Nalan Metin AKSU, Meltem AKKAŞ, Aydan USMAN, Neşe ÇINAR, Duygu YAZGAN AKSOY, Fatma UÇAR, Bülent Okan YILDIZ

Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia

Background/aim: Acute hyperglycemia is generally a frequently encountered condition in the emergency department (ED), becauseit is seen as a complication of diabetes mellitus (DM). In this study, we aimed to detect the change in adiponectin levels during acutehyperglycemic states and after normalization of blood glucose with insulin treatment.Materials and methods: Forty-eight patients over the age of 18 years who were admitted to the ED with acute hyperglycemia wereincluded in the study. Serum samples were taken from patients on admission and 6 h after the normalization of blood glucose withinsulin treatment, and adiponectin levels were measured in both samples.Results: There were 21 female and 27 male patients with a median age of 58.7 ± 18 years. All patients’ blood glucose levels werenormalized with insulin treatment according to international recommendations. Serum adiponectin levels decreased significantly afterthe normalization of blood glucose in the whole group. Adiponectin levels decreased from 28.9 ± 16.5 to 12.1 ± 10.9 μg/mL (P < 0.0001)in the whole group. This decrease was independent of diabetes type and body mass index.Conclusion: Normalization of blood glucose in patients with hyperglycemia caused a decrease in adiponectin levels, independentof diabetes type and/or body weight in an acute emergency setting. Inhibited upregulation of adiponectin secretion and/or bluntedsuppressive effect of insulin due to hyperglycemia or exogenous insulin administration may have caused the decrease in adiponectinlevels.

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