Do PD-1 and PD-L2 expressions have prognostic impact in hematologic malignancies?

Öz Background/aim: PD-1 (programmed death-1) is an immune checkpoint receptor that modulates T-cell activity in peripheral tissues via interaction with its ligands, PD-L1 (programmed death-ligand 1) and PD-L2 (programmed death-ligand 2). Tumor cells upregulate PD-L1 or PD-L2 to inhibit this T lymphocyte attack. Our goal was to determine the PD-1 and PD-L2 expression rates of various hematologic malignancies, and evaluate whether PD-1 and PD-L2 expressions have an impact on prognosis. Materials and methods: For this purpose, pretreatment bone marrow biopsy specimens of 83 patients [42 multiple myeloma (MM), 21 acute leukemia, and 20 chronic lymphocytic leukemia (CLL)] were stained with monoclonal antibody immunostains of PD-1 and PD-L2. Results: As a result, the overall expression rate of PD-1 was 26.2%, 4.8%, and 60% in patients with MM, acute leukemia, and CLL, respectively, whereas the PD-L2 expression rate was 61.9%, 14.3%, and 10% in patients with MM, acute leukemia, and CLL, respectively. Conclusion: Finally, we concluded that the role of the PD-1 pathway can be demonstrated by immunohistochemistry (IHC). Since we evaluated whether there is a correlation between the (IHC) results and survival of patients with MM, acute leukemia, and CLL, we could not demonstrate meaningful evidence that these markers have an impact on prognosis.

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Bibtex @ { tbtkmedical577812, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2019}, volume = {49}, pages = {265 - 271}, doi = {}, title = {Do PD-1 and PD-L2 expressions have prognostic impact in hematologic malignancies?}, key = {cite}, author = {Korkmaz, Serdal and Erdem, Selahattin and Akay, Ebru and Taşdemir, Erdem Arzu and Karaman, Hatice and Keklik, Muzaffer} }
APA Korkmaz, S , Erdem, S , Akay, E , Taşdemir, E , Karaman, H , Keklik, M . (2019). Do PD-1 and PD-L2 expressions have prognostic impact in hematologic malignancies? . Turkish Journal of Medical Sciences , 49 (1) , 265-271 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577812
MLA Korkmaz, S , Erdem, S , Akay, E , Taşdemir, E , Karaman, H , Keklik, M . "Do PD-1 and PD-L2 expressions have prognostic impact in hematologic malignancies?" . Turkish Journal of Medical Sciences 49 (2019 ): 265-271 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577812>
Chicago Korkmaz, S , Erdem, S , Akay, E , Taşdemir, E , Karaman, H , Keklik, M . "Do PD-1 and PD-L2 expressions have prognostic impact in hematologic malignancies?". Turkish Journal of Medical Sciences 49 (2019 ): 265-271
RIS TY - JOUR T1 - Do PD-1 and PD-L2 expressions have prognostic impact in hematologic malignancies? AU - Serdal Korkmaz , Selahattin Erdem , Ebru Akay , Erdem Arzu Taşdemir , Hatice Karaman , Muzaffer Keklik Y1 - 2019 PY - 2019 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 265 EP - 271 VL - 49 IS - 1 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Do PD-1 and PD-L2 expressions have prognostic impact in hematologic malignancies? %A Serdal Korkmaz , Selahattin Erdem , Ebru Akay , Erdem Arzu Taşdemir , Hatice Karaman , Muzaffer Keklik %T Do PD-1 and PD-L2 expressions have prognostic impact in hematologic malignancies? %D 2019 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 49 %N 1 %R %U
ISNAD Korkmaz, Serdal , Erdem, Selahattin , Akay, Ebru , Taşdemir, Erdem Arzu , Karaman, Hatice , Keklik, Muzaffer . "Do PD-1 and PD-L2 expressions have prognostic impact in hematologic malignancies?". Turkish Journal of Medical Sciences 49 / 1 (Şubat 2019): 265-271 .
AMA Korkmaz S , Erdem S , Akay E , Taşdemir E , Karaman H , Keklik M . Do PD-1 and PD-L2 expressions have prognostic impact in hematologic malignancies?. Turkish Journal of Medical Sciences. 2019; 49(1): 265-271.
Vancouver Korkmaz S , Erdem S , Akay E , Taşdemir E , Karaman H , Keklik M . Do PD-1 and PD-L2 expressions have prognostic impact in hematologic malignancies?. Turkish Journal of Medical Sciences. 2019; 49(1): 265-271.
IEEE S. Korkmaz , S. Erdem , E. Akay , E. Taşdemir , H. Karaman ve M. Keklik , "Do PD-1 and PD-L2 expressions have prognostic impact in hematologic malignancies?", Turkish Journal of Medical Sciences, c. 49, sayı. 1, ss. 265-271, Şub. 2019

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