Alopesi areata ile serum 25 (OH) D vitamini ilişkisi

Amaç: Alopesi areata (AA) hastalarında serum 25-hidroksivitamin D (25 (OH) D) seviyelerini incelemek ve sağlıklı bireylerden oluşan kontrol grubu ile karşılaştırarak serum 25 (OH) D seviyeleri ile AA arasında olası bir ilişki olup olmadığı belirlemektir. Gereç ve Yöntemler: Ekim 2017-Mart 2018 tarihleri arasında AA tanısı konulan 43 hasta ve 69 sağlıklı birey çalışmaya alındı.Çalışma grubunun serum D vitamini düzeyleri yüksek performans likit kromatografi yöntemi ile değerlendirildi. Ayrıca serum kalsiyum, fosfor, alkalen fosfataz ve paratiroid hormon seviyeleri de değerlendirildi. Bulgular: Çalışmamıza 10-47 yaş(ortalama: 33.41 ± 7.2) arasındaki 43 hasta ve kontrol grubunda 18-55 yaş arası(ortalama: 33,53 ± 7.2). 69 sağlıklı birey katılmıştır. AA'lı hastalarda serum 25 (OH) D seviyeleri ortalama 20,21 ng / ml (3,7-43,5 ng / ml) olarak belirlendi. Kontrol grubunda ise serum 25 (OH) D seviyeleri ortalama 24,09 ng /ml(3-69,2 ng / ml) olarak belirlendi.. Her iki grup arasında serum D vitamini düzeyi arasında istatistiksel olarak anlamlı bir fark yoktu(p> 0.05). Sonuç: Bu sonuçlar ışığında AA ile serum 25(OH) D vitamini arasında herhangi bir ilişki saptanmamıştır.

Association between 25 (OH) vitamin D and alopecia areata

Aim: To evaluate the status of serum 25-hydroxyvitamin D(25(OH)D) in patients with AA,serum 25(OH) D concentrations were compared with AA patients and healthy controls and thus determine if a possible association exists between serum 25(OH) D levels and AA. Materials and Methods: The study comprising 43 patients diagnosed with AA and 69 healthy controls was conducted between October 2017 and March 2018.The serum vitamin D levels of the study group were determined by high performance liquid chromatography.Serum levels of calcium,phosphorus,alkaline phosphatase, and parathyroid hormone were also evaluated. Results: The study was based on 43 patients aged between 10 and 47 (mean:33,41±7,2).The control group included 69 healthy persons aged between 18 and 55 (mean:33,53±7,2).Serum 25(OH)D levels in patients with AA ranged from 3,7 to 43,5 ng/ml with a mean of 20,21 ng/ml. Serum 25(OH)D levels in healthy controls ranged from 3 to 69,2 ng/ml with a mean of 24,09 ng/ ml.There was no statistically difference in the serum vitamin D level between AA patients and healthy controls(p> 0.05) Conclusion: In the light of these results, no relationship was found between AA and serum 25 (OH) vitamin D.

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