

Anahtar Kelimeler:

Breast carcioma, cathepsin-D, c-erb-B2

Immunohistochemical Expression of C-Erb-B2, Steroid Receptors and Cathepsin-D in Breast Carcinomas: A Clinicopathologic Trial

Aim: We investigated the role of c-erb-B2, hormone receptors and cathepsin D in breast carcinoma progression and their correlation with each other. Methods: Forty-six breast carcinoma patients, operated on in the deparment of surgery and diagnosed in the pathology department, were classified according to their histopathological characteristics; the results of immunostaining with estrogen and progesterone receptors, c-erb-B2 and cathepsin-D were correlated with the stage and the disease-free survival of the patients. Results: Nuclear positivity was observed in 23 (50 %) cases for estrogen receptor and in 16 (34.8 %) cases for progesterone receptor. There was membranous staining with c-erb-B2 in 37 (80.4 %) cases and cytoplasmic staining with cathepsin-D in 44 (95.6 %) cases. Cathepsin-D positivity was significantly related to the axillary lymph node metastases (p

Keywords:

Breast carcioma, cathepsin-D, c-erb-B2,

Turkish Journal of Medical Sciences-Cover

ISSN: 1300-0144
Yayın Aralığı: 6
Yayıncı: TÜBİTAK

Arşiv

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