Sema KARAKAŞ, Cihan KAYA, Hakan GÜRASLAN, Damlanur SAKIZ, Sema Süzen ÇAYPINAR, Hüseyin CENGİZ, Murat EKİN, Levent YAŞAR

7837

Effect of metformin and detorsion treatment on serum anti-Müllerian hormone levels and ovarian histopathology in a rat ovarian torsion model

Background/aim: Adnexal torsion is a common gynaecological emergency, and considered to be a problem mostly in reproductive-age women. To evaluate the effect of metformin and detorsion treatment on reducing ovarian reserve in an ovarian torsion model. Materials and methods: Twenty-four nonpregnant, Wistar Hannover rats were included in the study. Animals were divided into 3 groups: the control group, the detorsion only group, and the metformin + detorsion group. The first group received only laparotomy. In the second group, ovaries were fixed to the abdominal wall after performing 360° ovarian torsion, followed by detorsion after a 3-h period of ischemia. The third group underwent the same torsion and detorsion procedures as the second group, and received 50 mg/kg metformin by gavage for 14 days. Ovarian damage scores, follicle counts, and AMH levels were evaluated. Results: The total damage score was significantly increased in the detorsion only group compared to the metformin+detorsion and control groups. Pre-operative/post-operative AMH decreases were statistically significant in negative direction in the detorsion only group when compared to the metformin+detorsion and control groups P = 0.001 . Conclusion: Metformin+detorsion treatment may be effective in protecting the ovarian reserve after ovarian torsion.
Keywords:

anti-Müllerian hormone, detorsion, metformin, ovarian reserve, ovarian torsion,

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Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
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