Hipertansiyon tanısı alan hastalarda angiotensinojen (AGT) gen taraması ve nutrigenetik yaklaşımlar

Aim: Today, hypertension is one of the most important preventable risk factors for diseases with fatal consequences such as stroke, heart failure, myocardial infarction, peripheral vascular disease, and end-stage renal failure, and it is estimated that there are approximately 15-16 million hypertension patients in Turkey. The aim of the study; to determine the nutritional habits of patients with clinically diagnosed hypertension and to investigate the nutrigenetic approaches of the disease. Method:For this purpose, the study is planned as two-stage. In the first stage, it was aimed to examine the nutritional habits by applying a questionnaire to the patients diagnosed with hypertension. In the second stage, it was aimed to reveal genetic changes by a screening of the Angiotensinogen gene which is the disease-related gene in the clinically diagnosed patients.. Results: In the result of the study; p.M268T change in Angiotensinogen gene was defined in one patient and this change was defined in the literature as rs699 /NCBI, which is known as one of the most important polymorphisms associated with hypertension. In addition, it was found that there was no change in nutritional patterns before and after diagnosis of hypertensive individuals and the rates of interviewing with dietitians were very low. Conclusion: The study is important as it is the first study conducted in terms of nutrigenetics in patients diagnosed with hypertension in the Turkish population.

Anahtar Kelimeler:

Hipertansiyon, Nutrigenetik, Angiotensinojen geni

Angiotensinogen (AGT) gene screening and nutrigenetic approaches in patients diagnosed with hypertension

ABSTRACT Aim: Today, hypertension is one of the most important preventable risk factors for diseases with fatal consequences such as stroke, heart failure, myocardial infarction, peripheral vascular disease, and end-stage renal failure, and it is estimated that there are approximately 15-16 million hypertension patients in Turkey. The aim of the study; to determine the nutritional habits of patients with clinically diagnosed hypertension and to investigate the nutrigenetic approaches of the disease. Method:For this purpose, the study is planned as two-stage. In the first stage, it was aimed to examine the nutritional habits by applying a questionnaire to the patients diagnosed with hypertension. In the second stage, it was aimed to reveal genetic changes by a screening of the Angiotensinogen gene which is the disease-related gene in the clinically diagnosed patients.. Results: In the result of the study; p.M268T change in Angiotensinogen gene was defined in one patient and this change was defined in the literature as rs699 /NCBI, which is known as one of the most important polymorphisms associated with hypertension. In addition, it was found that there was no change in nutritional patterns before and after diagnosis of hypertensive individuals and the rates of interviewing with dietitians were very low. Conclusion: The study is important as it is the first study conducted in terms of nutrigenetics in patients diagnosed with hypertension in the Turkish population.

Keywords:

Hypertension ; Nutrigenetic ; Angiotensinogen gene, Hypertension; Nutrigenetic; Angiotensinogen gene, Angiotensinogen gene,

PDF

___

Referans1. Alphan ME. Nutrition Therapy in Hypertension. Hatiboğlu Yayıncılık. Ankara. 2013; 367-384.
Referans2. Babalık E. The Pathophysiology of Hypertension. Klinik Gelişim. 2005; 18(2): 25-32.
Referans3. The European Society of Cardiology, The European Respiratory Society. Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension. European Heart Journal. 2016; 37: 67-119.
Referans4. The European Society of Cardiology, The European Respiratory Society. Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension. European Heart Journal. 2009; 30: 2493-2537.
Referans5. Parthvi R, Sikachi R.R, Agrawal A, Adial A, Vulisha A, Khanijo S, Talwar A. Pulmonary Hypertension Associated with Antiphospholipid Antibody: Call for a Screening Tool? . Intractable & Rare Diseases Research. 2017; 6(3): 163-171.
Referans6. Onat A, Can G, Yüksel H, Ademoğlu E, Erginal N, Kaya A, Altay S. TEKHARF 2017 – Leading the Approach of the Medical World to Chronic Diseases. Ed: Onat A. Logos Yayıncılık. İstanbul. 2017.
Referans7. Arıcı M, et al. Turkish Hypertension Consensus Report. Turk Kardiyol Dern Ars. 2015; 43(4): 402-409.
Referans8. Kaya A. Obesity and Hypertension. Turkish Journal of Endocrinology and Metabolism. 2003; 2: 13-21.
Referans9. Alphan M.E. DASH (Hypertension) Diet. Ed: Alphan M.E Diyetler & Gerçekler. Hatiboğlu Yayınları. Ankara. 2016; 135-148.
Referans10. Budak M. Investigation of ACE Gene Polymorphism in Patients with Hypertension. Trakya University Biophysics Department Master Thesis. 2006.
Referans11. Public Health Agency of Turkey. Excessive Salt Consumption Reduction Program of Turkey 2017-2021. Ankara. 2016.
Referans12. Reid I.R. Cardiovascular Effects of Calcium Supplements. Nutrients. 2013; 5: 2522-2529.
Referans13. Houston M.C, Harper K.J. Potassium, Magnesium and Calcium: Their Role in Both the Cause and Treatment of Hypertension. The Journal of Clinical Hypertension. 2008; 10(7): 3-11.
Referans14. Durmaz C, Arslan P. Hypertension and Factors Affecting Blood Pressure in the Community. Beslenme ve Diyet Dergisi. 2017; 45(3): 278-286.
Referans15. Seçer S, Özden A, Güllüoğlu Ş, Ekinci F.Y. Personalized Nutrition Based on Genotyping for Prevention of Diet-Related Diseases and Improving Quality of Life. Akademik Gıda. 2011; 9(4): 51-59.
Referans16. Dickson ME, Sigmund CD. Genetic Basis of Hypertension Revisiting Angiotensinogen. Hypertension. 2006; 48: 14-20.