İbrahim AYDIN,
Özden TURAN,
Fevzi Nuri AYDIN,
Esin KOÇ,
İbrahim Murat HİRFANOĞLU,
Mesut AKYOL,
Muzaffer ÖZTOSUN,
Emin Özgür AKGÜL,
Hilmi DEMİRİN,
Selim KILIÇ,
Mehmet Kemal ERBİL,
Taner ÖZGÜRTAŞ
2519
Comparing the fatty acid levels of preterm and term breast milk in Turkish women
Lipids are the main source of calories and considered very important in infant growth. We aimed to compare fatty acid composition of term and preterm breast milk. This is the first study that compares the fatty acid levels of preterm and term breast milk in Turkish women. Materials and methods: Breast milk samples were obtained from mothers of term (n = 15) and preterm (n = 15) infants on postnatal days 3, 7, and 28. Fatty acid composition of human breast milk was determined longitudinally by gas-chromatography/mass spectrometry. Results: There were 31 fatty acids measured in the milk samples. In the first month, 17 fatty acid levels had significant differences. In group comparison, some fatty acids (C14:0, C16:0, C18:1 and C20:5) had significantly increased in the preterm group (P = 0.041, P = 0.046, P = 0.027, P = 0.033, respectively), whereas myristoleic acid (C14:1) and eicosanoic acid (C20:0) had significantly increased in the term group (P = 0.015, P = 0.048, respectively). Conclusion: Term and preterm milk have different compositions of fatty acids. Breast milk composition changes over time. As a general conclusion, breast milk provides the lipid requirements of infants.
Comparing the fatty acid levels of preterm and term breast milk in Turkish women
Lipids are the main source of calories and considered very important in infant growth. We aimed to compare fatty acid composition of term and preterm breast milk. This is the first study that compares the fatty acid levels of preterm and term breast milk in Turkish women. Materials and methods: Breast milk samples were obtained from mothers of term (n = 15) and preterm (n = 15) infants on postnatal days 3, 7, and 28. Fatty acid composition of human breast milk was determined longitudinally by gas-chromatography/mass spectrometry. Results: There were 31 fatty acids measured in the milk samples. In the first month, 17 fatty acid levels had significant differences. In group comparison, some fatty acids (C14:0, C16:0, C18:1 and C20:5) had significantly increased in the preterm group (P = 0.041, P = 0.046, P = 0.027, P = 0.033, respectively), whereas myristoleic acid (C14:1) and eicosanoic acid (C20:0) had significantly increased in the term group (P = 0.015, P = 0.048, respectively). Conclusion: Term and preterm milk have different compositions of fatty acids. Breast milk composition changes over time. As a general conclusion, breast milk provides the lipid requirements of infants.
___
- ESPGAN Committee on Nutrition. Guidelines on infant nutrition. III. Recommendations for infant feeding. ACTA Pediatr Scand 1982; 302: 1–27.
- Mete E, Çatal F, Tayman C, Uras N, Akça H, Ulukanligil M, Özkaragöz F. Comparison of human milk, cow’s milk and infant formulas for their antifungal effects against environmental fungi. Turk J Med Sci 2009; 39: 67–72.
- Poston L, Phylactos A, Cunnane S, Schmidt W. The potential
- role for arachidonic and docosahexaenoic acids in protection
- against some central nervous system injuries in preterm
- infants. Lipids 2003; 38: 303–315. 7.
- Jensen RG. Lipids in human milk. Lipids 1999; 34: 1243–1271.
- Koletzko B, Decsi T. Role of long-chain polyunsaturated fatty acids in infant growth and development. In: Bendich A, Deckelbaum RJ, editors. Primary and Secondary Preventive Nutrition. Totowa, NJ, USA: Humana Press; 2001. pp. 237–252.
- Martin JC, Bougnoux P, Finon A, Theret V, Antoine JM, Lamisse F, Couet C. Dependence of human milk essential fatty acids on adipose stores during lactation. Am J Clin Nutr 1993; 58: 653–659.
- Rocquelin G, Tapsoba S, Dop MC, Mbemba F, Traissac P, Martin-Prével Y. Lipid content and essential fatty acid (EFA) composition of mature Congolese breast milk are influenced by mothers’ nutritional status: impact on infants’ EFA supply. Eur J Clin Nutr 1998; 52: 164–171.
- Spear LM, Hamosh M, Bitman J, Spear ML, Wood DL. Milk and blood fatty acid composition during two lactations in the same woman. Am J Clin Nutr 1992; 56: 65–70.
- Decsi T, Oláh S, Molnár S, Burus I. Fatty acid composition of human milk in Hungary. Acta Paediatr 2000; 89: 1394–1395.
- Büyüktuncer Z, Tosun BN, Ayaz A, Gezmen Karadağ G, Kocabaş Keser A, Aksoy M, Yurttagül M, Yücecan S, Besler HT. Implications of socio-economic status on the dietary fatty acid intakes in Turkish women. Turk J Med Sci 2010; 40: 305–312.
- Sauerwald TU, Demmelmair H, Koletzo B. Polyunsaturated fatty acid supply with human milk. Lipids 2001; 36: 991–996.
