Aydin Rodi TOSU, Tufan ÇINAR, Arda GULER, Serkan KAHRAMAN, İsmail GÜRBAK

Monosit/yüksek yoğunluklu lipoprotein oranının koroner arter ektaziyi öngörmedeki yararı

Amaç: Monosit sayısının yüksek yoğunluklu lipoprotein kolesterole oranı (MYYLKO) koroner arter hastalığı olan hastalarda yararlı bir enflamasyon belirteci olduğu gösterilmiştir. Bu nedenle, çalışmamızdaki amacımız MYYLKO’nın koroner arter ektazi (KAE) arasında ilişki olup olmadığını araştırmaktı.Gereç ve yöntemler: Geriye dönük vaka-kontrol çalışmasında, Temmuz 2013 ve Temmuz 2016 tarihleri arasında elektif koroner anjiyografi olan toplam 5500 hasta tarandı. Bu hastalardan, 150 (2,7%) hastada KAE bulundu. Kontrol grubu yaş, cinsiyet ve vücut kitle indeksi açısından eşleşen 150 normal koroner arter hastalarından oluştu. Bulgular: MYYLKO’nın ortanca değeri istatistiksel olarak KAE hastalarında daha yüksek bulundu (p<0.05).Çoklu değişken analizde, MYYLKO (Odds oranı:1.71, 95%Güven Aralığı:1.219-2.484, p=0.002) KAE’nin bağımsız öngörücüsü olarak saptandı. Sonuç: MYYLKO’nın KAE’li hastalarda sağlıklı kişilere göre daha yüksek olduğunu gözlemledik. Bu bulgularımız KAE ile koroner arter hastalığının ortak bir patofizyolojik mekanizmayı işaret edebilir.

Anahtar Kelimeler:

MYYLKO, enflamasyon, koroner arter ektazisi

The usefulness of monocyte to high density lipoprotein cholesterol ratio in prediction for coronary artery ectasia

Aim: Monocyte count to high density lipoprotein cholesterol ratio (MHR) has been shown to be a useful inflammatory marker in patients with coronary artery disease. Hence, the aim of the study was to evaluate whether there is an association between coronary artery ectasia (CAE) and MHR. Material and methods: In this retrospective case-control study, a total of 5500 patients who underwent an elective coronary angiography between July 2013 and July 2016 were retrospectively screened. Of these patients, 150 (2.7%) patients were found to have an isolated CAE. The control group was consisted of 150 normal coronary artery patients who matched with this group in terms of age, gender, and body mass index. Results: The median value of MHR was found to be a statistically higher in patients with CAE (p<0.05). In multivariable analyses, MHR (OR: 1.71, 95% CI: 1.219-2.484, p=0.002) was found to be an independent predictor of CAE. Conclusion: We observed that MHR levels were higher in CAE patients when compared to healthy subjects. Our findings may indicate a common pathophysiological mechanism between CAE and coronary artery disease.

Keywords:

MHR, inflammation, coronary artery ectasy,

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