Hodgkin ve Non-Hodgkin Lenfoma tanılı hastalarda nötrofil/lenfosit oranı, trombosit/lenfosit oranı, trombosit/nötrofil oranı ve ortalama trombosit hacminin prognostik önemi

Amaç: Kolay ulaşılabilir NLR, PLR, PNR ve MPV değerlerinin lenfoma alt tiplerinde prognostik belirteç olarak kullanılıp kullanılamayacağını ve mevcut prognostik skorlama sistemlerine ek katkı sağlayıp sağlayamayacağını göstermeyi amaçladık. Gereç ve Yöntemler: 2005-2019 tarihleri arasında ki tüm lenfoma hastalarının kayıtları retrospektif olarak incelenmiştir. Tanı anında ki NLR, PLR, PNR ve MPV değerleri ile PFS ve OS süreleri karşılaştırılmıştır. Bulgular: Marjinal zone lenfomada PLR ve NLR değerleri ve DBBHL’da da PNR ve MPV değerlerinin prognoz ile ilişkili olduğu, PFS ve OS üzerine doğrudan etkisi olduğu saptandı. Bu parametreler dışında tüm hasta grubu için LDH, MPV, yaş, evre ve histolojik alt tipin prognoz üzerinde etkili olduğunu saptadık. Sonuçlar: Sonuç olarak PLR ve NLR Marjinal Zone lenfomada, PNR ve MPV’de DBBHL da prognostik faktör olarak kullanabilir. Hastalık prognoz skorlarında kolay ulaşılabilir yöntemler olarak yerlerini alabilirler.

Anahtar Kelimeler:

lenfoma, prognoz skoru, pnr, mpv, pfs, os

Prognostic significance of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, platelet/neutrophil ratio, and mean platelet volume in patients diagnosed with Hodgkin and Non-Hodgkin Lymphoma

Aim: We aimed to show whether easily accessible NLR, PLR, PNR and MPV values can be used as prognostic markers in lymphoma subtypes and whether they can contribute to existing prognostic scoring systems. Material and Methods: The records of all lymphoma patients between 2005-2019 were reviewed retrospectively. NLR, PLR, PNR and MPV values at the time of diagnosis were compared with Progression-Free Survival (PFS) and Overall Survival (OS) durations. Results: PLR and NLR values in Marginal Zone Lymphoma (MZL) and PNR and MPV values in Diffuse Large B-cell Lymphoma (DLBCL) were found to be associated with prognosis and to have a direct effect on PFS and OS. Except for these parameters, we found that lactate dehydrogenase (LDH), MPV, age, stage and histological subtype had an effect on prognosis for all patients. Conclusion: It has been concluded that PLR and NLR can be used as prognostic factors in MZL, whereas PNR and MPV can be used as prognostic factors in DLBCL, and that these values can be used as easily accessible methods in disease prognosis scores.

Keywords:

Lymphoma, prognostic score, pnr, mpv, pfs, os,

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