Ülver DERİCİ, Burak KÖPRÜ, S. Müge DEĞER, Giray ERGİN, Turgay ARINSOY

High neutrophil-to-lymphocyte ratio predicts acute allograft rejection in kidney transplantation: a retrospective study

Background/aim: Our research focused on the identification of easily available and sensitive markers for early prediction of acutekidney allograft rejection (AR). We aimed to investigate the association between neutrophil-to-lymphocyte ratio (NLR) and AR inkidney transplant patients.Materials and methods: The medical records of 51 kidney transplant patients [12 female/39 male; median age of 32 (IQR: 24–44) years]were evaluated retrospectively. We considered a cut-off value of >2.5 as high NLR.Results: A total of 22 biopsy-proven AR patients and 29 controls were evaluated. The AR group had a higher NLR compared to thecontrols (P < 0.001). NLR levels over 2.5 [95% CI: 54.88 (9.96–302.3), P < 0.001] were significantly associated with AR in univariateanalysis. The NLR levels were the only significant factor associated with AR in multivariate models, in model 1 (adjusted by age andsex) [95% CI: 114 (11.1–1175), P < 0.001], and in model 2 (adjusted by steroid dosage, uric acid, and NLR) [95% CI: 4.60 (1.59–29.3),P = 0.004].Conclusion: Our data showed that higher NLR values (>2.5) are associated with AR in kidney transplant patients, leading to theconclusion that NLR might be an easily available and useful marker option for detection of AR in this patient population.

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