Serum pentraxin-3, vaspin, apelin ve troponinin dekompanze kalp yetersizliği hastalarındaki seviyeleri

Amaç: Vaspin, apelinve Pentraxin-3 (PTX-3),kardiyovasküler fonksiyonların, sıvı hemostazının, vasküler oluşumun, hücre proliferasyonunun, glukoz metabolizmasının ve inflamasyonun düzenlenmesinde etkili olduğu gösterilmiş biyomarkerlardır. Bu çalışmanın amacı, dekompanse kalp yetersizliği (KY) hastalarında bu biyobelirteçlerin düzeylerini değerlendirmektir.GereçveYöntemler: Çalışmaya 44 dekompanse KY hastası ve 32 sağlıklı birey, hasta ve control grubu olarak dahil edildi. Her iki grup için de transtorasik ekokardiyografi ve rutin laboratuvar analizlerinin yanında serum troponin I, vaspin, apelinve PTX-3 düzeyleri analiz edildi.Bulgular: Troponin I ve vaspin hasta grubunda daha yüksekti, apelin hasta grubunda daha düşüktü (hepsi için, p<0.05). PTX-3 düzeyleri hasta grubunda daha fazlaydı, ancak istatistiksel olarak anlamlı değildi (p=0.133). Troponin I ve PTX-3 düzeyleri hastaneiçi KY tedavisi ile anlamlı olarak azaldı (her ikisiiçin de, p<0.05). Vaspin ve apelin düzeyleri anlamlı bir değişiklik göstermedi (sırasıyla p=0.938, p=0.121). Vaspin troponin ile bağımsız bir ilişkiye sahipti, apelinin PTX-3 ile bağımsız bir ilişkisi vardı, troponin veapelin vaspin ile bağımsız bir ilişkisi vardı ve son olarak troponin, PTX-3 ve vaspin dekompanse KY hastalarında apelin ile bağımsız bir ilişkiye sahipti. Sonuç: Troponin I ve vaspin düzeyleri dekompanse KY hastalarında daha yüksekti serum apelin düzeyleri daha düşüktü. PTX-3 düzeyleri KY hastalarında daha yüksekti, ancak istatistiksel olarak anlamlı değildi. KY hastalarında vaspin ve apelin düzeyleri KY stabilizasyonu ile değişmedi, ancak troponin I ve PTX-3 düzeyleri anlamlı olarak azaldı.

Anahtar Kelimeler:

troponin I, vaspin, apelin, pentraxin-3, biobelirteç, dekompanse kalp yetersizliği

Serum levels of Pentraxin-3, Vaspin, Apelin and troponin in decompensated heart failure patients

Aim: The aim of the present study is to evaluate the levels of these biomarkers in decompensated heart failure (HF) patients.Material and Methods: 44 decompensated HF patients and 32 healthy individuals were enrolled in the study as patient and control groups. Transthoracic echocardiography and serum troponin I, vaspin, apelin, and PTX-3 levels besides routine laboratory analysis were performed for both groups.Results: Troponin I and vaspin were higher, apelin was lower in patient group (for all, p<0.05).PTX-3 levels were higher in patient group, but it was not statistically significant (p=0.133). Troponin I and PTX-3 levels were significantly decreased (for both, p<0.05) with in-hospital-HF treatment. Vaspinand apelin levels did not show any significant change (p=0.938, p=0.121, respectively). Vaspin had an independent relationship with troponin, apelin had an independent relationship with PTX-3, troponin and apelin had independent relationship with vaspin, and finally troponin,PTX-3, and vaspin had independent relationship with apelin in decompensated HF patients. Conclusion: Troponin I and vaspin levels were elevated,and serum apelin levels were reduced in decompensated HF patients. PTX-3 levels were higher in HF patients, but it was not statistically significant. Vaspin and apelin levels did not change with HF stabilization in HF patients, but troponin I and PTX-3 levels were significantly decreased.t

Keywords:

troponin I, vaspin, apelin, pentraxin-3, biomarker, decompensated heart failure,

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