Hüsamettin Vatansev, Sedat Abuşoğlu, Ali Ünlü, Esra Paydaş Hataysal, Beyza Saraçlıgil

Sağlıklı Yetişkinlerde D Vitamini Eksikliği Prevalansı

Amaç: D vitamini, birçok metabolik yolakta rol alan ve bazı hastalıklarla ilişkili olan bir hormondur. Vitamin D fizyolojisi çok karmaşıktır. Etnik köken, yaş, cinsiyet, hastalıklar ve ilaç kullanımı vitamin D konsantrasyonunu etkilemektedir. Bu çalışmada amacımız Türkiye’de sağlıklı erişkinlerde vitamin D eksikliği sıklığını belirlemekti. Yöntem: 2015-2016 yılları arasında Selçuk Üniversitesi Tıp Fakültesi Hastanesi'ne başvuran 2007 hastanın 25(OH)D3 test sonuçları retrospektif olarak incelendi. Vitamin D içeren ilaç kullanan, kronik hastalık veya enflamatuar hastalıkları olan hastalar çalışma dışı bırakılmıştır. D vitamini seviyeleri, 25(OH)D3 ölçmek için altın standart olan kromatografik yöntemle (LC / MS / MS) API3200 cihazı ile ölçülmüştür. Sonuçlar: Bulgularımız, çalışma popülasyonumuzda D vitamini eksikliği prevalansının yaklaşık %67,9 olduğunu göstermektedir. D vitamini ortalama değeri 16,87 ng/mL idi ve kadınlarda 25(OH)D3 seviyeleri, erkeklere göre anlamlı derecede düşüktü (p

Prevalence of Vitamin D Deficiency in Healthy Adults

Objectives: Vitamin D is a well-known hormone and important for many metabolic pathways and different health outcomes. Thephysiology of vitamin D is very complex. Multiple factors like ethnicity, age, sex, diseases, and medication influence vitamin Dconcentrations. In this study, our aim was to determine the prevalence of vitamin D deficiency among adults in Turkey. Materialmethods: The 25(OH) vitD3 test results of 2007 patients admitted to Selçuk University Medicine Faculty hospital between the yearsof 2015 and 2016 were analyzed, retrospectively. Patients using any vitamin D consisting drug, having chronic disease andinflammatory disorders were excluded. Vitamin D levels were measured by a chromatographic method (LC/MS/MS) with API3200which is the gold standard to measure 25(OH)D3. Results: Our results show that the prevalence of vitamin D deficiency is about67.9% in our society. The mean value of vitamin D was 16,87 ng/mL and females had significantly lower 25(OH)D3 levels comparedto males (p

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1. Heaney RP, Dowell MS, Hale CA, Bendich A. Calcium absorption varies within the reference range for serum 25- hydroxyvitamin D. J Am Coll Nutr 2003;22:142-146.
2. Wacker M, Holick MF. Sunlight and vitamin D: a global perspective for health. Dermato-Endocrinol. 2013;5(1):51–108.
3. Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord (2017) 18:153–165 DOI 10.1007/s11154-017-9424-1
4. Altieri B, Muscogiuri G, Barrea L, Mathieu C, Vallone CV, Mascitelli L et al. Rev Endocr Metab Disord. Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept. (2017) Sep;18(3):335- 346. doi: 10.1007/s11154-016-9405-9.
5. Battault S, Whiting SJ, Peltier SL, Sadrin S, Gerber G, Maixent JM. Vitamin D metabolism, functions, and needs: from science to health claims. Eur J Nutr (2013) 52:429–441 DOI 10.1007/s00394-012-0430- 5
6. Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014 October; 144PA: 138–145. doi:10.1016/j.jsbmb.2013.11.003
7. Daly RM, Gagnon C, Lu ZX, et al. Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older: a national, population-based study. Clin Endocrinol. 2012; 77:26–35.
8. Antico A, Tampoia M, Tozzoli R, Bizzaro N. Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature. Autoimmun Rev 2012; 12:127-36; PMID:22776787; http://dx.doi.org/10.1016/j.autrev.2012.07.0 07
9. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357:266–81.
10. Granlund L, Ramnemark A, Andersson C et al. Prevalence of vitamin D deficiency and its association with nutrition, travelling and clothing habits in an immigrant population in Northern Sweden. European Journal of Clinical Nutrition (2016) 70, 373–37
11. Holick MF, Siris ES, Binkley N, et al. Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab 2005; 90:3215–24.
12. Binkley N, Krueger D, Cowgill CS et al. Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. J Clin Endocrinol Metab 2004; 89:3152–7.
13. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences- Am J Clin Nutr. 2008 Apr;87(4):1080S-6S
14. Pearce SH, Cheetham TD. Diagnosis and management of vitamin D deficiency. BMJ 2010; 340: b5664.
15. Rosen CJ, Gallagher JC. The 2011 IOM report on vitamin D and calcium requirements for North America: clinical implications for providers treating patients with low bone mineral density. J Clin Densitom 2011; 14: 79–84.
16. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 2011; 96: 53-58
17. Tang JCY, Nicholls H, Piec I, Washbourne CJ, Dutton JJ.et all. Reference intervals for serum 24,25-dihydroxyvitamin D and the ratio with 25-hydroxyvitamin D established using a newly developed LC–MS/MS method, Journal of Nutritional Biochemistry 46 (2017) 21–29.
18. Institute of Medicine 2011 Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press.
19. Çidem M, Karacan İ, Beytemur O et al. Prevalence and risk factors for vitamin D deficiency in patients with widespread musculoskeletal pain. Turk J Med Sci (2017) 47: 728-731/ doi:10.3906/sag-1508-30
20. Durmuş H, Çetinkaya F. Vitamin D Status of Adults in Kayseri, Turkey: Summer Time Population Based Cross-Sectional Study. J Clin Anal Med 2017;8(suppl 4): 325-9.
21. Hekimsoy Z, Dinç G, Kafesçiler S, Onur E, Güvenç Y, Pala T et al. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health 2010;10(1):782
22. Alagöl F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizlerli H et al. Sunlight exposure and vitamin D deficiency in Turkish women. Journal of Endocrinological Investigation 2000;23(3):173-7
23. Haq A, Svobodová J, Imran S, Stanford C, Razzaque MS. Vitamin D deficiency: A single centre analysis of patients from 136 countries. The Journal of steroid biochemistry and molecular biology 2016;164(9):209-13
24. Al-Hilali K. Prevalence of Hypovitaminosis D in Adult Iraqi People Including Postmenopausal Women. Scientific Research Journal (SCIRJ), Volume IV, Issue IX, September 2016, ISSN 2201-2796.
25. Hovsepian S, Amini M, Aminorroaya A, Amini P, Iraj B. Prevalence of Vitamin D Deficiency among Adult Population of Isfahan City, Iran. . J Health Popul Nutr (2011) Apr;29(2):149-155 ISSN 1606-0997.
26. Van der Wielen RP, Löwik MR, van den Berg H, de Groot LC, Haller J, Moreiras O, van Staveren WA: Serum vitamin D concentrations among elderly people in Europe. Lancet 1995, 346:207-2l0.
27. Lips P. Vitamin D status and nutrition in Europe and Asia. The Journal of Steroid Biochemistry and Molecular Biology 2007;103(3):620-5.