Yasemin YULAF, Cem ÇELİK, Burçin NALBANTOĞLU, Ayşin NALBANTOĞLU, Aysun BİDECİ, Hamdi Cihan EMEKSİZ, Mahmut Orhun ÇAMURDAN, Peyami CİNAZ

Anxiety and depression states of adolescents with polycystic ovary syndrome

Background/aim: Various studies have shown that adult patients with polycystic ovary syndrome (PCOS) have higher levels of anxietyand depression compared to their normal counterparts. However, it is still unclear whether these mood disorders already exist inadolescents affected by PCOS. The aim of the present study is to assess differences in anxiety and depression levels between adolescentswith PCOS and age- and body mass index (BMI)-matched controls and to determine the possible factor(s) impacting these psychologicalparameters in adolescents with PCOS.Materials and methods: The study included 80 adolescents with PCOS and 50 age- and BMI-matched controls. All participantscompleted standardized questionnaires assessing anxiety and depression. A multiple linear regression model was used to analyze theimpact of potential variables on anxiety and depression scores of the adolescents with PCOS.Results: Significantly higher levels of anxiety, specifically generalized and social anxieties, as well as depression were found in adolescentswith PCOS compared to controls. Higher BMI was found to be associated with higher levels of depression and generalized anxiety, andhigher modified Ferriman–Gallwey score with higher level of panic disorder in adolescents affected by PCOS.Conclusion: Adolescents with PCOS experience significantly more emotional distress compared to adolescents without PCOS. Thisemotional distress may be related, at least in part, to certain clinical features of PCOS including obesity and hirsutism. PCOS inadolescents should be assessed not only for the gynecological and metabolic aspects but also for the emotional aspects of the disease.

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