Koroner yavaş akımın ortalama trombosit nacmi/lenfosit oranı ile İlişkisi

Amaç: Bu çalışmanın amacı, kolayca hesaplanabilen yeni bir inflamatuar belirteç olan ortalama trombosit hacmi/ lenfosit oranının koroner yavaş akım şiddeti ile ilişkisini araştırmaktır.Gereç ve Yöntemler: Kesitsel tipte yapılan bu çalışmada, Nisan 2016 ile Nisan 2017 tarihleri arasında hastanemize başvuran toplam 166 hasta dahil edilmiştir. Koroner yavaş akım grubuna 83 hasta, normal koroner akım grubuna 83 hasta dahil edildi. Tüm hastaların koroner akım hızları Timi Kare Sayımı (TIMI) yöntemi ile hesaplanmıştır. Tüm verilerin analizi için SPSS 22.0 istatistiksel paket programı kullanılmıştır.Bulgular: Ortalama trombosit hacmi/ lenfosit oranı, koroner yavaş akım grubunda normal koroner akım grubuna göre istatistiksel olarak daha anlamlı bulundu. (p <0.001) Çok değişkenli lojistik regresyon analizinde, ortalama trombosit hacmi/ lenfosit oranı koroner yavaş akımın bağımsız öngördürücüsü olduğu bulundu. (p <0.001) Buna ek olarak, HsCRP, total kolesterol, HDL ile koroner yavaş akım arasında pozitif bir korelasyon saptandı. (p <0.05) Sonuç: Yeni ve basit bir inflamasyon göstergesi olan ortalama trombosit hacmi / lenfosit oranı, koroner yavaş akım saptanan hastalarda daha yüksek bulundu. Bu yüksek oran, koroner yavaş akım saptanan hastaları takipte klinisyenler için önemli bir gösterge niteliği taşıyor olabilir.

Anahtar Kelimeler:

inflamasyon, lenfosit, ortalama trombosit hacmi, yavaş akım

Relationship between coronary slow flow and mean platelet volume / lymphocyte ratio

Aim: The aim of this study was to investigate the association of the mean platelet volume to lymphocyte ratio, a novel inflammatory marker that is easily calculated, with coronary slow flow severity.Material and Method: In this cross-sectional study, a total of 166 patients referred to our hospital between April 2016 and April 2017 were included. 83 patients were included in the coronary slow flow group, and 83 patients were included in the normal coronary flow group. Coronary flow velocities of all patients were measured by the Timi Frame Count (TIMI) method. SPSS 22.0 statistical package program was used for analysis of all data.Results: MPVLR was statistically more significant in coronary slow flow group compared to normal coronary flow group.(p<0.001) In multivariate regression analysis, MVPLR was found to be an independent predictor of coronary slow flow.(p<0.001) In addition, there was a positive correlation between HsCRP, total cholesterol, HDL and coronary slow flow. (p<0.05) Conclusion: Mean platelet volume to lymphocyte ratio, a new and simple indicator of inflammation, was found to be higher in patients with coronary slow flow. This high ratio may be indicative for clinicians following patients with severe coronary slow flow.

Keywords:

inflammation, lymphocyte, mean platelet volume, coronary slow fl,

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