Comparison of venous repair results using either arterial or vein grafts in a crushavulsion injury model

Comparison of venous repair results using either arterial or vein grafts in a crushavulsion injury model

Background/aim: Venous insufficiency after replantation or revascularization is one of the most common causes of limb loss in eitherthe short or the long term. The aim of this study was to evaluate the results of a new technique to overcome venous insufficiency.Materials and Methods: A crush-avulsion type of injury was formed in the femoral veins of rats of 3 separate groups. In the controlgroup, primary repair was applied to the damaged veins and the remaining 2 groups were repaired with either an arterial graft or a veingraft. The success rates of anastomosis were then compared.Results: In the control group the patency rate was 25% in the 2nd hour, 12.5% on the 2nd day, and 12.5% on the 10th day. The patencyrate in the vein group was 87.5% in the 2nd hour, 50% on the 2nd day, and 37.5% on the 10th day, whereas the patency rates in the arterygroup were 100% in the 2nd hour, 87.5% on the 2nd day, and 75% on the 10th day.Conclusion: Microsurgery requires experience and patience. It can be considered that the use of arterial grafts for venous repair inreplantation after crush-avulsion type amputations can increase the success rate of replantation.

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  • 1. Saha SS, Pandey A, Parwal C. Arterial segments as microvascular interposition grafts in venous anastomosis in digital replantations. Indian J Plast Surg 2015; 48: 166-171.
  • 2. Tamai S. Twenty years’ experience of limb replantation: Review of 293 upper extremity replants. J Hand Surg Am 1982; 7: 549- 556.
  • 3. Lykoudis EG, Panayotou PN, Stamatopoulos CN, Frangia KB, Papalois AE, Ioannovich JD. Microvascular repair following a modified crush-avulsion injury in a rat model: effect of recombinant human tissue-type plasminogen activator on the patency rate. Microsurgery 2000; 20: 52-58.
  • 4. Narasimhan K, Griffin JR, Thornton JF. Microsurgery. Selected Readings in Plastic Surgery 2014; 11: 1-57.
  • 5. Manicone JA, Eisenbud DE, Hertz SM, Brener BJ, Creighton D, Villanueva A, Marak J, Rose D, Parsonnet V. The effect of thrombus on the vascular endothelium of arterialized vein grafts. Am J Surg 1996; 172: 163-166.
  • 6. Clarkson TB, Weingand KW, Kaplan JR, Adams MR. Mechanisms of atherogenesis. Circulation 1987; 76: 120-128.
  • 7. Mitchell GM, Morrison WA, Papadopoulos A, O’Brien BM. A study of the extent and pathology of experimental avulsion injury in rabbit arteries and veins. Br J Plast Surg 1985; 38: 278- 287.
  • 8. Shukla N, Jeremy JY. Pathophysiology of saphenous vein graft failure: a brief overview of interventions. Curr Opin Pharmacol 2012; 12: 114-120.
  • 9. Motwani JG, Topol EJ. Aortocoronary saphenous vein graft disease: pathogenesis, predisposition, and prevention. Circulation 1998; 97: 916-931.
  • 10. Graaf R, Tintu A, Stassen F, Kloppenburg G, Bruggeman C, Rouwet E. Nacetylcysteine prevents neointima formation in experimental venous bypass grafts. Br J Surg 2009; 96: 941-950.
  • 11. Rothuizen TC, Damanik FF, Lavrijsen T, Visser MJ, Hamming JF, Lalai RA, Duijs JMGJ, van Zonneveld AJ, Hoefer IE, van Blitterswijk CA et al. Development and evaluation of in vivo tissue engineered blood vessels in a porcine model. Biomaterials 2016; 75: 82-90.
  • 12. Zhou N, Yu QJ, Si R, Gao HK, Wang T, Gao F, Wang HC, Bian JF. Postprocedure administration of insulin in canine autologous vein grafting: a potential strategy to attenuate intimal hyperplasia. J Cardiovasc Pharmacol 2010; 56: 402- 412.
  • 13. Kurobe H, Maxfield MW, Tara S, Rocco KA, Bagi PS, Yi T, Udelsman B, Zhuang ZW, Cleary M, Iwakiri Y. Development of small diameter nanofiber tissue engineered arterial grafts. PLoS One 2015; 10: e0120328.
  • 14. Hangler HB, Pfaller K, Antretter H, Dapunt OE, Bonatti JO. Coronary endothelial injury after local occlusion on the human beating heart. Ann Thorac Surg 2001; 71: 122-127.
  • 15. Sirvan SS, Dagdelen D, Akgun Demir I, Cezairlioglu MA, Sezer HB, Karsidag S. Utilization of arterial grafts in foot replantation. Journal of Vascular Surgery Cases and Innovative Techniques 2017; 1: 44-46.
  • 16. He GW, Angus JA, Rosenfeldt FL. Reactivity of the canine isolated internal mammary artery, saphenous vein, and coronary artery to constrictor and dilator substances: relevance to coronary bypass graft surgery. J Cardiovasc Pharmacol 1988; 12: 12-22.
  • 17. Son JA, Smedts F, Vincent JG, van Lier HJ, Kubat K. Comparative anatomic studies of various arterial conduits for myocardial revascularization. J Thorac Cardiovasc Surg 1990; 99: 703-707.
  • 18. Lüscher TF, Diederich D, Siebenmann R, Lehmann K, Stulz P, von Segesser L, Yang ZH, Turina M, Grädel E, Weber E et al. Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts. N Engl J Med 1988; 319: 462-467.
  • 19. Rockwell WB, Haidenberg J, Foreman KB. Thumb replantation using arterial conduit graft and dorsal vein transposition. Plast Reconstr Surg 2008; 122: 840-843.
  • 20. Arnez ZM, Lister GD. The posterior interosseous arterial graft. Plast Reconstr Surg 1994; 94: 202-206.
  • 21. Isomura T, Hisatomi K, Inuzuka H, Nishimi M, Hirano A, Ohishi K. Morphological and functional study of free arterial grafts. Heart Vessels 1992; 7: 148-154.
  • 22. Jeremy JY, Gadsdon P, Shukla N, Vijayan V, Wyatt M, Newby A, Angelini GD. On the biology of saphenous vein grafts fitted with external synthetic sheaths and stents. Biomaterials 2007; 28: 895-908.
  • 23. Rockwell WB, Smith SM, Tolliston T, Valnicek SM. Arterial conduits for extremity microvascular bypass surgery. Plast Reconstr Surg 2003; 112: 829-834.
  • 24. Khouri RK. Avoiding free flap failure. Clin Plast Surg 1992; 19: 773-781.