Effect of 4 weeks of frankincense consumption on explicit motor memory and serum BDNF in elderly men

Effect of 4 weeks of frankincense consumption on explicit motor memory and serum BDNF in elderly men

Background/aim: Memory is a mechanism for coding, storing, and recalling information. Weak memory and learning disability arecommon psychological problems in the elderly. The aim of this study was to investigate the effect of 4 weeks of frankincense consumptionon explicit motor memory and serum BDNF in the elderly.Materials and methods: Twenty elderly men (mean age of 60.2 ± 1.7 years) were randomly divided into two groups: experimental (n= 12) and placebo (n = 8). The first blood samples were collected 24 h before the pretest. Then both groups participated in a 4-weekexercise program based on the protocol of exercising motor memory. During this period, the experimental group received 500-mgfrankincense pills two times a day. The second blood sample collection and acquisition test were conducted following the last session ofthe exercise program. A retention test and a third blood sampling were performed 2 weeks after the last training session. Mixed analysisof variance (2 × 3) for repeated measures was used to analyze the data.Results: Intergroup comparisons showed that frankincense had a significant effect on the acquisition and retention of explicit motormemory. No difference was observed in serum BDNF between the experimental and placebo groups.Conclusion: This study revealed that 4 weeks of frankincense consumption facilitates the acquisition and retention of motor memoryin older men with moderate mental status.

___

  • 1. Sharifzadeh M, Sharifzadeh K, Naghdi N, Ghahremani MH, Roghani A. Posttraining intrahippocampal infusion of a protein kinase AII inhibitor impairs spatial memory retention in rats. Journal of Neuroscience Research 2005; 79: 392-400.
  • 2. Kantak SS, Sullivan KJ, Fisher BE, Knowlton BJ, Winstein CJ. Transfer of motor learning engages specific neural substrates during motor memory consolidation dependent on the practice structure. Journal of Motor Behavior 2011; 34: 499- 507.
  • 3. Voss JL, Paller KA. Brain substrates of implicit and explicit memory: the importance of concurrently acquired neural signals of both memory types. Neuropsychologia 2008; 46: 3021-3029.
  • 4. Foster JK, Lidder PG, Sünram SI. Glucose and memory: fractionation of enhancement effects? Psychopharmacology 1990; 137: 259-270.
  • 5. Brown TP, Fenn KM, Nusbaum HC, Margoliash D. Consolidating the effects of waking and sleep on motorsequence learning. J Neurosci 2010; 30: 13977-13982.
  • 6. Kaldi AR, Akbari Kamrani AA, Foroughan M. Physical, social and mental problems of 13 areas of Tehran’s elders. Journal of Community Wellbeing 2002; 17: 233-243.
  • 7. Ataollahi Eshkoor S, Tengku Aizan H, Mun CY, Ng CK. Mild cognitive impairment and its management in older people. Clinical Interventions in Aging 2015; 10: 687-693.
  • 8. Rezende LF, Rey-Lopez JP, Matsudo VK, Carmo Luiz O. Sedentary behavior and health outcomes among older adults: a systematic review. BMC Public Health 2014; 14: 333.
  • 9. Kordower JH, Chu Y, Stebbins GT, DeKosky ST, Cochran EJ, Bennett D, Mufson EJ. Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment. Annals of Neurology 2001; 49: 202-213.
  • 10. Ronchi D, Berardi D, Menchetti M, Ferrari G, Serretti A, Dalmonte E, Fratiglioni L. Occurrence of cognitive impairment and dementia after the age of 60: a population-based study from northern Italy. Dementia and Geriatric Cognitive Disorders 2005; 1: 2-3.
  • 11. Mitchell AJ, Beaumont H, Ferguson D, Yadegarfar M, Stubbs B. Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis. Acta Psychiatrica Scandinavica 2014, 130: 409-498
  • 12. Burke DM, Mackay DG. Memory, language, and ageing. Philosophical Transactions of the Royal Society of London Series B, Biological Sciences 1997; 352: 1363.
  • 13. Reuter-Lorenz PA, Jonides J, Smith EE, Hartley A, Miller A, Marshuetz C, Koeppe PA. Age differences in the frontal lateralization of verbal and spatial working memory revealed by PET. Journal of Cognitive Neuroscience 2000; 12: 174-187.
  • 14. Small JA, Gutman G. Recommended and reported use of communication strategies in Alzheimer caregiving. Alzheimer’s Disease and Associated Disorders 2002; 16: 270-278.
  • 15. Polydoro M, Acker CM, Duff K, Castillo PE, Davies P. Agedependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. The Journal of Neuroscience 2009; 29: 10741-10749.
  • 16. Ziegenhorn AA, Schulte-Herbruggen O, Danker-Hopfe H, Malbranc M, Hartung HD, Anders D, Long UE, SteinhagenThiessen E, Schaub RT, Hellweg R. Serum neurotrophins—a study on the time course and influencing factors in a large old age sample. Neurobiology of Aging 2007; 28: 1436-1445.
