The Tutte polynomial is a two-variable polynomial that is connected by a graph, a matroid or a matrix.The Tutte polynomial has a lot of exciting applications in different areas for example combinatorics, probability,knot theory, algebra, statistical mechanics, computer sciences, chemistry and biology. It was indicated by W. T.Tutte. We transport the Tutte polynomial to knot theory. Because each knot have a corresponding graph. Westudy the Tutte polynomial for graphs of twist knots. We find some general forms for the Tutte polynomial ofgraphs belonging to twist knots and the Tutte polynomial of signed graphs belonging to twist knots. Twist knotsare significant class of knots to take into account especially in contact geometry.