İvana DAMNJANOVIC, Dusanka KITIC, Nikola STEFANOVIC, Snezana ZLATKOVIC-GUBERINIC, Aleksandra CATIC-DJORDJEVIC, Radmila VELICKOVIC-RADOVANOVIC

Herbal self-medication use in patients with diabetes mellitus type 2

Background/aim: A considerable number of patients suffering from diabetes mellitus (DM) turn to self-medication using medicinal plants, preparations, and medicine. The aim of this study was to investigate self-medication using medicinal plants and the potential influence of health care professionals' advice or media information regarding the use of herbal dietary supplements with hypoglycemic effect in a population of patients with type 2 DM. Materials and methods: This research, in the form of an analytic cross-sectional study, was conducted in 6 pharmacies in the territory of Nis, Serbia, during October 2013. The criterion set for the study was to include patients diagnosed with type 2 diabetes who used pharmacotherapy in addition to herbal supplements. Results: Surveyed women showed a statistically significant difference in the frequency of using herbal supplements compared to men (P < 0.001). More frequent symptoms of hypoglycemia were reported in the group of diabetic respondents who used herbal dietary supplements (P < 0.05). The media was most responsible for influencing decisions about self-medication that included the use of herbal dietary supplements. Conclusion: The role of health professionals is indispensable and very important, especially when the media is a potential cause of seeking self-medication.

Anahtar Kelimeler:

Herbal self-medication, diabetes, hypoglycemia, professionals? advice

Herbal self-medication use in patients with diabetes mellitus type 2

Keywords:

Herbal self-medication, diabetes, hypoglycemia, professionals? advice,

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Alwan A, editor. Global Status Report on Noncommunicable Diseases 2010. Geneva, Switzerland: World Health Organiza- tion; 2011.
Martins AP, Miranda Ada C, Mendes Z, Soares MA, Ferreira P, Nogueira A. Self-medication in a Portuguese urban popula- tion: a prevalence study. Pharmacoepidemiol Drug Saf 2002; 11: 409–414.
Walker RJ, Gebregziabher M, Martin-Harris B, Egede LE. Quantifying direct effects of social determinants of health on glycemic control in adults with type 2 diabetes. Diabetes Technol Ther 2015; 17: 80–87.
Birdee G, Yeh G. Complementary and alternative medicine therapies for diabetes: a clinical review. Clinical Diabetes 2010, 28: 147–155.
Shojaii A, Goushegir A, Dabaghian FH, Abdollahi M, Fallah Huseini H. Herbs and herbal preparations for glycemic con- trol in diabetes mellitus (a systematic review). J Med Plants Res 2011; 5: 3846–3855.
Corrêa da Silva MG, Soares MC, Muccillo-Baisch AL. Self- medication in university students from the city of Rio Grande, Brazil. BMC Public Health 2012; 12: 339.
Watal G, Dhar P, Srivastava SK, Sharma B. Herbal medicine as an alternative medicine for treating diabetes: the global burden. Evid Based Complement Alternat Med 2014; 2014: 596071.
Rotman-Pikielny P, Ness-Abramof R, Charach G, Roitman A, Zissin R, Levy Y. Efficacy and safety of the dietary supple- ment DBCare® in patients with type 2 diabetes mellitus and inadequate glycemic control. J Am Coll Nutr 2014; 33: 55–62.
Lee T, Dugoua JJ. Nutritional supplements and their effect on glucose control. Curr Diab Rep 2011; 11: 142–148.
Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr 2013; 64: 682–686.
Mozaffari-Khosravi H, Talaei B, Jalali BA, Najarzadeh A, Mo- zayan MR. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement Ther Med 2014; 22: 9–16.
Singh R, Kaur N, Kishore L, Gupta GK. Management of dia- betic complications: a chemical constituents based approach. J Ethnopharmacol 2013; 150: 51–70.
Balamurugan E, Ganesh K. Prevalence and pattern of self med- ication use in coastal regions of South India. BJMP 2011; 4: 428.
Ayele K, Tesfa B, Abebe L, Tilahun T, Girma E. Self care behav- ior among patients with diabetes in Harari, Eastern Ethiopia: the health belief model perspective. PLoS One 2012; 7: e35515.
Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA. Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. JAMA 2002; 287: 337–344.
Al-Asadi J, Salih N. Herbal remedies use among diabetic pa- tients in Nassyria, Iraq. Middle East Journal of Family Medi- cine 2012; 10: 40–46.
Alavi NM, Alami L, Taefi S, Gharabagh GS. Factor analysis of self-treatment in diabetes mellitus: a cross-sectional study. BMC Public Health 2011; 11: 761.
Egede LE, Ye X, Zheng D, Silverstein MD. The prevalence and pattern of complementary and alternative medicine use in in- dividuals with diabetes. Diabetes Care 2002; 25: 324–329.
Goh LY, Vitry IA, Semple SJ, Esterman A, Luszcz MA. Self- medication with over-the-counter drugs and complementary medications in South Australia’s elderly population. BMC Complement Altern Med 2009; 9: 42.
Pereira CM, Alves VF, Gasparetto PF, Carneiro DS, Ferreira Valoz FE. Self-medication in health students from two Brazil- ian universities. RSBO 2012; 9: 361–367.
Hui H, Tang G, Go VL. Hypoglycemic herbs and their action mechanisms. Chin Med 2009; 4: 11.
Baby J, Jini D. Insight into the hypoglycemic effect of tradition- al Indian herbs used in treatment of diabetes. Res J Med Plant 2011; 5: 352–376.
Kim K, Kim HY. Korean red ginseng stimulates insulin release from isolated rat pancreatic islets. J Ethnopharmacol 2008; 120: 190–195.
Kim HY, Kang KS, Yamabe N, Nagai R, Yokozawa T. Protec- tive effect of heat-processed American ginseng against diabetic renal damage in rats. J Agric Food Chem 2007; 55: 8491–8497.
Phil RA, Khan RA, Ashraf I. Effects of garlic on blood glucose levels and HbA1c in patients with type 2 diabetes mellitus. J Med Plant Res 2011; 5: 2922–2928.
Ashraf R, Khan RA, Ashraf I. Garlic (Allium sativum) supple- mentation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Pak J Pharm Sci 2011; 24: 565–570.
Ackermann RT, Mulrow CD, Ramirez G, Gardner CD, Mor- bidoni L, Lawrence VA. Garlic shows promise for improving some cardiovascular risk factors. Arch Intern Med 2001; 161: 813–824.
Mittal P, Juyal V. Drug-dietary interaction potential of garlic on glimepiride treated type 2 diabetic Wistar rats. Journal of Diabetology 2012; 3: 2.
Russo E, Scicchitano F, Whalley BJ, Mazzitello C, Ciriaco M, Esposito S, Patanè M, Upton R, Pugliese M, Chimirri S et al. Hypericum perforatum: pharmacokinetic, mechanism of ac- tion, tolerability, and clinical drug-drug interactions. Phyto- ther Res 2014; 28: 643–655.
Husain GM, Singh PN, Vikas K. Anti-diabetic activity of Indi- an Hypericum perforatum L. on alloxan-induced diabetic rats. Pharmacologyonline 2008; 3: 889–894.
Xu H, Williams KM, Liauw WS, Murray M, Day RO, McLach- lan AJ. Effects of St John’s wort and CYP2C9 genotype on the pharmacokinetics and pharmacodynamics of gliclazide. Br J Pharmacol 2008; 153: 1579–1586.
Fabian E, Töscher S, Elmadfa I, Pieber TR. Use of complemen- tary and alternative medicine supplements in patients with dia- betes mellitus. Ann Nutr Metab 2011; 58: 101–108.
Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stich- tenoth DO, Hahn A. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest 2006; 36: 340–344.
Campbell PA. Diabetes and dietary supplements. Clinical Dia- betes 2010; 28: 35–39.
Fasinu PS, Bouic PJ, Rosenkranz B. An overview of the evi- dence and mechanisms of herb–drug interactions. Front Phar- macol 2012; 3: 69.
Stull AJ, Cash KC, Johnson WD, Champagne CM, Cefalu WT. Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women. J Nutr 2010; 140: 1764– 1768.
Fakeye TO, Adisa R, Showande SJ. Attitude and opinion of Nigerian community pharmacists to self medication practic- es. African Journal of Pharmacy and Pharmacology 2012; 6: 1147–1152.
Silva IM, Catrib AM, de Matos VC, Gondim AP. Self-medi- cation in adolescence: a challenge to health education. Cien Saude Colet 2011; 16: 1651–1660.