  • 17. Lommatzsch M, Quarcoo D, Schulte-Herbrüggen O, Weber H, Virchow JC, Renz H, Braun A. Neurotrophins in murine viscera: a dynamic pattern from birth to adulthood. International Journal of Developmental Neuroscience 2005; 23: 495-500.
  • 18. Canivet A, Cedric TA, Andre N, Pylouster J, RodríguezBallesteros M, Kitzis A, Audiffren M. Effects of BDNF polymorphism and physical activity on episodic memory in the elderly: a cross sectional study. European Review of Aging and Physical Activity 2015; 12: 15.
  • 19. Aydemir C, Yalcin ES, Akaaray S, Kisa C, Yildirim SG, Uzbay T, Goka E. Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women. Progress in NeuroPsychopharmacology and Biological Psychiatry 2006; 30: 1256-1260.
  • 20. Nakazaton M, Hashimoto K, Shimizu E, Kumakiri C, Koizumi H, Okamura N, Mitsumori M, Komatsu N, Iyo M. Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders. Biological Psychiatry 2003; 54: 485-490.
  • 21. Mahboubi M, Taghizadeh M, Talaei SA, Takhtfirozeh SM., Rashidi AA, Tamtaji OR. Combined administration of Melissa officinalis and Boswellia serrata extracts in an animal model of memory. Iranian Journal of Psychiatry and Behavioral Sciences 2016; 10: e681.
  • 22. Davis R, Massman PJ, Doody RS. Cognitive intervention in Alzheimer disease: a randomized placebocontrolled study. Alzheimer Disease & Associated Disorders 2001; 15: 1-9.
  • 23. Posadzki P, Watson LK, Alotaibi A, Ernst E. Prevalence of herbal medicine use by UK patients/consumers: a systematic review of surveys. Focus Altern Complement Ther 2013; 18: 19-26.
  • 24. Catanzaro D, Rancan S, Orso G, Dall’Acqua S, Brun P, Giron MC, M Carrara, Castagliuolo I, Ragazzi E, Caparrotta L et el. Boswellia serrata preserves intestinal epithelial barrier from oxidative and inflammatory damage. PLOS One 2015; 10: 5.
  • 25. Hosseini-Sharifabad M, Kamali-Ardakani R, HosseiniSharifabad A. Beneficial effect of Boswellia serrata gum resin on spatial learning and the dendritic tree of dentate gyrus granule cells in aged rats. Avicenna Journal of Phytomedicine 2016; 6: 189-197.
  • 26. Singh GB, Atal CK. Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new nonsteroidal anti-inflammatory agent. Agents Actions 1986; 18: 407-412.
  • 27. Mahmoudi A, Hosseini-Sharifabad A, Monsef-Esfahani HR, Yazdinejad AR, Khanavi M, Roghani A, Beyer C, Sharifzadeh M. Evaluation of systemic administration of Boswellia papyrifera extracts on spatial memory retention in male rats. Journal of Natural Medicines 2011; 65: 519-525.
  • 28. Hosseini M, Hadjzadeh MA, Derakhshan M, Havakhah S, Rassouli FB, Rakhshandeh H, Saffarzadeh F. The beneficial effects of olibanum on memory deficit induced by hypothyroidism in adult rats tested in Morris water maze. Archives of Pharmacal Research 2010; 33: 463-468.
  • 29. Aghajani M, Taghizadeh M, Maghaminejad F, Rahmani M. Effect of frankincense extract and lemon balm extract cosupplementation on memory of the elderly. Complementary Medicine Journal 2017; 7: 3.
  • 30. Givad N, Rafieian Kopaei M, Rezaei Kheirabadi F, Khosravi SH, Azizi M. A study of the clinical efficacy of frankincense in the acute phase of ischemic stroke. Journal of Advanced Herbal Medicine 2015; 1: 4-10.
  • 31. Sedighi B, Pardakhty A, Kamali H, Shafiee K, Hasani BN. Effect of Boswellia papyrifera on cognitive impairment in multiple sclerosis. Iranian Journal of Neurology 2014; 13: 149-153.
  • 32. Hamidpour R, Hamidpour S, Hamidpour M, Hamidpour R. Frankincense (Boswellia species): the novel phytotherapy for drug targeting in cancer. Archives in Cancer Research 2016; 1: 46.
  • 33. Sadeghi F, Khalaj-Kondori M, Hosseinpour Feizi MA, Shaikhzadeh Hesari F. The effect of aqueous extract of Boswellia on learning and spatial memory in adult male rats. Journal of Zanjan University of Medical Sciences 2014; 22: 122-131.
  • 34. Khalaj-Kondori M, Sadeghi F, Hosseinpourfeizi MA, Shaikhzadeh-Hesari F, Nakhlband A, Rahmati-Tamchi M. Boswellia serrata gum resin aqueous extract upregulates BDNF but not CREB expression in adult male rat hippocampus. Turkish Journal of Medical Sciences 2016; 46: 1573-1578.
  • 35. Ghasemi M, Hosseini H, Sabouhi F. The effect of peer group training on self-care of elderly with diabetes mellitus. Journal of Clinical Nursing and Midwifery 2017; 6: 33-43.
