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• 1. Proctor RN. The history of the discovery of the cigarette–lung cancer link: evidentiary traditions, corporate denial, global toll. Tob Control 2012; 21: 87–91.
• 2. Ezzati M, Lopez AD. Estimates of global mortality attributable to smoking in 2000. Lancet 2003; 362: 847–852.
• 3. Wynder EL, Stellman SD. Impact of long-term filter cigarette usage on lung and larynx cancer risk: a case-control study. J Natl Cancer Inst 1979; 62: 471–477.
• 4. Doll R. Cancers weakly related to smoking. Br Med Bull 1996; 52: 35–49.
• 5. Davis R, Rizwani W, Banerjee S, Kovacs M, Haura E, Coppola D,  Chellappan S. Nicotine promotes tumor growth and metastasis in mouse models of lung cancer. PloS One 2009; 4: e7524.
• 6. Christianson RE. The relationship between maternal smoking and the incidence of congenital anomalies. Am J Epidemiol 1980; 112: 684–695.
• 7. Stillman RJ,  Rosenberg MJ,  Sachs BP. Smoking and reproduction. Fertil Steril 1986; 46: 545–566.
• 8. Källén K. Multiple malformations and maternal smoking. Paediatr Perinat Epidemiol 2000; 14: 227–233.
• 9. Zhao Z, Reece EA. Nicotine-induced embryonic malformations mediated by apoptosis from increasing intracellular calcium and oxidative stress. Birth Defects Res B Dev Reprod Toxicol 2005; 74: 383–391.
• 10. Suarez L,  Felkner M,  Brender JD,  Canfield M,  Hendricks K. Maternal exposures to cigarette smoke, alcohol, and street drugs and neural tube defect occurrence in offspring. Matern Child Health J 2008; 12: 394–401.
• 11. Dalgiç A,  Armağan E,  Helvacioğlu F,  Okay O,  Dağlioğlu E, Take G, Unlü A, Belen D. High dose cotinine may induce neural tube defects in a chick embryo model. Turk Neurosurg 2009; 19: 224–229.
• 12. Alexander PG,  Tuan RS. Carbon monoxide-induced axial skeletal dysmorphogenesis in the chick embryo. Birth Defects Res A Clin Mol Teratol 2003; 67: 219–230.
• 13. Pryor WA, Stone K. Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrite, and peroxynitrite. Ann N Y Acad Sci 1993; 686: 12–27.
• 14. Hukkanen J,  Jacob P 3rd,  Benowitz NL. Metabolism and disposition kinetics of nicotine. Pharmacol Rev 2005; 57: 79– 115.
• 15. Yildiz D. Nicotine, its metabolism and an overview of its biological effects. Toxicon 2004; 43: 619–632.
• 16. Florek E, Janicki R, Piekoszewski W, Kulza M, Chuchracki M, Sedziak A. Tobacco smoking influence on the level of sex hormones--animal model. Przegl Lek 2008; 65: 508–513 (article in Polish with an abstract in English). 
• 17. Kavitharaj NK,  Vijayammal PL. Nicotine administration induced changes in the gonadal functions in male rats. Pharmacology 1999; 58: 2–7.
• 18. Mailhes JB, Young D, Caldito G, London SN. Sensitivity of mouse oocytes to  nicotine-induced perturbations during oocyte meiotic maturation and aneuploidy in vivo and in vitro. Mol Hum Reprod 2000; 6: 232–237.
• 19. Husain K, Scott BR, Reddy SK, Somani SM. Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system. Alcohol 2001; 25: 89–97.
• 20. Kelly F. Oxidative stress: its role in air pollution and adverse health effects. Occup Environ Med 2003; 60: 612–616.
• 21. Ermak G, Davies KJ. Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol 2002; 38: 713–721.
• 22. Turner TT,  Lysiak JJ. Oxidative stress: a common factor in testicular dysfunction. J Androl 2008; 29: 488–498.
• 23. Sofikitis N, Miyagawa I, Dimitriadis D, Zavos P, Sikka  S, Hellstrom W. Effects of smoking on testicular function, semen quality and sperm fertilizing capacity. J Urol 1995; 154: 1030–1034.
• 24. Reddy S, Londonkar R, Ravindra, Reddy S, Patil SB. Testicular changes due to graded doses of nicotine in albino mice. Indian J Physiol Pharmacol 1998; 42: 276–280.
• 25. Yamamoto Y,  Isoyama E,  Sofikitis N,  Miyagawa I. Effects of smoking on testicular function and fertilizing potential in rats. Urol Res 1998; 26: 45–48.
• 26. Rajpurkar A,  Li H,  Dhabuwala CB. Morphometric analysis of rat testis following chronic exposure to cigarette smoke. J Environ Pathol Toxicol Oncol 2000; 19: 363–368.
• 27. Aydos K, Güven MC, Can B, Ergün A. Nicotine toxicity to the ultrastructure of the testis in rats. BJU Int 2001; 88: 622-626.
• 28. Ahmadnia H,  Ghanbari M,  Moradi MR,  Khaje-Dalouee M. Effect of cigarette smoke on spermatogenesis in rats. Urol J 2007; 4: 159–163.
• 29. Cocuzza M,  Sikka SC,  Athayde KS,  Agarwal A. Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis. Int Braz J Urol 2007; 33: 603–621.
