Background/aim: The aim of this study was to cross-culturally adapt the Turkish version of the Patient-Rated Wrist/Hand Evaluation (T-PRWHE) questionnaire for use in the Turkish patient population. Moreover, we aimed to evaluate the reliability and validity of the T-PRWHE questionnaire. Materials and methods: A total of 166 patients with hand and wrist problems were included in the study. They completed the T-PRWHE, the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire, and the 36-Item Short-Form Health Survey (SF-36) at baseline and at the 3rd month of the study. Reliability was evaluated by analyzing internal consistency (Cronbach alpha coefficient) and test-retest reliability (intraclass correlation coefficient). To analyze validity, factor analysis of the T-PRWHE and correlation coefficients between the T-PRWHE, DASH, and SF-36 were obtained.Results: Reliability of the T-PRWHE in terms of internal consistency (Cronbach alpha coefficients for T-PRWHE were found to be 0.85) was excellent. Intraclass correlation coefficients were over 0.90. The T-PRWHE has three factors and the correlations between the T-PRWHE and DASH and SF-36 were statistically significant.Conclusion: Based on the results obtained, the Turkish version of the PRWHE questionnaire was found to be a valid and reliable scale and it is recommended for the evaluation of patient-based pain and disability level in routine clinical practice.