Protein C İnhibitörü/SERPİNA5 analizi

Protein C inhibitörü (PCI), serin proteaz ailesinden (SERPINA5) α1 proteaz inhibitiör prototipinde bir plazma glikoproteinidir. İlk olarak insan plazmasında aktive protein C inhibitörü olarak daha sonra ise koagülasyon ve fibrinolizisin inhibitörü olarak tanımlanmıştır. PCI, idrardan sekrete olur ve ürokinaz tipi plazminojen aktivatörü (uPA) ile kompleks oluşturur. Bu nedenle plazminojen aktivatör inhibitörü 3 (PAI-3) olarak da bilinir. PCI’nın tromboz ve fibrinoliziste, fertilizasyonun düzenlenmesinde, doku rejenerasyonunda, vasküler permeabilitede, tümör gelişimi, invazyon, metastaz ve anjiyogenezin düzenlenmesinde rol oynadığı bilinmektedir Bu derlemede; PCI'ın işlevleri hakkında bilgi vermek ve ileride yapılacak çalışmalar için rehberlik sağlamak amaçlanmıştır.

Anahtar Kelimeler:

Protein C, SERPINA5

Analysis of Protein C Inhibitor/ SERPINA5

Protein C inhibitor is a non-specific serine protease inhibitor with extensive protease reactivity. Protein C inhibitor (SERPINA5, plasminogen activator inhibitor-3/PAI-3) is a secreted, extracellular clade A serpin. SERPINA5/PCI has originally been described as an inhibitor of activated protein C and independently as an inhibitor of the plasminogen activator urokinase. SERPINA5 binds glycosaminoglycans, phospholipids, and retinoic acid. Glycosaminoglycans and certain phospholipids can modulate its inhibitory activity and specificity. PCI plays role at thrombosis and fibrinolysis, regulation of fertilization, tissue regeneration, vascular permeability, tumor development, invasion, metastasis and angiogenesis. In this review; aimed to provide information about the functions of PCI and to provide guidance for studies.

Keywords:

Protein C Inhibitor, SERPINA5,

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