Mediha TÜRKTAN, Yasemin GÜNEŞ, Hafize YALINIZ, Selçuk MATYAR, Zehra HATİPOĞLU, Ersel GÜLEÇ, Uğur GÖÇEN, Atakan ATALAY

Comparison of the cardioprotective effects of dexmedetomidineand remifentanil in cardiac surgery

Öz Background/aim: Myocardial protection is an important factor of open heart surgery and biological biomarkers (lactate, CKMB, cardiac troponin I, and pyruvate) are used to assess myocardial damage. This study compares the effects of dexmedetomidine and remifentanil on myocardial protection during coronary artery bypass grafting (CABG) surgery. Materials and methods: Patients scheduled for elective CABG surgery (n = 60) were included in this study. Anesthesia induction was introduced with propofol, fentanyl, and vecuronium bromide. Anesthesia was maintained with remifentanil infusion and sevoflurane in the remifentanil group (Group R) and with dexmedetomidine infusion and sevoflurane in the dexmedetomidine group (Group D). Blood samples for biochemical markers were taken from the coronary sinus catheter before cardiopulmonary bypass (T1), 20 min after aortic cross-clamping (T2), 20 min after removal of the aortic cross-clamping (T3), and 10 min after separation from cardiopulmonary bypass (T4).Results: Demographic data were similar between the groups. Lactate level at the T2 period and CKMB levels during the study period were lower in Group D than in Group R. In both groups, all values except pyruvate significantly increased over time. Conclusion: The dexmedetomidine-sevoflurane combination may improve the cardioprotective effect in comparison with remifentanil-sevoflurane in CABG surgery.

Anahtar Kelimeler:

Dexmedetomidine, myocardial protection, remifentanil, sevoflurane

Tam Metin

Kaynak Göster

Bibtex	@ { tbtkmedical576366, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2017}, volume = {47}, pages = {1403 - 1409}, doi = {}, title = {Comparison of the cardioprotective effects of dexmedetomidineand remifentanil in cardiac surgery}, key = {cite}, author = {Türktan, Mediha and Güneş, Yasemin and Yalınız, Hafize and Matyar, Selçuk and Hatipoğlu, Zehra and Güleç, Ersel and Göçen, Uğur and Atalay, Atakan} }
APA	Türktan, M , Güneş, Y , Yalınız, H , Matyar, S , Hatipoğlu, Z , Güleç, E , Göçen, U , Atalay, A . (2017). Comparison of the cardioprotective effects of dexmedetomidineand remifentanil in cardiac surgery . Turkish Journal of Medical Sciences , 47 (5) , 1403-1409 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576366
MLA	Türktan, M , Güneş, Y , Yalınız, H , Matyar, S , Hatipoğlu, Z , Güleç, E , Göçen, U , Atalay, A . "Comparison of the cardioprotective effects of dexmedetomidineand remifentanil in cardiac surgery" . Turkish Journal of Medical Sciences 47 (2017 ): 1403-1409 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576366>
Chicago	Türktan, M , Güneş, Y , Yalınız, H , Matyar, S , Hatipoğlu, Z , Güleç, E , Göçen, U , Atalay, A . "Comparison of the cardioprotective effects of dexmedetomidineand remifentanil in cardiac surgery". Turkish Journal of Medical Sciences 47 (2017 ): 1403-1409
RIS	TY - JOUR T1 - Comparison of the cardioprotective effects of dexmedetomidineand remifentanil in cardiac surgery AU - Mediha Türktan , Yasemin Güneş , Hafize Yalınız , Selçuk Matyar , Zehra Hatipoğlu , Ersel Güleç , Uğur Göçen , Atakan Atalay Y1 - 2017 PY - 2017 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1403 EP - 1409 VL - 47 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote	%0 Turkish Journal of Medical Sciences Comparison of the cardioprotective effects of dexmedetomidineand remifentanil in cardiac surgery %A Mediha Türktan , Yasemin Güneş , Hafize Yalınız , Selçuk Matyar , Zehra Hatipoğlu , Ersel Güleç , Uğur Göçen , Atakan Atalay %T Comparison of the cardioprotective effects of dexmedetomidineand remifentanil in cardiac surgery %D 2017 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 47 %N 5 %R %U
ISNAD	Türktan, Mediha , Güneş, Yasemin , Yalınız, Hafize , Matyar, Selçuk , Hatipoğlu, Zehra , Güleç, Ersel , Göçen, Uğur , Atalay, Atakan . "Comparison of the cardioprotective effects of dexmedetomidineand remifentanil in cardiac surgery". Turkish Journal of Medical Sciences 47 / 5 (Ekim 2017): 1403-1409 .
AMA	Türktan M , Güneş Y , Yalınız H , Matyar S , Hatipoğlu Z , Güleç E , Göçen U , Atalay A . Comparison of the cardioprotective effects of dexmedetomidineand remifentanil in cardiac surgery. Turkish Journal of Medical Sciences. 2017; 47(5): 1403-1409.
Vancouver	Türktan M , Güneş Y , Yalınız H , Matyar S , Hatipoğlu Z , Güleç E , Göçen U , Atalay A . Comparison of the cardioprotective effects of dexmedetomidineand remifentanil in cardiac surgery. Turkish Journal of Medical Sciences. 2017; 47(5): 1403-1409.
IEEE	M. Türktan , Y. Güneş , H. Yalınız , S. Matyar , Z. Hatipoğlu , E. Güleç , U. Göçen ve A. Atalay , "Comparison of the cardioprotective effects of dexmedetomidineand remifentanil in cardiac surgery", Turkish Journal of Medical Sciences, c. 47, sayı. 5, ss. 1403-1409, Eki. 2017