Erol COŞKUN, Seydi OKUMUŞ, Bülent GÜRLER, Ramazan YAYUSPAYI, Burak ÖREN, Erdal KAYDU, Ayşegül ÇÖMEZ, İbrahim ERBAĞCI

Choroidal thickness in healthy Turkish subjects

To investigate choroidal thickness in healthy Turkish subjects. Materials and methods: Refraction, axial length (AXL) measurement, anterior chamber, and fundus examinations were performed. Eyes that had any retinal or choroidal pathology were excluded from the study. Enhanced-depth imaging optical coherence tomography was used to evaluate choroidal thickness. Results: 139 eyes from 70 subjects were investigated. The mean age, AXL, spherical equivalent refractive error (SE), and subfoveal choroidal thickness (SCT) were 34.7 ± 12.7 years, 23.31 ± 0.91 mm, -0.15 ± 1.64 diopters (D), and 326 ± 60 µm, respectively. A negative correlation was found between SCT and AXL (P = 0.043). The mean age, SE, AXL, and SCT were 31.7 ± 9.3 and 34.6 ± 14.3 years, -0.27 ± 1.45 and 0.02 ± 1.89 D, 23.52 ± 0.94 and 23.02 ± 0.75 mm, and 324 ± 69 and 329 ± 40 µm in male and female subjects, respectively (P = 0.14, P = 0.31, P = 0.001, and P = 0.58, respectively). Regression analysis showed that SCT decreased by 0.93 µm for each year of age. Conclusion: In healthy Turkish subjects, SCT decreased by 0.93 µm for each year of age and was thicker in men when the results were adjusted according to AXL measurements.

Anahtar Kelimeler:

Key words: Choroidal thickness, EDI OCT

Choroidal thickness in healthy Turkish subjects

Keywords:

Key words: Choroidal thickness, EDI OCT,

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Wangsa-Wirawan ND, Linsenmeier RA. Retinal oxygen: fundamental and clinical aspects. Arch Ophthalmol 2003; 121: 547–57.
Yu DY, Cringle SJ. Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease. Prog Retin Eye Res 2001; 20: 175–208.
Reiner A, Del Mar N, Zagvazdin Y, Li C, Fitzgerald ME. Agerelated impairment in choroidal blood flow compensation for arterial blood pressure fluctuation in pigeons. Invest Ophthalmol Vis Sci 2011; 52: 7238–47.
De Moraes CG, Reis AS, Cavalcante AF, Sano ME, Susanna R Jr. Choroidal expansion during the water drinking test. Graefes Arch Clin Exp Ophthalmol 2009; 247: 385–9.
Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol 2009; 147: 811–5.
Ikuno Y, Kawaguchi K, Nouchi T, Yasuno Y. Choroidal thickness in healthy Japanese subjects. Invest Ophthalmol Vis Sci 2010; 51: 2173–6.
Li XQ, Larsen M, Munch IC. Subfoveal choroidal thickness in relation to sex and axial length in 93 Danish university students. Invest Ophthalmol Vis Sci 2011; 52: 8438–41.
Imamura Y, Fujiwara T, Margolis R, Spaide RF. Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy. Retina 2009; 29: 1469–73.
Jirarattanasopa P, Ooto S, Nakata I, Tsujikawa A, Yamashiro K, Oishi A et al. Choroidal thickness, vascular hyperpermeability, and complement factor H in age-related macular degeneration and polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci 2012; 53: 3663–72.
Park SC, De Moraes CG, Teng CC, Tello C, Liebmann JM, Ritch R. Enhanced depth imaging optical coherence tomography of deep optic nerve complex structures in glaucoma. Ophthalmology 2012; 119: 3–9.
Grossniklaus HE, Green WR. Choroidal neovascularization. Am J Ophthalmol 2004; 137: 496–503.
Gomi F, Tano Y. Polypoidal choroidal vasculopathy and treatments. Curr Opin Ophthalmol 2008; 19: 208–12.
Spaide RF, Hall L, Haas A, Campeas L, Yannuzzi LA, Fisher YL et al. Indocyanine green videoangiography of older patients with central serous chorioretinopathy. Retina 1996; 16: 203–13.
Kim YM, Yoon JU, Koh HJ. The analysis of lacquer crack in the assessment of myopic choroidal neovascularization. Eye 2011; 25: 937–46.
Dündar S, Özcura F, Meteoğlu İ, Kara ME. Effects of long-term passive smoking on the vascular endothelial growth factor and apoptosis marker expression in the retina and choroid: an experimental study. Turk J Med Sci 2012; 42: 377–83.
Mori K, Horie-Inoue K, Gehlbach PL, Takita H, Kabasawa S, Kawasaki I et al. Phenotype and genotype characteristics of age-related macular degeneration in a Japanese population. Ophthalmology 2010; 117: 928–38.
Klein R, Klein BE, Knudtson MD, Wong TY, Cotch MF, Liu K et al. Prevalence of age-related macular degeneration in 4 racial/ ethnic groups in the multi-ethnic study of atherosclerosis. Ophthalmology 2006; 113: 373–80.
Giddabasappa A, Bauler M, Yepuru M, Chaum E, Dalton JT, Eswaraka J. 17-β estradiol protects ARPE-19 cells from oxidative stress through estrogen receptor-β. Invest Ophthalmol Vis Sci 2010; 51: 5278–87.
Zhang HB, Sun NX, Liang HC, Xiao XH, Liu XN, Wang YN. 17-Alpha-estradiol ameliorating oxygen-induced retinopathy in a murine model. Jpn J Ophthalmol 2012; 56: 407–15.
Snow KK, Cote J, Yang W, Davis NJ, Seddon JM. Association between reproductive and hormonal factors and age-related maculopathy in postmenopausal women. Am J Ophthalmol 2002; 134: 842–8.
Seitzman RL, Mangione C, Ensrud KE, Cauley JA, Stone KL, Cummings SR et al. Postmenopausal hormone therapy and age-related maculopathy in older women. Ophthalmic Epidemiol 2008; 15: 308–16.
Owen CG, Jarrar Z, Wormald R, Cook DG, Fletcher AE, Rudnicka AR. The estimated prevalence and incidence of late stage age related macular degeneration in the UK. Br J Ophthalmol 2012; 96: 752–6.