- VanderJagt DJ, Arndt CD, Okolo SN, Huang YS, Chuang LT, Glew RH. Fatty acid composition of the milk lipids of Fulani women and the serum phospholipids of their exclusively breast-fed infants. Early Human Development 2000; 60: 73–87.
- Molto-Puigmarti C, Castellote AI, Lopez-Sabater MC. Conjugated linoleic acid determination in human milk by fast- gas chromatography. Anal Chim Acta 2007; 602: 122–130.
- Decsi T, Koletzo B. Growth, fatty acid composition of plasma lipid classes, and plasma retinol and alpha-tocopherol concentrations in full-term infants fed formula enriched with w-6 and w-3 longchain polyunsaturated fatty acids. Acta Paediatr 1995; 84: 725–732.
- Fidler N, Koletzo B. The fatty acid composition of human colostrums. Eur J Nutr 2000; 39: 31–37.
- Fidler N, Salobir K, Stibilj V. Fatty acid composition of human milk in different regions of Slovenia. Ann Nutr Metab 2000; 44: 187–193.
- German JB, Dillard CJ. Saturated fats: a perspective from lactation and milk composition. Lipids 2010; 45: 915–923.
- German JB, Dillard CJ. Composition, structure and absorption of milk lipids: a source of energy, fat-soluble nutrients and bioactive molecules. Crit Rev Food Sci Nutr 2006; 46: 57–92.
- Kumbhat MM, Khanna SA, Bijur AM, Jadhav LS. Breast milk composition to gestation. Indian Pediat 1985; 22: 229–233.
- Paul VK, Singh M, Srivastava LM, Arora NK, Deorari AK. Macronutrient and energy content of breast milk of mothers delivering prematurely. Indian J Pediatr 1997; 64: 379–382.
- Gross SJ, Geller J, Tomarelli RM. Composition of breast milk from mothers of preterm infants. Pediatr 1981; 68: 490–493.
- Bitman J, Wood DL, Mehta NR, Hamosh P, Hamosh M. Comparison of the lipid composition of breast milk from mothers of term and preterm infants. Am J Clin Nutr 1983; 38: 300–312.
- Genczel-Boroviczeny O, Wahle J, Koletzko B. Fatty acid composition of human milk during the first month after term and preterm delivery. Eur J Pediatr 1997; 156: 142–147.
- Luukkainen P, Salo MK, Nikkai T. Changes in the fatty acid composition of preterm and term human milk from 1 week to 6 months of lactation. J Pediatr Gastroenterol Nutr 1994; 18: 355–360.
- Kovacs A, Funke S, Marosvölgyi T, Burus I, Decsi T. Fatty acids in early human milk after preterm and full-term delivery. J Pediatr Gastroenterol Nutr 2005; 41: 454–459.
- Birch DG, Birch EE, Hoffman DR, Uauy RD. Dietary essential fatty acid supply and visual acuity development. Invest Ophthalmol Visual Sci 1992; 33: 3242–3253.
- Innis SM. Essential fatty acids in growth and development, Prog Lipid Res 1991; 30: 39–103.
- Carlson SE, Rhodes PG, Ferguson MG. Docosahexaenoic acid status of preterm infants at birth and following feeding with human milk and formula. Am J Clin Nutr 1986; 44: 798–804.
- Birch EE, Birch DG, Hoffman DR, Uauy R. Retinal development in very low-birth-weight infants fed diets differing in omega-3 fatty acids. Invest Ophthalmol Visual Sci 1992; 33: 2365–2376.
- Tonbul A, Tayman C, Karadağ A, Akça H, Uras N, Tatlı MM. Small-for-gestational-age newborns need a special fluid therapy strategy. Turk J Med Sci 2010; 40: 185–190.
- Uauy R, Hoffman DR. Essential fat requirements of preterm infants. Am J Clin Nutr 2000; 71: 245–250.
- Koletzko B, Thiel I, Abiodun PO. The fatty acid composition of human milk in Europe and Africa. J Pediatr 1992; 120: 62–70.
- Hamosh M, Henderson TR, Kemper MA, Orr NM, Gil A, Hamosh P. Long-chain polyunsaturated fatty acids (LC-PUFA) during early development: contribution of milk LC-PUFA to accretion rates varies among organs. Adv Exp Med Biol 2001; 501: 397–401.
- Jensen CL, Heird WC. Lipids with an emphasis on long-chain polyunsaturated fatty acids. Clin Perinatol 2002; 29: 261–281.
- Ozgurtas T, Aydin I, Turan O, Koc E, Hirfanoglu IM, Acikel CH, Akyol M, Serdar M, Erbil KM. Soluble vascular endothelial growth factor receptor-1 in human breast milk. Horm Res Paediatr 2011; 76: 17–21.
- Ozgurtas T, Aydin I, Turan O, Koc E, Hirfanoglu IM, Acikel CH, Akyol M, Erbil MK. Vascular endothelial growth factor, basic fibroblast growth factor, insulin-like growth factor-I and platelet-derived growth factor levels in human milk of mothers with term and preterm neonates. Cytokine 2010; 50: 192–194.
- Aydın İ, Özgurtaş T, Turan Ö, Koç E, Hırfanoğlu İM, Açıkel C, Garipoğlu G, Akyol M, Tunç T, Erbil MK. Biochemical comparison of preterm and term newborn’s mother’s milk. Turk J Biochem 2009; 34: 242–249.