Clinical appearance of brucellosis in adults: fourteen years of experience

To indicate the clinical course and results of brucellosis in our region during the recent years, and to compare these findings to the literature. Materials and methods: This study was based on a review of the medical records of adult patients older than 14 years who were followed with the diagnosis of brucellosis from March 1997 to October 2010. Results: Included in this analysis were 317 patients, including 136 males (43%), with an average age of 40 ± 17 years. In 66 patients (21%), reproduction of Brucella was identified in the blood. Of the patients, 61% were identified as having the acute form, 35% the subacute form, and 4% the chronic form. Arthralgia, fever, weight loss, sacroiliitis, and spondylitis were the most frequent symptoms and findings accompanying the disease. There was a significant relationship between advanced age and the development of both spondylitis and arthritis (P = 0.000 and P = 0.028, respectively). Furthermore, there was a significant relationship between a high erythrocyte sedimentation rate and the presence of spondylitis, sacroiliitis, and visceral abscesses (P = 0.001, P = 0.013, and P = 0.049, respectively). Conclusion: This study provides a review of the disease and its complications. Osteoarticular involvement, and particularly the presence of spondylitis in patients and the complications in elderly patients, should be studied. Laboratory parameters, the patient's age, and the duration of symptoms may help to identify complicated cases.

Clinical appearance of brucellosis in adults: fourteen years of experience

To indicate the clinical course and results of brucellosis in our region during the recent years, and to compare these findings to the literature. Materials and methods: This study was based on a review of the medical records of adult patients older than 14 years who were followed with the diagnosis of brucellosis from March 1997 to October 2010. Results: Included in this analysis were 317 patients, including 136 males (43%), with an average age of 40 ± 17 years. In 66 patients (21%), reproduction of Brucella was identified in the blood. Of the patients, 61% were identified as having the acute form, 35% the subacute form, and 4% the chronic form. Arthralgia, fever, weight loss, sacroiliitis, and spondylitis were the most frequent symptoms and findings accompanying the disease. There was a significant relationship between advanced age and the development of both spondylitis and arthritis (P = 0.000 and P = 0.028, respectively). Furthermore, there was a significant relationship between a high erythrocyte sedimentation rate and the presence of spondylitis, sacroiliitis, and visceral abscesses (P = 0.001, P = 0.013, and P = 0.049, respectively). Conclusion: This study provides a review of the disease and its complications. Osteoarticular involvement, and particularly the presence of spondylitis in patients and the complications in elderly patients, should be studied. Laboratory parameters, the patient's age, and the duration of symptoms may help to identify complicated cases.

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  • Gür A, Geyik MF, Dikici B, Nas K, Çevik R, Saraç J et al.
  • Complications of brucellosis in diff erent age groups: a study
  • of 283 cases in Southeastern Anatolia of Turkey. Yonsei Med J 2003; 44: 33-44.
  • Aygen B, Doğanay M, Sümerkan B, Yildiz O, Kayabaş Ü. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Mal Infect 2002; 32: 485-93.
  • Savas L, Onlen Y, Savas N, Yapar AF, Aydin M, Onder T. Prospective evaluation of 140 patients with brucellosis in the southern region of Turkey. Infect Dis Clin Pract 2007; 15: 83-8.
  • Demiroğlu YZ, Turunç T, Alışkan H, Çolakoğlu S, Arslan H. Brucellosis: retrospective evaluation of the clinical, laboratory and epidemiological features in 151 cases. Mikrobiyol Bül 2007; 41: 517-27.
  • Akdeniz H, Irmak H, Demiroz AP. Evaluation of brucellosis cases in Van region of Eastern Anatolia: a 3-year experience. Nagoya Med J 1998; 42: 101-10.
  • Kokoglu OF, Hosoglu S, Geyik MF, Ayaz C, Akalın S, Buyukbese MA et al. Clinical and laboratory features of brucellosis in two university hospitals in southeast Turkey. Trop Doct 2006; 36: 49-51.
  • Lulu AR, Araj GF, Khateeb MI, Mustafa MY, Yusuf AR, Fenech FF. Human brucellosis in Kuwait: a prospective study of 400 cases. Q J Med 1988; 66: 39-54.
  • Mantur BG, Biradar MS, Bidri RC, Mulimani MS, Veerappa, Kariholu P et al. Protean clinical manifestations and diagnostic challenges of human brucellosis in adults: 16 years’ experience in an endemic area. J Med Microbiol 2006; 55: 897-903.
  • Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O et al. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. International Journal of Infectious Diseases 2010; 14: 469-78.
  • Kurtaran B, Tunay S, Tasova Y, Candevir A, Saltoglu N, Inal AS et al. Brucellar and tuberculous spondylitis in 87 adult patients: a descriptive and comparative case series. Infect Dis Clin Practice 2008; 16: 166-73.
  • Cordero M, Sanchez Y. Brucellar and tuberculous spondylitis: a comparative study of their clinical features. J Bone Joint Surg Br 1991; 73: 100-3.
  • Colmenero JD, Jimenez-Mejias ME, Sanchez-Lora FJ, Reguera JM, Palomino-Nicás J, Martos F et al. Pyogenic, tuberculous, and brucellar vertebral osteomyelitis: a descriptive and comparative study of 219 cases. Ann Rheum Dis 1997; 56: 709- 15.
  • Colmonero JD, Reguera JM, Fernandez-Nebro A, Cabrera- Franquelo F. Osteoarticular complications of brucellosis. Ann Rheum Dis 1991; 50: 23-6.
  • Gotuzzo E, Alarcon GS, Bocanegra TS, Carrillo C, Guerra JC, Rolando I et al. Articular involvement in human brucellosis: a prospective analysis of 304 cases. Semin Arthritis Rheum 1982; 12: 245-55.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
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Clinical appearance of brucellosis in adults: fourteen years of experience

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