• 30. Araújo CC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz 2001; 96: 723–728.
• 31. Bengmark S, Mesa MD, Gil A. Plant-derived health: the effects of turmeric and curcuminoids. Nutr Hosp 2009; 24: 273–281.
• 32. Sharma RA, Gescher AJ, Steward WP. Curcumin: the story so far. Eur J Cancer 2005; 41: 1955–1968.
• 33. Duvoix A, Blasius R, Delhalle S, Schnekenburger M, Morceau F,  Henry E,  Dicato M,  Diederich M. Chemopreventive and therapeutic effects of curcumin. Cancer Lett 2005; 223: 181– 190.
• 34. Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sci 2006; 78: 2081–2087.
• 35. Aggarwal BB,  Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 2009; 41: 40–59.
• 36. Kalpana C,  Menon VP. Modulatory effects of curcumin on lipid peroxidation and antioxidant status during nicotineinduced toxicity. Pol J Pharmacol 2004; 56: 581–586.
• 37. Kalpana C,  Sudheer AR,  Rajasekharan KN,  Menon VP. Comparative effects of curcumin and its synthetic analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med J 2007; 48: 124–130.
• 38. Farombi EO,  Abarikwu SO,  Adedara IA,  Oyeyemi MO. Curcumin and kolaviron ameliorate di-n-butylphthalateinduced testicular damage in rats. Basic Clin Pharmacol Toxicol 2007; 100: 43–48.
• 39. Giannessi F, Giambelluca MA, Grasso L, Scavuzzo MC, Ruffoli R. Curcumin protects Leydig cells of mice from damage induced by chronic alcohol administration. Med Sci Monit 2008; 14: BR237–BR242.
• 40. Sahoo DK, Roy A, Chainy GB. Protective effects of vitamin E and curcumin on L-thyroxine-induced rat testicular oxidative stress. Chem Biol Interact 2008; 176: 121–128.
• 41. El-Demerdash FM,  Yousef MI,  Radwan FM. Ameliorating effect of curcumin on sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs. Food Chem Toxicol 2009; 47: 249–254.
• 42. Ilbey YO,  Ozbek E,  Cekmen M,  Simsek A,  Otunctemur A, Somay A. Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways. Hum Reprod 2009; 24: 1717–1725.
• 43. Sharma P,  Singh R. Protective role of curcumin on lindane induced reproductive toxicity in male Wistar rats. Bull Environ Contam Toxicol 2010; 84: 378–384.
• 44. Aktas C, Kanter M, Erboga M, Ozturk S. Anti-apoptotic effects of  curcumin  on cadmium-induced apoptosis in rat testes. Toxicol Ind Health 2012; 28: 122–130.
• 45. Khorsandi L,  Mirhoseini M,  Mohamadpour M,  Orazizadeh M, Khaghani S. Effect of curcumin on dexamethasone-induced testicular toxicity in mice. Pharm Biol 2013; 51: 206–212.
• 46. El-Wakf AM, Elhabiby EM, El-kholy WM, Abd El-Ghany E. Use of tumeric and curcumin to alleviate adverse reproductive outcomes of water nitrate pollution in male rats. Nature and Science 2011; 9: 229–239.
• 47. Johnsen SG. Testicular biopsy score count–a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones 1970; 1: 2–25.
• 48. Peltola V,  Huhtaniemi I,  Ahotupa M. Antioxidant enzyme activity in the maturing rat testis. J Androl 1992; 13: 450–455.
• 49. Park EM, Park YM, Gwak YS. Oxidative damage in tissues of rats exposed to cigarette smoke. Free Radic Biol Med 1998; 25: 79–86.
• 50. Aitken RJ, Roman SD. Antioxidant systems and oxidative stress in the testes. Oxid Med Cell Longev 2008; 1: 15–24.
• 51. Al-Bader A, Omu AE, Dashti H. Chronic cadmium toxicity to sperm of heavy cigarette smokers: immunomodulation by zinc. Arch Androl 1999; 43: 135–140.
• 52. Jana K,  Samanta PK,  De DK. Nicotine diminishes testicular gametogenesis, steroidogenesis, and steroidogenic acute regulatory protein expression in adult albino rats: possible influence on pituitary gonadotropins and alteration of testicular antioxidant status. Toxicol Sci 2010; 116: 647–659.
• 53. Ray G, Husain SA. Oxidants, antioxidants and carcinogenesis. Indian J Exp Biol 2002; 40: 1213–1232.
• 54. Verma RJ,  Mathuria N. Effect of curcumin on aflatoxininduced biochemical changes in testis of mice. Fertil Steril 2009; 91: 597–601.
• 55. Abarikwu SO, Akiri OF, Durojaiye MA, Alabi AF. Combined administration of  curcumin  and gallic acid inhibits gallic acid-induced suppression of steroidogenesis, sperm output, antioxidant defenses and inflammatory responsive genes. J Steroid Biochem Mol Biol 2014; 143: 49–60.
• 56. Güven MC, Can B, Ergün A, Saran Y, Aydos K. Ultrastructural effects of cigarette smoke on rat testis. Eur Urol 1999; 36: 645– 649.
• 57. Sepaniak S, Forges T, Gerard H, Foliguet B, Bene MC, MonnierBarbarino P. The influence of cigarette smoking on human sperm quality and DNA fragmentation. Toxicology 2006; 223: 54–60.