Mehmet Ali ERGÜN, Ayşegül ÖZGÖK, Seyhan YAĞAR, Zeliha Aslı DEMİR, Bahar AYDINLI, Derya KARAER, Mustafa Necmi İLHAN

Evaluation of dose-related genotoxicity of desfl urane by SCE human lymphocytes

Amaç: İnhalasyon anesteziklerinin potansiyel genotoksisitesi literatürde farklı sonuçları bulunan ve çalışmaları halen devam eden bir konudur. Yaygın kullanılan inhalasyon ajanlarının genotoksik güvenliğini belirlemek hastalarda ajan seçiminde önemlidir. Yöntem ve gereç: Bu çalışma desfluranın doza bağlı genotoksisitesini araştırmak amacıyla planlandı. Çalışmaya 2 grup dahil edildi, 1 grup 0,5 MAC, diğer grup 1 MAC desfluran ile idame edildi. Bazal ve anestezinin 3. saatindeki kan örnekleri SCE assay test ile çalışıldı. Bulgular: Her iki grupta da bazal SCE oranı anestezinin 3. saatinde artmış olarak bulundu. Fakat 1 MAC grubundaki bazale göre anestezinin 3. saatindeki artış istatistiksel olarak anlamlıydı. Sonuç: Desfluranın genotoksisitesiyle ilgili sınırlı bilgi mevcuttur. SCE frekanslarını çalışarak 1 MAC desfluranın genotoksik etkilerini belirledik.

Desfl uran genotoksisitesinin insan lenfositlerinde SCE ile değerlendirilmesi

Aim: To evaluate dose-related genotoxicity of desflurane. In the literature, there are studies with equivocal data regarding the potential genotoxicity of inhalational anesthetics. However, it is important to know about the genotoxic safety of an anesthetic agent. Materials and methods: Two groups were enrolled into the study. The first group was maintained with a desflurane minimum alveolar concentration (MAC) of 0.5 and the second was maintained with 1 MAC of desflurane. Blood samples were obtained and studied at the baseline and after 3 h of anesthesia via sister chromatid exchange (SCE) assay. Results: In both groups, SCEs per cell were noted to increase after 3 h of anesthesia, though the increase was only significant in the 1 MAC group. Conclusion: There are limited data on the genotoxicity of desflurane. It seems that 1 MAC of desflurane has a genotoxic effect, as shown by SCE assay.

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