  • 36. Alipour A, Agah Haris M. Reliability and validity of the Edinburgh handedness questionnaire in Iran. Journal of Psychological Sciences 2007; 1: 117-133.
  • 37. Seyedian M, Fallah M, Nowroozian M, Nejat S, Delaware A, Ghasemzadeh H. Preparation and validation of the Persian version of the Mini-Mental State Examination. Medical Science Organization Scientific Journal 2007; 25: 408-414.
  • 38. Mirakhori F, Arabiameri E, Bagherzadeh F, Hemayattalab R, Pourazar M. The effect of focusing attention on acquisition, retention and transfer of linear motion in children with cerebral palsy. 10th International Congress of Sport Sciences; 26–27 April 2017; Tehran. Iran. doi: 10.22089/10thconf.2017.633
  • 39. Krohn K, Rao MS, Raman NV, Khalilullah M. HPTLC analysis of anti-inflammatory triterpenoids from Boswellia serrata Roxb. Phytochemical Analysis 2001; 12: 374-376.
  • 40. Rall, B, Ammon HP, Safayhi H. Boswellic acids and protease activities. Phytomedicine 1996; 3: 75-76.
  • 41. Shah SA, Rathod IS, Suhagia BN, Pandya SS, Parmar VK. A simple high-performance liquid chromatographic method for the estimation of boswellic acids from the market formulations containing Boswellia serrata extract. J Chromatogr Sci 2008; 46: 735-738.
  • 42. Vahidi A, Dashti M, Frozanmehr M, Nadi M, Eftekhar Afzali M, Baktash A, Pakdel S. Evaluating the effect of frankincense on learning and memory of the rat during breastfeeding. Journal of Shaheed Sadoughi University of Medical Sciences and Health Yazd 2003; 11: 47.
  • 43. Karima O, Riazi G, Yousefi R, Moosavi Movahedi AA. The enhancement effect of beta-boswellic acid on hippocampal neurites outgrowth and branching (an in vitro study). Neurological Sciences 2010; 31: 315-320.
  • 44. Himeda T, Mizuno K, Kato H, Araki T. Effects of age on immunohistochemical changes in the mouse hippocampus. Mechanisms of Ageing and Development 2005; 126: 673-677.
  • 45. Alkon DL, Sun M, Nelson TJ. PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer’s disease. Trends Pharmacol Sci 2007; 28: 51-60.
  • 46. Sharifzadeh M, Aghsami M, Gholizadeh S, Tabrizian K, Soodi M, Khalaj S, Ranjbar A, Hosseini-Sharifabad A, Roghani A, Karimfar MH. Protective effects of chronic lithium treatment against spatial memory retention deficits induced by the protein kinase AII inhibitor H-89 in rats. Pharmacology 2007; 80: 158-165.
  • 47. Moussaieff A, Shein NA, Tsenter J, Grigoriadis S, Simeonidou C, Alexandrovich AG, Trembovler V, Ben-Neriah Y, Schmitz ML, Fiebich BL et al. Incensole acetate - a novel neuroprotective agent isolated from Boswellia carterii. Journal of Cerebral Blood Flow & Metabolism 2008; 28: 1341-1352.
  • 48. Dhingra D, Parle M, Kulkarni S. Memory enhancing activity of Glycyrrhiza glabra in mice. J Ethnopharmacol 2004; 91: 361- 365.
  • 49. Rainer E. Use of frankincense (olibanum) in the treatment of Alzheimer’s disease. Chem ABS 1996; 125: 1327-1394.
  • 50. Kruger PH, Daneshfar R, Eckert GP, Klein J, Volmer DA, Bahr U, Müller ME, Karas M, Schubert-Zsilavecz M, Abdel-Tawab M. Metabolism of boswellic acids in vitro and in vivo. Drug Metabolism and Disposition 2008; 36: 1135-1142.
  • 51. Dudai Y. The Neurobiology of Memory: Concepts, Findings, Trends. 1st ed. New York, NY, USA: Oxford University Press; 1989.
  • 52. Pluchino N, Cubeddu A, Begliuomini S, Merlini S, Giannini A, Bucci F, Casarosa E, Luisi M, Cela V, Genazzani AR. Daily variation of brain-derived neurotrophic factor and cortisol in women with normal menstrual cycles, undergoing oral contraception and in postmenopause. Human Reproduction 2009; 24: 2303-2309.
  • 53. Kirk Sanchez NJ, McGough EL. Physical exercise and cognitive performance in the elderly: current perspectives. Clinical Interventions in Aging. 2014; 9: 51-62.
  • 54. Swift DL, Johannsen NM, Myers VH, Earnest CP, Smits JAJ, Blair SN, Church TS. The effect of exercise training modality on serum brain derived neurotrophic factor levels in individuals with type 2 diabetes. PLOS One 2012; 7: 1-7.
  • 55. Silverman MN, Deuster PA. Biological mechanisms underlying the role of physical fitness in health and resilience. Interface Focus 2014; 4: 1-12.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK