Sami BENLİ, Süleyman Özkan AKSOY, Ali İbrahim SEVİNÇ, Serdar SAYDAM, Merih Güray DURAK

Lokal ileri meme kanserinde metastatik lenf nodu oranının prognostik değeri

Öz Amaç: Bu çalışmada, lenf nodu oranının prognostik önemini değerlendirdik (LNR: metastatik lenf nodlarının toplam disseke edilen lenf nodlarına oranı). Gereç ve Yöntemler: Bu retrospektif çalışmada meme kanseri nedeniyle koltuk altı diseksiyonu yapılan hastalar incelendi. 2006-2016 yılları arasında 9 Eylül Üniversitesi Hastanesi'nde metastatik olmayan meme kanseri nedeniyle koltuk altı diseksiyonu yapılan 348 kadını değerlendirdik. LNR düşük, orta ve yüksek riskli (düşük, ≤0.20; orta, 0.21-0.65; yüksek> 0.65) olarak üç gruba ayrıldı. Hastaların genel sağkalımı, LNR için Kaplan Meier yöntemi ile tahmin edildi. LNR ve pN ile ilişkili genel bağıl ölüm riskleri Cox regresyonu ile hesaplandı. Bulgular: Ortalama talip süresi 76.73 ay olarak bulundu. Ortalama sağkalım LNR yüksek riskli grupta 95.1 ay iken, N3 grubunda 100 aydı. İstatistiksel olarak anlamlı olmamakla birlikte, LNR yüksek grupta 5 aydan daha düşük sağkalım oranı gözlendi (P 0.65 HR 3.08; p = 0.002). Sonuç: LNR meme kanserinde oldukça önemlidir ve prognoz açısından TNM'den çok daha değerli bilgiler sağlar. Bu nedenle LNR'nin meme kanseri evrelemesinde faydalı bir araç olarak kullanılabileceğini düşünüyoruz.

Anahtar Kelimeler:

meme kanseri, lenf nodu oranı, survi

Prognostic value of metastatic lymph node ratio in locally advanced breast cancer

Aim: In this study we evaluated the prognostic value of the lymph node ratio. (LNR: defined as the number of involved nodes divided by the number of the nodes examined). Patients and Methods: In this retrospective study, patients underwent axillary dissection due to breast cancer were examined. We evaluated 348 women underwent axillary dissection for nonmetastatic breast cancer in 9 Eylül University Hospital between 2006 and 2016. LNR were divided into three groups as low, intermediate and high risk (low, ≤0.20; intermediate, 0.21-0.65; high, > 0.65). Overall survival of the patients was estimated by the Kaplan Meier method for LNR. Overall relative mortality risks associated with LNR and pN were calculated by Cox regression. Results: The mean survival was 95.1 months LNR high-risk group, while it was 100 months in N3 group. Even though it was not statistically significant, a lower survival rate of less than 5 months was observed in the LNR high group (P 0.65 HR 3.08; p=0.002). Conclusion: LNR is highly significant in breast cancer and it provides more valuable information rather than TNM in terms of prognosis. Therefore, we think that, LNR can be used as a beneficial tool in breast cancer staging.

Keywords:

breast cancer, lymph node ratio, survival,

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