Muhammad MEMON, Ian MACDONALD, Terence BENNETT

Effect of mental stress on cardiovascular function at rest and after ingestion of fructose or sucralose in healthy, white European males

Ingestion of fructose and mental arithmetic can increase blood pressure (BP); the present study assessed the effect of fructose ingestion on cardiovascular (CV) response to mental stress. Effects were compared with sucralose used as a control. Materials and methods: Ten healthy, white European males were studied twice. A Finometer recorded CV parameters, noninvasively, throughout the study period. After the 30-min baseline, a mental arithmetic task (MAT), a series of arithmetic questions displayed as PowerPoint slides, was presented. Subjects, while resting on a bed, answered 20 questions in 2 min; 15 min after MAT-1, volunteers consumed 500 mL of lemon-flavoured drink containing either fructose (0.75 g/kg body weight) or sucralose. Thirty minutes after drinking, MAT-2, using different questions, was administered; measurements continued for 30 min afterwards. The same protocol was repeated with new questions on a different day with the alternative drink, containing either fructose or sucralose. Results: Fructose and sucralose increased BP and total peripheral resistance (TPR). MATs increased BP, heart rate, and cardiac index, whereas TPR decreased. CV responses to mental arithmetic were not affected by fructose or sucralose, except for an attenuated increase in SBP during MAT-2 after fructose. Conclusion: Pressor effects of fructose (or sucralose) and MATs are not additive.

Anahtar Kelimeler:

Key words: Fructose, sucralose, mental stress, cardiovascular function, Finometer

Effect of mental stress on cardiovascular function at rest and after ingestion of fructose or sucralose in healthy, white European males

Keywords:

Key words: Fructose, sucralose, mental stress, cardiovascular function, Finometer,

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Das S, O’Keefe JH. Behavioral cardiology: recognizing and addressing the profound impact of psychosocial stress on cardiovascular health. Curr Atheroscler Rep 2006; 8: 111–118.
Lampert R, Jain D, Burg MM, Batsford WP, McPherson CA. Destabilizing effects of mental stress on ventricular arrhythmias in patients with implantable cardioverter- defibrillators. Circulation 2000; 101: 158–164. 3. Krantz DS, Quigley JF, O’Callahan M. Mental stress as a trigger of acute cardiac events: the role of laboratory studies. Ital Heart J 2001; 2: 895–899. 4.
Harris CW, Edwards JL, Baruch A, Riley WA, Pusser BE, Rejeski
WJ, Herrington DM. Effects of mental stress on brachial artery
flow-mediated vasodilation in healthy normal individuals. Am
Heart J 2000; 139: 405–411.
Liu X, Iwanaga K, Shimomura Y, Katsuura T. The reproducibility of cardiovascular response to a mental task. J Physiol Anthropol 2010; 29: 35–41.
Krantz DS, Helmers KF, Bairey CN, Nebel LE, Hedges SM, Rozanski A. Cardiovascular reactivity and mental stress- induced myocardial ischemia in patients with coronary artery disease. Psychosom Med 1991; 53: 1–12. 7. Robinson BF. Relation of heart rate and systolic blood pressure to the onset of pain in angina pectoris. Circulation 1967; 35: 1073–1083.
Bray GA. Soft drink consumption and obesity: it is all about fructose. Curr Opin Lipidol 2010; 21: 51–57.
Malik VS, Schulze MB, Hu FB. Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J Clin Nutr 2006; 84: 274–288.
Bray GA, Nielsen SJ, Popkin BM. Consumption of high- fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 2004; 79: 537-543.
Ertin H, Özaltay B. Some ethical reflections on weight-loss diets. Turk J Med Sci 2011; 41: 951–957.
Itagi V, Patil R. Obesity in children and adolescents and its relationship with hypertension. Turk J Med Sci 2011; 41: 259– 266.
Karasen RM, Çiftçi B, Acar B, Yalçın AA, Fırat Güven S. Heart rate recovery in patients with obstructive sleep apnea syndrome. Turk J Med Sci 2012; 42: 964–969.
Memon MQ, Bennett T, Macdonald IA. Haemodynamic effects of fructose and sucralose in healthy, white Caucasian males. J Liaquat Uni Med Health Sci 2011; 10: 3–10.
Brown CM, Dulloo AG, Yepuri G, Montani JP. Fructose ingestion acutely elevates blood pressure in healthy young humans. Am J Physiol Regul Integr Comp Physiol 2008; 294: R730–R737.
Baird IM, Shephard NW, Merritt RJ, Hildick-Smith G. Repeated dose study of sucralose tolerance in human subjects. Food Chem Toxicol 2000; 38: S123–S129.
Prkachin KM, Mills DE, Zwaal C, Husted J. Comparison of hemodynamic responses to social and nonsocial stress: evaluation of an anger interview. Psychophysiology 2001; 38: 879–885.
Reims H, Sevre K, Fossum E, Hoieggen A, Eide I, Kjeldsen SE. Plasma catecholamines, blood pressure responses and perceived stress during mental arithmetic stress in young men. Blood Press 2004; 13: 287–294.
Schoder H, Silverman DH, Campisi R, Sayre JW, Phelps ME, Schelbert HR, Czernin J. Regulation of myocardial blood flow response to mental stress in healthy individuals. Am J Physiol Heart C 2000; 278: H360–H366.
Becker LC, Pepine CJ, Bonsall R, Cohen JD, Goldberg AD, Coghlan C, Stone PH, Forman S, Knatterud G, Sheps DS et al. Left ventricular, peripheral vascular and neurohumoral responses to mental stress in normal middle-aged men and women. Reference Group for the Psychophysiological Investigations of Myocardial Ischemia (PIMI) Study. Circulation 1996; 94: 2768–2777.
Fellows IW, Bennett T, MacDonald IA. The effect of adrenaline upon cardiovascular and metabolic functions in man. Clin Sci 1985; 69: 215–222.