Mustafa TURAN, Ersin ODABAŞI, Faruk TEKBAŞ, Mustafa KUTLU

Evaluation of Osteoporotic Fractures in a Group of Turkish Women

Aims: The frequency of osteoporotic fractures varies from one country to another. Epidemiologic data related to osteoporotic fractures is limited in Turkey. In this study, we aimed to explore the frequency of osteoporotic fractures in osteoporotic women on the basis of our outpatient clinic data. Additionally, we aimed to define the relationship between osteoporotic fractures and age, menopause status, bone mineral density (BMD), and body mass index (BMI). Materials and Methods: This is a retrospective chart review of 934 osteoporotic women, older than 50 years of age, seen from March 1998 through July 2005 at a musculoskeletal disease outpatient clinic of a tertiary-care center. The data related to osteoporotic bone fractures and the relation with age, menopause status, BMD (spine and femur neck), and BMI were evaluated. Results: Osteoporotic fractures were observed in 194 patients (20.8%). Vertebral fractures were the most common form of osteoporotic fracture in our patient group (107 patients). The fracture rate seems to be increased with age and menopausal state; however, such a relationship was significant only in vertebral and hip fractures. There was no significant difference in terms of BMI between the patients with or without any fractures. Conclusions: Osteoporotic fracture frequency in our study group was found to be relatively low as compared to the previous reports. It can be claimed that tendency towards osteoporotic fracture is relatively low in our study population.

Anahtar Kelimeler:

Osteoporosis, fracture, hip, vertebrae, Turkish

Evaluation of Osteoporotic Fractures in a Group of Turkish Women

Keywords:

Osteoporosis, fracture, hip, vertebrae, Turkish,

PDF

___

Consensus Development Conference - Prophylaxis and treatment of osteoporosis. Osteoporos Int 1991; 1: 114-17. 2. Kutsal YG, Atalay A, Arslan S, Başaran A, Cantürk F, Cindaş A et al. Awareness of osteoporotic patients. Osteoporos Int 2005; 16: 128-33. Kanis JA, Delmas PD, Burckhardt P, Cooper C, Togerson D. Guidelines for diagnosis and management of osteoporosis. The European Foundation for Osteoporosis and Bone Disease. Osteoporos Int 1997; 7: 390-406. 4.
Takahashi M, Kushida K, Naitou K. The degree of osteoporosis in
patients with vertebral fracture and patients with hip fracture:
relationship to incidence of vertebral fracture. J Bone Miner
Metab 1999; 17: 187-94.
Johnell O, Kanis J. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 2006; 17: 1726-33.
Johnell O, Kanis J. Epidemiology of osteoporotic fractures.
Osteoporos Int 2005; 6: S3-7. 7. Maclaughlin EJ, Sleeper RB, McNatty D, Raehl CL. Management of age-related osteoporosis and prevention of associated fractures. Ther Clin Risk Manag 2006; 3: 281-95.
Dontas IA, Yiannakopoulos CK. Risk factors and prevention of osteoporosis-related fractures. J Musculoskelet Neuronal Interact 2007; 3: 268-72. 9. Briggs AM, Greig AM, Wark JD. The vertebral fracture cascade in osteoporosis: a review of aetiopathogenesis. Osteoporos Int 2007; 5: 575-84.
Falch J, Aho H, Berglund K, Duppe H, Finsen V, Hangstrom I et al. Hip fractures in Nordic cities: difference in incidence. Ann Chir Gynaecol 1995; 84: 286-90.
Hagino H, Yamamoto K, Teshima R, Kishimoto H, Kuranobu K, Nakamura T. The incidence of fractures of the proximal femur and distal radius in Tottori Prefecture Japan. Arch Orthop Trauma Surg 1989; 109: 43-4.
Yan L, Zhou B, Prentice A, Wang X, Golden MH. Epidemiological study of hip fracture in Shenyang, People’s Republic China. Bone 1999; 24: 151-5.
Memon A, Pospula W, Tantawy A, Abdul-Ghafar S, Suresh A, Al- Rowaih A. Incidence of hip fracture in Kuwait. Int J Epidemiol 1998; 27: 860-5.
Solomon L. Osteoporosis and fracture of femoral neck in the South African Bantu. J Bone Joint Surg Br 1968; 50: 2-13.
Papaioannou A, Watts NB, Kendler DL, Yuen CK, Adachi JD, Ferko N. Diagnosis and management of vertebral fractures in elderly adults. Am J Med 2002; 113: 220-8.
Genant HK, Wu CY, van Kuijk C, Nevitt MC. Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 1993; 8: 1137-48.
Grigoryan M, Guermazi A, Roemer FW, Delmas PD, Genant HK. Recognizing and reporting osteoporotic vertebral fractures. Eur Spine J 2003; 12: S104-12.
Johnell O, Gullberg B, Kanis JA, Allander E, Elffors L, Dequeker J et al. Risk factors for hip fracture in European women: the MEDOS Study. Mediterranean Osteoporosis Study. J Bone Miner Res 1995; 10: 1802-15.
Cooper C, O'Neill T, Silman A. The epidemiology of vertebral fractures. European Vertebral Osteoporosis Study Group. Bone 1993; 14: S89-97.
O’Neill TW, Felsenberg D, Varlow J, Cooper C, Kanis JA, Silman AJ. The prevalence of vertebral deformity in European men and women: the European Vertebral Osteoporosis Study. J Bone Miner Res 1996; 11: 1010–18.
Grados F, Marcelli C, Dargent-Molina P, Roux C, Vergnol JF, Meunier PJ et al. Prevalence of vertebral fractures in French women older than 75 years from the EPIDOS study. Bone 2004; 34: 362-7. Jackson SA, Tenenhouse A, Robertson L. Vertebral fracture definition from population-based data: preliminary results from the Canadian Multicenter Osteoporosis Study (CaMos). Osteoporos Int 2000; 11: 680–7.
Kanis JA, Oden A, Johnell O, Jonsson B, De Laet C, Dawson A. The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporos Int 2000; 12: 417–27.
Kanis JA, Borgstrom F, Johnell O, Jonsson B. Cost-effectiveness of risedronate for the treatment of osteoporosis and prevention of fractures in postmenopausal women. Osteoporos Int 2004; 15: 862–71.
Ismail AA, Cooper C, Felsenberg D, Varlow J, Kanis JA, Silman J et al. Number and type of vertebral deformities: epidemiological characteristics and relation to back pain and height loss. European Vertebral Osteoporosis Study Group. Osteoporosis Int 1999; 9: 206-13.
Ferrar L, Jiang G, Adams J, Eastell R. Identification of vertebral fractures: an update. Osteoporos Int 2005; 16: 717-28.
Lesic A, Jarebinski M, Pekmezovic T, Bumbasirevic M, Spasovski D, Atkinson HD. Epidemiology of hip fractures in Belgrade, Serbia Montenegro,1990–2000. Arch Orthop Trauma Surg 2007; 127: 179-83.
De Laet CE, Pols HA. Fractures in the elderly: epidemiology and demography. Baillieres Best Pract Res Clin Endocrinol Metab 2000; 14: 171-9.
Girman CJ, Chandler JM, Zimmerman SI, Martin AR, Hawkes W, Hebel JR et al. Prediction of fracture in nursing home residents. J Am Geriatr Soc 2002; 50: 1341–7.
Greenspan SL, Myers ER, Maitland LA, Resnick NM, Hayes WC. Fall severity and bone mineral density as risk factors for hip fracture in ambulatory elderly. JAMA 1994; 271: 128–33.
Ensrud KE, Lipschutz RC, Cauley JA, Seeley D, Nevitt MC, Scott J et al. Body size and hip fracture risk in older women: a prospective study. Study of Osteoporotic Fractures Research Group. Am J Med 1997; 103: 274–80.
Alfaro-Acha A, Ostir GV, Markides KS, Ottenbacher KJ. Cognitive status, body mass index, and hip fracture in older Hispanic adults. Am Geriatr Soc 2006; 54: 1251-5.
Baddoura R, Arabi A, Haddad-Zebouni S, Khoury N, Salamoun M, Ayoub G et al. Vertebral fracture risk and impact of database selection on identifying elderly Lebanese with osteoporosis. Bone 2007; 40: 1066-72.
LaFleur J, McAdam-Marx C, Kirkness C, Brixner DI. Clinical risk factors for fracture in postmenopausal osteoporotic women: a review of the recent literature. Ann Pharmacother 2008; 3: 375- 86.
Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. Br Med J 1996; 312: 1254-9.
Blake GM, Knapp KM, Spector TD, Fogelman I. Predicting the risk of fracture at any site in the skeleton: are all bone mineral density measurement sites equally effective? Calcif Tissue Int 2006; 78: 9-17.