Effect of endurance training on plasma levels of AGRP and HOMA-IR in diabetic rats
Effect of endurance training on plasma levels of AGRP and HOMA-IR in diabetic rats
The hypothalamus is a strong central controller of appetite that secretes different neuropeptides including AGRP. Plasma levels of AGRP are effective in controlling obesity and hunger. Therefore, the current study was performed with the aim of investigating the effect of endurance training on plasma levels of AGRP and HOMA-IR in diabetic rats. The Current study was experimental by posttest and control group. Eighteen male Wistar rats (200-220 grams with 8-10 weeks) were randomly divided into the control group and diabetic training. Eight weeks endurance training program included in the group of animal diabetic training for 5 days per week (15-40) minutes at 50 to 65 percent of vo2max. To determine the serum concentrations of AGRP was used by ELISA. A comparison of two groups showed significantly increased plasma concentrations of AGRP (p=0.006) and insulin resistance index, decreased significantly (p=0.002) compared to the control group after eight weeks, endurance training. According to the results, increased plasma concentrations of AGRP can be attributed to the negative balance caused by training. This agent destroys the body's energy balance and hypothalamus for balancing increases the secretion of AGRP. This neuropeptide is likely will cause higher fat metabolism.
Keywords:
Agouti-related protein, endurance training, insulin resistance, diabetes,
___
- Abdi A, Abbasi A. The response of Agouti-Related Protein (AGRP) after a single session of aebobic training in untrained men. Journal of Sports Medicine and Physical Fitness, 2014; 1(2): 37-46.
- Chen HY, Trumbauer ME, Chen AS, Weingarth DT, Adams JR, Frazier EG, Shen Z, Marsh DJ, Feighner SD, Guan XM, Ye Z, Nargund RP, Smith RG, Van der Ploeg LH, Howard AD, MacNeil DJ, Qian S. Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology, 2004; 145(6): 2607-2612.
- Gorgisen G, Balci MK, Celik FC, Ozes ON. Differential actıvation and expression of insulin receptor substrate 1 (IRS1) in mononuclear cells of type 2 diabetes patients after insulin stimulation. Cellular and molecular biology (Noisy-le-Grand, France), 2015; 62(2): 25-30.
- Hosseini-Khakhak SA, Ghanbari Niaki A, Rahbarizadeh F, Mohagheghi MA, Khabazian BM, Fathi R, Hedayati M. The effect of treadmill running on plasma and muscle agouti-related protein (AGRP) concentration in male rats. Iranian Journal of Endocrinology and Metabolism, 2009; 11(4): 455-461.
- Ilnytska O, Argyropoulos G. The role of the Agouti-Related Protein in energy balance regulation. Cellular and molecular life sciences, 2008; 65(17): 2721.
- Levin BE, Dunn-Meynell AA. Chronic exercise lowers the defended body weight gain and adiposity in diet-induced obese rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2004; 286(4): R771-R778.
- Lin CY, Higginbotham DA, Judd RL, White BD. Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats. American Journal of Physiology-Endocrinology and Metabolism, 2002; 282(5): E1084-E1091.
- Luzi L. Cellular Physiology and Metabolism of Physical Exercise, 2012.
- Ma X, Zubcevic L, Ashcroft FM. Glucose regulates the effects of leptin on hypothalamic POMC neurons. Proceedings of the National Academy of Sciences, 2008; 105(28): 9811-9816.
- Rashidlamir A, Ghanbari-niaki A. Effect of 8-week circuit training on lymphocyte AGRP gene expression in well-trained wrestlers. Daneshvar, 2010; 18(89): 67-72.
- Santer R, Klepper J. Disorders of glucose transport, in Inborn metabolic diseases. Springer, 2016.
- Shrestha YB, Wickwire K, Giraudo SQ. Role of AgRp on Ghrelin-induced feeding in the hypothalamic paraventricular nucleus. Regulatory Peptides, 2006; 133(1): 68-73.
- Stenlöf K, Cefalu WT, Kim KA, Alba M, Usiskin K, Tong C, Canovatchel W, Meininger G. Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise. Diabetes, Obesity and Metabolism, 2013; 15(4): 372-382.
- Sternson SM, Atasoy D. Agouti-related protein neuron circuits that regulate appetite. Neuroendocrinology, 2014; 100(2-3): 95-102.
- Woods SC, Benoit SC, Clegg DJ, Seeley RJ. Regulation of energy homeostasis by peripheral signals. Best Practice & Research Clinical Endocrinology & Metabolism, 2004; 18(4): 497-515.
- World Diabetes Congress. http://www.vancouver conventioncentre.com/events/world-diabetes-congress-2015.
- Başlangıç: 2015
- Yayıncı: Nurtekin Erkmen
Sayıdaki Diğer Makaleler
Drew RYKERT, Chad HARRİS, Kent J. ADAMS, Mark DEBELİSO
Profile injuries and musculoskeletal abnormalities of elite wushu athletes
Mohammad Reza CHANGİZİ, Nader RAHNAMA
Effect of endurance training on plasma levels of AGRP and HOMA-IR in diabetic rats
Javad MEHRABANİ, Maryam SEDİGHİANRAD, Nasrin RAMEZANİ, Hadi NOBARİ, Reza BAGHERİ