Effect of Lactation on Bone Mineral Density Later in Life in Turkish Women

Aim: To investigate the probable effect of lactation on bone mineral density (BMD) later in life. Materials and Methods: Eighty-seven premenopausal and 18 postmenopausal Turkish women were classified into four groups according to age. Age, height, weight, menopausal status, age at menopause (in postmenopausal women), years since menopause (in postmenopausal woman), parity and total lactation period were recorded. Lumbar spine BMD (L2-L4) was measured by dual-energy X-ray absorptiometry (DEXA). In each group, correlations of lactation with BMD were investigated using Pearson correlation test, and multiple regression analyses were used to determine the factors associated with BMD. Results: No significant correlation was determined between total lactation period and BMD in any subgroup. This result did not change after adjusting for age, height, weight and parity. Conclusions: Total lactation period does not seem to be a determinant of BMD later in life in Turkish women.

Effect of Lactation on Bone Mineral Density Later in Life in Turkish Women

Aim: To investigate the probable effect of lactation on bone mineral density (BMD) later in life. Materials and Methods: Eighty-seven premenopausal and 18 postmenopausal Turkish women were classified into four groups according to age. Age, height, weight, menopausal status, age at menopause (in postmenopausal women), years since menopause (in postmenopausal woman), parity and total lactation period were recorded. Lumbar spine BMD (L2-L4) was measured by dual-energy X-ray absorptiometry (DEXA). In each group, correlations of lactation with BMD were investigated using Pearson correlation test, and multiple regression analyses were used to determine the factors associated with BMD. Results: No significant correlation was determined between total lactation period and BMD in any subgroup. This result did not change after adjusting for age, height, weight and parity. Conclusions: Total lactation period does not seem to be a determinant of BMD later in life in Turkish women.

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  • [No authors listed]. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 1993; 94: 646-50. 2. Kanis JA, Melton LJ 3rd, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. J Bone Miner Res 1994; 9: 1137-41. 3.
  • More C, Bettembuk P, Bhattoa HP, Balogh A. The effects of
  • pregnancy and lactation on bone mineral density. Osteoporos Int 2001; 12: 732-7. 4.
  • Nguyen TV, Jones G, Sambrook PN, White CP, Kelly PJ, Eisman
  • JA. Effects of estrogen exposure and reproductive factors on
  • bone mineral density and osteoporotic fractures. J Clin Endocrinol
  • Jones G, Scott FS. A cross-sectional study of smoking and bone mineral density in premenopausal parous women: effect of body mass index, breast feeding and sports participation. J Bone Miner Res 1999; 14: 1628-33.
  • Feldblum PJ, Zhang J, Rich LE, Fortney JA, Talmage RV. Lactation history and bone mineral density among perimenopausal women. Epidemiology 1992; 3: 527-31.
  • Sowers M, Wallace RB, Lemke JH. Correlates of forearm bone mass among women during maximal bone mineralization. Prev Med 1985; 14: 585-596.
  • Bauer DC, Browner WS, Cauley JA, Orwoll ES, Scott JC, Black DM et al. Factors associated with appendicular bone mass in older women. The Study of Osteoporotic Fractures Research Group. Ann Intern Med 1993; 118: 657-65.
  • Kent GN, Price RI, Gutteridge DH, Smith M, Allen JR, Bhagat CI et al. Human lactation: forearm trabecular bone loss, increased bone turnover, and renal conservation of calcium and inorganic phosphate with recovery of bone mass following weaning. J Bone Miner Res 1990; 5: 361-9.
  • Lamke B, Brundin J, Moberg P. Changes of bone mineral content during pregnancy and lactation. Acta Obstet Gynecol Scand 1977; 56: 217-9.
  • Hu JF, Zhao XH, Chen JS, Fitzpatrick J, Parpia B, Campbell TC. Bone density and lifestyle characteristics in premenopausal and postmenopausal Chinese women. Osteoporos Int 1994; 4: 288- 97.
  • Specker BL, Tsang RC, Ho ML. Changes in calcium homeostasis over the first year postpartum: effect of lactation and weaning. Obstet Gynecol 1991; 78: 56-62.
  • Hayslip CC, Klein TA, Wray HL, Duncan WE. The effect of lactation on bone mineral content in healthy postpartum women. Obstet Gynecol 1989; 73: 588-92.
  • Johansen JS, Riis BJ, Hassager C, Moen M, Jacobson J, Christiansen C. The effect of a gonadotropin-releasing hormone agonist analog (nafarelin) on bone metabolism. J Clin Endocrinol Metab 1988; 67: 701-6.
  • Cumming RG, Klineberg RJ. Breastfeeding and other reproductive factors and the risk of hip fractures in elderly women. Int J Epidemiol 1993; 22: 684-91.
  • Sowers MF, Hollis BW, Shapiro B, Randolph J, Janney CA, Zhang D et al. Elevated parathyroid hormone related peptide associated with lactation and bone density loss. JAMA 1996; 276: 549-54.
  • Kolthoff N, Eiken P, Kristensen B, Nielsen SP. Bone mineral changes during pregnancy and lactation: a longitudinal cohort study. Clin Sci (Lond) 1998; 94: 405-12.
  • Karagas MR, Lu-Yao GL, Barrett JA, Beach ML, Baron JA. Heterogeneity of hip fracture: age, race, sex, and geographic patterns of femoral neck and trochanteric fractures among the US elderly. Am J Epidemiol 1996; 143: 677-82.
  • Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S. Genetic determinants of bone mass in adults. A twin study. J Clin Invest 1987; 80: 706-10.
  • Prior JC, Vigna YM, Barr SI, Rexworthy C, Lentle BC. Cyclic medroxyprogesterone treatment increases bone density: a controlled trial in active women with menstrual cycle disturbances. Am J Med 1994; 96: 521-30.
  • Sowers M. Pregnancy and lactation as risk factors for subsequent bone loss and osteoporosis. J Bone Miner Res 1996; 11: 1052- 60.
  • Cumming RG. Calcium intake and bone mass: a quantitative review of the evidence. Calcif Tissue Int 1990; 47: 194-201.
  • Hagemans ML, van der Schouw YT, de Kleijn MJ, van Staveren WA, Pop VJ, Leusink GL et al. Indicators for the total duration of premenopausal endogenous estrogen exposure in relation to BMD. Hum Reprod 2004; 19: 2163-9.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
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